... enzyme inhibition (compare 12 against 13 and 15 in Fig. 1). Following thepreliminary screen, each of the four most promisinginhibitors was used in further inhibition analysisto determine their ... anchored in the brush border epithelialcells of the small intestine. MGA contains five distinctprotein domains: a small cytosolic domain (26 aminoacids) a transmembrane domain (20 amino acids), ... In order to examine the mechanism of action of thisclass of inhibitors, 3, 5, the stereoisomers of salacinol6, 7 [25], and the six-membered ring analogues of salacinol (8, 9) (N. S. Kumar and...