Báo cáo hóa học: " Epitope characterization of the protective monoclonal antibody VN04-2 shows broadly neutralizing activity against highly pathogenic H5N1" ppt

... Central Page 1 of 4 (page number not for citation purposes) Virology Journal Open Access Short report Epitope characterization of the protective monoclonal antibody VN04-2 shows broadly neutralizing activity ... determine the actual effects mutations in this region of the HA gene has on antibody binding and the utility of the antibody for pro- tection...

Ngày tải lên: 20/06/2014, 01:20

... standards. The ratios of the experime ntal intensity of subla yers 1 and 2 to the intensity of all the inner standards are then com- pared to the calculated values of similar ratios for all the all ... properly cited. The alloy whose R matches the experimental ratio R exp is the one that a sublayer is made of. The experimental ratios R exp of the HAADF intensi...

Ngày tải lên: 21/06/2014, 05:20

... between the two steps of the TES reaction The substrate guanosine to be excised (G 1 ) and its 2¢-OH group are required for the second step of TES [48], similar to (if not the same as) the role of the ... that there is room for improve- ment in terms of the rate of reaction. This would be beneficial not so much in terms of the rate of the over- all reaction, a...

Ngày tải lên: 18/02/2014, 18:20

... different flavonoids. The addition of a flavone (apigenin), of a flavanonol (taxifolin) and of a flavan-3-ol (epicatechin) (Fig. 8) did not alter the EPR spectra of the enzyme indicating the absence of binding to the ... definition of some of the catalytic steps. Binding of the various flavonols to the active site metal centre is found not to require the presence...

Ngày tải lên: 22/02/2014, 07:20

... binding. The signal of the C-methyl group of the same N-acetimidoyl groups was observed as was the signal of the C-methyl group of the N-acetyl group linked to C7 in the side chain of the respective ... a-andb-con®guration in a ratio of approximately 5 : 1, which is also the case for free Rha II in the other 30% of the molecules. The anomeric con®guration...

Ngày tải lên: 08/03/2014, 10:20

... properties of SPC4. The absorption spectrum of purified SPC4 was recorded in 50 m M sodium acetate pH 5. The inset shows the spectrum of the extract- ed heme. (B) MALDI-TOF-MS analysis of SPC4 heme. Characterization ... (T m ¼ 74 °C) [37]. In the presence of Ca 2+ , the T m of SPC4 is near that of soybean peroxidase, which is one of the most stable plant perox...

Ngày tải lên: 16/03/2014, 13:20

... amplitude of the fast phase of the l atter represen ted up to 40% of the total amplitude, with a rate constant (k obs ) independent of Pc concentration (data not shown). From the k obs values of this fast ... interactions with both PSI and Cyt f, but the solvent-exposed edge of His87, located in the hydrophobic patch at the so-called Ônorthern sideÕ of the protei...

Ngày tải lên: 16/03/2014, 16:20

... undetectable in five of the 10 selected structures. Figure 8E shows a represen- tation of the e lectrostatic potential associated with the contact s urface of the N ogo-40 structure. The m ost interesting ... Zn 2+ . Furthermore, the d etermination of the Nogo-40 solution structure offers a starting point for further understanding the interaction between NgR and Nogo-...

Ngày tải lên: 16/03/2014, 16:20

... cm )1 ) of the Fe(II)–CO complex of isolated PAS-B in the low (left) and high (right) fre- quency regions. The lower spectra are of the Fe(II)– 12 C 16 O complexes, the middle spectra are of the ... different from the wild-type. For example, the spectrum of the Fe(III) His302Ala mutant (data not shown) was essentially the same as that of the Fe(III) wild-type...

Ngày tải lên: 16/03/2014, 22:20

... of note that the structure of the LPS O-antigen of F. columnare differs structurally from the LPS O-antigen of the fish pathogen Flavobacterium psychrophilium [21], which is a linear polymer of ... However, the nature of the adhesins involved have not been identified, but possible candidates are LPS, capsule, fimbriae or other appendages of the bacterium, a hypothesis...

Ngày tải lên: 17/03/2014, 10:20