... efficacy and possiblemechanism(s) of action of a conjugate of Andro and LA,i.e., andrographolide-lipoic acid conjugate (AL-1, Fig. 1), in vitro and in experimental diabetic animal models.MethodsReagentsAL-1 ... and 100 μg/ml of streptomycin.Structures of Andro, LA and AL-1Figure 1Structures of Andro, LA and AL-1.Journal of Translational Medicine 2009, 7:62 http://www.translational-medicine.com/content/7/1/62Page ... 2006,55:2238-2 244 .16. Jiang X, Yu P, Jiang J, Zhang Z, Wang Z, Yang Z, Tian Z, Wright SC,Larrick JW, Wang Y: Synthesis and evaluation of antibacterialactivities of andrographolide analogues. Eur...