báo cáo hóa học: " Induction of serine racemase expression and D-serine release from microglia by amyloid β-peptide" pdf

Tài liệu Báo cáo khoa học: Induction of uPA gene expression by the blockage of E-cadherin via Src- and Shc-dependent Erk signaling docx

Tài liệu Báo cáo khoa học: Induction of uPA gene expression by the blockage of E-cadherin via Src- and Shc-dependent Erk signaling docx

... addi- tion to the loss of cell–cell adhesion, involves degrada- tion of the extracellular matrix and release of cells from the constraints of cell–cell and cell–matrix interaction. MMPs and urokinase-type ... increased expression of uPA is directly related to higher tumor growth and metastasis [1]. Several analyses have already made it clear that the expression of...
Ngày tải lên : 19/02/2014, 05:20
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Báo cáo khoa học: Induction of PAI-1 expression by tumor necrosis factor a in endothelial cells is mediated by its responsive element located in the 4G/5G site ppt

Báo cáo khoa học: Induction of PAI-1 expression by tumor necrosis factor a in endothelial cells is mediated by its responsive element located in the 4G/5G site ppt

... inhibition of NF-jB, either by antisense oligonucleotide or by overexpression of IjBa, attenu- ated both TNFa- and H 2 O 2 -induced PAI-1 expression. TNFa was reported to induce both superoxide anion and ... Dependence of PAI-1 expression upon NF-jB activation. (A, B) Inhibition of PAI-1 antigen expression produced by incu- bation of TNFa-stimulated endothelial cells...
Ngày tải lên : 30/03/2014, 11:20
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Báo cáo hóa học: " Correlation of pharmacodynamic activity, pharmacokinetics, and anti-product antibody responses to anti-IL-21R antibody therapeutics following IV administration to cynomolgus monkeys'''' pot

Báo cáo hóa học: " Correlation of pharmacodynamic activity, pharmacokinetics, and anti-product antibody responses to anti-IL-21R antibody therapeutics following IV administration to cynomolgus monkeys'''' pot

... gene expression was quantified using relative quantification (RQ) units, as described in Materials and Methods. Not all animals had induction of gene expression of all of the above genes and there ... PD study of Ab-01 and Ab-02 in cynomolgus mon- keys (RQ cutoff ) was defined as 2.3 using the formula: log [RQ cutoff ] = mean of the log-transformed RQ values - standard d...
Ngày tải lên : 18/06/2014, 16:20
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Báo cáo hóa học: " Overexpression of microRNA-206 in the skeletal muscle from myotonic dystrophy type 1 patients" docx

Báo cáo hóa học: " Overexpression of microRNA-206 in the skeletal muscle from myotonic dystrophy type 1 patients" docx

... quantification of Utrophin and Tubulin (used as housekeeping protein) in Figure 1 QRT-PCR quantification of myo-miRs and miR-133 and miR-107 in biopsies from vastus lateralis of 7 DM1 patients ... repressor factors of the wild type and mutant DMPK transcripts. The binding of miR-103 and miR-107 to the 3'UTR of the DMPK expanded mRNAs could therefore affects the s...
Ngày tải lên : 18/06/2014, 16:20
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Báo cáo hóa học: "Quantification of newly produced B and T lymphocytes in untreated chronic lymphocytic leukemia patients" ppt

Báo cáo hóa học: "Quantification of newly produced B and T lymphocytes in untreated chronic lymphocytic leukemia patients" ppt

... confounding effect of tumor DNA derived from monoclonal B cells on the quantifi- cation of KRECs and TRECs, genomic DNA from PBMC of 2 healthy donors with high and low number of KRECs and TRECs was ... KRECs are randomly present in about 5 0% of B cells released from the bone marrow and TRECs in 70% of T cells leaving the thy- mus, their quantification is considered...
Ngày tải lên : 18/06/2014, 16:20
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Báo cáo hóa học: " Comparison of the self-administered and interviewer-administered modes of the child-OIDP" ppt

Báo cáo hóa học: " Comparison of the self-administered and interviewer-administered modes of the child-OIDP" ppt

... Child-OIDP and some of the asso- ciations between the Child-OIDP and proxy measures were not significant. While the low value of alpha is affected by the nature of the Child-OIDP index and the fact ... interview time and respondent burden, the use of pictures have been used in the Thai version of Child-OIDP [1,21] while a shorter version of the OIDP based only on the ass...
Ngày tải lên : 18/06/2014, 22:20
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Báo cáo khoa học: Characterization of L-aspartate oxidase and quinolinate synthase from Bacillus subtilis potx

Báo cáo khoa học: Characterization of L-aspartate oxidase and quinolinate synthase from Bacillus subtilis potx

... the enzyme from E. coli [9], NadB from B. subtilis is a dimer of 115 kDa in the absence of NaCl and a mono- mer of 55 kDa in the presence of 150 mm NaCl. After incubation with pure NadA in ratios of ... horikoshii and Sulfol- obus tokadaii, and characterized from a biochemical and structural point of view only from E. coli and S. tokadaii [8–17]. It is a flavoprot...
Ngày tải lên : 30/03/2014, 02:20
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Báo cáo khoa học: Inhibition of Hsp90 function delays and impairs recovery from heat shock ppt

Báo cáo khoa học: Inhibition of Hsp90 function delays and impairs recovery from heat shock ppt

... FEBS Inhibition of Hsp90 function delays and impairs recovery from heat shock Roger F Duncan 1,2 1 Department of Molecular Pharmacology and Toxicology, University of Southern California School of Pharmacy, ... accumulation of a threshold level of Hsp70 sig- nals the cessation of Hsp mRNA transcription and the restoration of the normal rate of protein synthesis. This...
Ngày tải lên : 30/03/2014, 20:20
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Tài liệu Báo cáo khoa học: ¨ Induction of Kruppel-like factor 4 by high-density lipoproteins promotes the expression of scavenger receptor class B type I pptx

Tài liệu Báo cáo khoa học: ¨ Induction of Kruppel-like factor 4 by high-density lipoproteins promotes the expression of scavenger receptor class B type I pptx

... differentiation and proliferation of VSMCs. Overexpression of KLF4 induced expression of multiple anti-inflammatory and antithrombotic factors, whereas knockdown of KLF4 led to the enhancement of tumour ... addition, the effects of KLF4 on the expression of SR-BI and the primary mechanism were also investigated. Results HDL induces the expression of KLF4 and SR-BI...
Ngày tải lên : 18/02/2014, 04:20
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Tài liệu Báo cáo Y học: Induction of (2¢)5¢)oligoadenylate synthetase in the marine sponges Suberites domuncula and Geodia cydonium by the bacterial endotoxin lipopolysaccharide docx

Tài liệu Báo cáo Y học: Induction of (2¢)5¢)oligoadenylate synthetase in the marine sponges Suberites domuncula and Geodia cydonium by the bacterial endotoxin lipopolysaccharide docx

... very likely by inhibition of cell proliferation or induction of apoptosis. MATERIALS AND METHODS Materials Restriction endonucleases and other enzymes for recombin- ant DNA techniques and vectors ... The i dentity of the p 3 A 2 product synthesized by the (2–5)A synthetase both in tissue and in primmorphs of S. domuncula was verified by TLC and HPLC analysis as tripho...
Ngày tải lên : 21/02/2014, 15:20
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