... theirmain roles focus on ectodomain shedding and nonpro-teolytic functions, such as binding to adhesion mole-cules, integrins and interacting with phosphorylationsites for serine ⁄ threonine and ... one-third of all solid tumors[20]. During cancer progression, increased shedding of the membrane-anchored ligands of EGFR, includingheparin-binding EGF (HB-EGF), transforming growthfactor (TGF)-a and ... tetracyclines, lacking antibiotic activities, mayinhibit MMPs by binding to metal ions such as zinc and calcium. This family of inhibitors, including metastat(COL-3), minocycline and doxycycline, cause...