Báo cáo sinh học: " Adeno-associated virus: from defective virus to effective vector" potx

... along the rostral migratory stream (RMS) from the SVZ into the olfactory bulb, where they differentiate into two kinds of inhibitory neurons [57]. Given that len- tiviral vectors pseudotyped with ... NS048866-01 (to D.B. McGavern), AI070967-01 (to D.B. McGavern), and MH062261-06 (pilot grant to D.B. McGavern), a grant from The Dana Foundation (to D.B. McGavern), and a grant from...

Ngày tải lên: 18/06/2014, 18:20

... the mitochon- drial matrix observed previously in NiV infected cells [12]. This can lead to the rupture of the mitochondrial outer membrane and release of the mitochondrial proapoptotic factors ... factors then induce apoptosis to the neuronal cell cultures seen in the present study. Increased abundance of cytochrome bc1, a component of the ubiq- uinol-cytochrome c reductase complex (cyto...

Ngày tải lên: 18/06/2014, 18:20

... response to platinum-based regimens in patients with peritoneal carcinomatosis from ovarian cancer. Among the markers studied, MGMT and XPD gene expression proved effective in predicting response to platinum-contai ... response to platinum or platinum based regimens, in a series of patients with peritoneal carcinomatosis from ovarian cancer. Patients and Methods Patients Thirty-tw...

Ngày tải lên: 18/06/2014, 19:20

... DNA sequence from 250 bp upstream of the I7L ORF, to include the native promoter, and to aid in homologous recombination. This plasmid was used to create the recombinant virus vtetOI7L using the ... operator did not have an effect on the growth kinetics of the inducible mutant virus. To demonstrate that the replication defect of the vtetOI7L mutant virus in the absence of TET w...

Ngày tải lên: 18/06/2014, 22:20

... co-receptor in addition to CD4 for entry into cells. Primary HIV can use a broad range of co-receptor molecules, including CCR1, CCR2b, CCR3, CCR4 and CXCR4 [1-3]. However, expression of a co-receptor together ... con- centration of IM28 did not lead to the burst (Figure 4). To further characterize the biological effect of the drug, the 50% inhibitory dose (IC50) and the cytotoxic dose...

Ngày tải lên: 18/06/2014, 22:20

... respectively. Viruses were engulfed by phagocytosis and macropicnocytosis leading to huge vacuoles and phagosomes inside the monocytes. Interaction of monocytes with DEN2 virus induced apoptosis, characterized ... infection by mosquito vector. Background Monocyte/macrophages are one of the major target of dengue virus and responsible for virus dissemination after its initial entry via...

Ngày tải lên: 19/06/2014, 08:20

... component to exert their inhibi- tory effects cannot be ruled out. However, the majority of flavivirus neutralizing antibodies that appear to be involved in receptor blocking bind to domain III, ... 693–723 a DENV: dengue virus; WNV: West Nile virus; YFV: yellow fever virus; SLEV: St. Louis encephalitis virus; JEV: Japanese encephalitis virus; TBEV: Tick- borne encephalitis virus;...

Ngày tải lên: 19/06/2014, 08:20

... has been observed in plant viruses, and has been recently reported with several mammalian viruses including LaCrosse virus, adenovirus, and influenza A virus [32- 34,40-43]. To determine if WNV replication ... [14,15,17-20]. Many mammalian viruses appear susceptible to treatment with exogenous siRNA. Cells that express virus- specific siRNA are resistant to infection by WNV [21], po...

Ngày tải lên: 19/06/2014, 08:20

... transmits several of these viruses, resulting in greatly elevated inci- dence of these viruses [1,3,10]. Of these, deformed wing virus (DWV) appears to be closely associated with Varroa destructor infestation ... nucleotide probes hybridizing to the 3' portion of the DWV genome were used to identify DWV RNA, while a monospecific antibody to the DWV-VP1 structural protein was us...

Ngày tải lên: 19/06/2014, 08:20

... propose that, even with adequate funding, efforts to implement HR plans and obtain results may fail due to other factors. Factors that contribute to the failed implementation of human resource ... the private sector all have a role to play. Progress in dealing with these factors depends on manag- ers who are able to lead and inspire teams at all levels of the health system to tra...

Ngày tải lên: 18/06/2014, 17:20