... and consisted of a linker (Glc-Kdo 2 )-lipid A structure. The phenotype of this mutant was examined to investigate the roles of different moieties of the LOS molecule in biological activities of the ... mutant was similar to the wild-type strain in its growth rate, toxicity and susceptibility to hydrophobic reagents. However, the mutant was sensi- tive to bactericidal ac...
Ngày tải lên: 07/03/2014, 05:20
... UDP-glucosyltransferase gene, Bmugt1,and analysis of the activity of the enzyme towards a range of Correspondence to D. R. O’Reilly, Department of Biology, Imperial College of S cience, Technology and Med icine, ... as toxins or feeding deterrents to i nsects and thus play an important role in plant d efence against herbivorous insects. The detoxication of ingested plant pheno...
Ngày tải lên: 22/02/2014, 04:20
Báo cáo khoa học: Acceleration of disulfide-coupled protein folding using glutathione derivatives potx
... Department of Applied Chemistry, Faculty of Engineering, Tokyo University of Science, Yamaguchi, Japan Introduction The formation of the correct disulfide bonds and the conversion of a protein into its ... to accelerate the formation of the native disulfide bonds, thus resulting in an improved folding recovery. However, the role of the arginine residue of RCG in folding reacti...
Ngày tải lên: 06/03/2014, 00:21
Báo cáo khoa học: Control of mammalian gene expression by amino acids, especially glutamine potx
... the action of glutamine to regulate apoptosis and intermediary metabolism in different cell types and tissues. The signalling pathways leading to the acti- vation of transcription factors suggest ... No claim to original French government works. 1829 Transcription factors involved in the regulatory role of glutamine on cell proliferation, apoptosis and survival Different...
Ngày tải lên: 07/03/2014, 00:20
Báo cáo khoa học: Inhibition of PI3K/Akt partially leads to the inhibition of PrPC-induced drug resistance in gastric cancer cells pdf
... various steps in the cytotoxic activity of the drug, from a decrease of drug accumulation in the cell to abrogation of apoptosis induced by the chemical substance. Often several different mechanisms ... proportion of posi- tive cells was classified into five groups: 0, no tumor cells exhibiting IR; 1, < 25% of the tumor cells exhibiting IR; 2, 25–50% of the tumor cells exhi...
Ngày tải lên: 07/03/2014, 03:20
Báo cáo khoa học: Use of lithium and SB-415286 to explore the role of glycogen synthase kinase-3 in the regulation of glucose transport and glycogen synthase pdf
... muscle and fat cells. To gain some insight into this issue we subsequently monitored the effects of a number of inhibitors that target PI3K, the MAP kinase pathway, p38 MAP kinase and mTOR on Li-stimulated ... activation of PP1G rather than inactivation of GSK3 [26]. In an attempt to establish the importance of GSK3 in the acute regulation of glucose transport in terms of it...
Ngày tải lên: 08/03/2014, 08:20
Báo cáo khoa học: Secretion of macrophage urokinase plasminogen activator is dependent on proteoglycans potx
... factors and inflammatory mediators [26]. Tumor-associated macrophages have, e.g. been demonstrated to increase the expression of uPA when exposed to transforming growth factor-b [37]. ... availability of uPA and MMP-9. However, HX-xyl treatment does not lead to a complete inhibition of uPA release from the cells, despite an essentially total abrogation of the synthesis of intac...
Ngày tải lên: 08/03/2014, 08:20
Báo cáo Y học: Binding of Thermomyces (Humicola) lanuginosa lipase to the mixed micelles of cis-parinaric acid/NaTDC Fluorescence resonance energy transfer and crystallographic study ppt
... expect to observe comparable fluorescence signals whether a lipase molecule binds to the mixed micelle of cis-PnA/NaTDC or toa single molecule of cis-PnA incorporated into the mixed micelles. ... transformation of cis-PnA aggregates into mixed micelles of cis-PnA/NaTDC. The presence of mixed micelles of cis-PnA/NaTDC was also suggested by the increase in the fluorescence emissio...
Ngày tải lên: 08/03/2014, 23:20
Báo cáo khoa học: Prevalence of intrinsic disorder in the hepatitis C virus ARFP/Core+1/S protein doc
... (2008) The intrinsically disordered cytoplasmic domain of the T -cell receptor zeta chain binds to the Nef protein of simian immunodeficiency virus without a disorder -to- order transition. Biochemistry ... PL, Kolberg J & Urdea MS (1993) Classification of hepatitis C virus into six major genotypes and a series of subtypes by phylogenetic analysis of the NS-5 region. J Gen...
Ngày tải lên: 15/03/2014, 09:20
Báo cáo khoa học: Kinetics of electron transfer from NADH to the Escherichia coli nitric oxide reductase flavorubredoxin pdf
... (ONOO – [3]), all of which are cytotoxic towards the invading microbes. As a strategy to evade the host immune attack, pathogenic microorganisms have evolved biochemical pathways to resist to such a ... presence of an excess of NADH, two events can be deconvoluted: the reduction of [Fe-Cys 4 ] (monitored at 560 nm) and the formation of semiquinone FMN (monitored at 390 nm afte...
Ngày tải lên: 16/03/2014, 11:20