Báo cáo sinh học: "Deep sequencing of gastric carcinoma reveals somatic mutations relevant to personalized medicine" pptx
Báo cáo y học: " Transcriptome analysis of murine thymocytes reveals age-associated changes in thymic gene expression"
... Amplification Kit following manufac- tures protocols. In Short: Between 0.5μg to 2μg of total RNA was used to generate first and second strands of cDNA containing a T7 RNA polymerase promoter. ... further scrutiny. In order to obtain an expression profile of the genes which changed the most with age, we uploaded all of our array data into the array analysis program of t...
Ngày tải lên: 03/11/2012, 11:35
Tài liệu Báo cáo khoa học: ATPase activity of magnesium chelatase subunit I is required to maintain subunit D in vivo ppt
... domain of BchD into contact with the integrin-binding motif of BchH, simultaneously triggering porphyrin metallation. This would also lead to a release of the blockade of the ATP-binding site of ... logical to search for the function of BchI among the various functions of AAA + proteins. The AAA + proteins represent one type of molecular chaperones and their function is t...
Ngày tải lên: 19/02/2014, 12:20
Tài liệu Báo cáo khoa học: Allosteric modulation of myristate and Mn(III)heme binding to human serum albumin Optical and NMR spectroscopy characterization pptx
... properties of the Mn(III)heme–HSA adduct in the presence of myristate are similar to those of the B conformational state of HSA, suggesting that myristate binding to one or more modulatory sites possibly ... analysis of warfarin binding to human serum albumin: anatomy of drug site I. J Biol Chem 276 , 22804–22809. 26 Chuang VTG & Otagiri M (2002) How do fatty acids cause...
Ngày tải lên: 20/02/2014, 02:22
Báo cáo khoa học: Identification of carbonic anhydrase 9 as a contributor to pingyangmycin-induced drug resistance in human tongue cancer cells ppt
... medulloblastoma cells, perhaps because of the methylation of the promoter, and restoration of DKK1 expression can induce apoptosis and suppress colony formation [42]. As a suppressor of cancer, ... limitation of PYM-based chemotherapy. The mechanism of cellular resistance to PYM is not fully understood, but it is extremely important to understand it for successful treatment o...
Ngày tải lên: 06/03/2014, 22:21
Báo cáo khoa học: Alpha-oxidation of 3-methyl-substituted fatty acids and its thiamine dependence pptx
... highly reactive due to the nature of the thioester bond. Ultimately this leads to the formation of formyl-CoA and a 2-methyl-branched fatty aldehyde. Fig. 4. Alignment of the cofactor-binding consensus ... Properties of the enzymatic steps/enzymes of the a-oxidation pathway. The table gives an overview of the present knowledge of some of the properties of the enzymes inv...
Ngày tải lên: 08/03/2014, 02:20
Báo cáo khoa học: "Deep dependencies from context-free statistical parsers: correcting the surface dependency approximation" pptx
... category of the mother node. 12 In Fig- ure 1, for example, to would be an ADJP dependent of quick rather than a VP dependent of was; and Farmers would be an S dependent both of to in to point ... divides the process of CF tree enhancement into three phases. Each phase involves the identifi- cation of a certain subset of tree nodes to be oper- ated on, followed by the app...
Ngày tải lên: 08/03/2014, 04:22
Báo cáo khoa học: "Semantic Analysis of Japanese Noun Phrases: A New Approach to Dictionary-Based Understanding" doc
... result both of DBA and SBA. The precision of DBA, the ratio of correct analyses to detected anal- yses, was 77% (=137/(137+19+21)); the re- call of DBA, the ratio of correct analyses to potential ... Proceedings of COLING- A CL '98. Akira Shimazu, Shozo Naito, and Hirosato No- mura. 1987. Semantic structure analysis of Japanese noun phrases wirh adnominal parti...
Ngày tải lên: 08/03/2014, 06:20
Báo cáo khoa học: The use of recombinant protein and RNA interference approaches to study the reproductive functions of a gonad-stimulating hormone from the shrimp Metapenaeus ensis ppt
... an increase of about 25% of MeVg1 expression was recorded (Fig. 2B). Next, we performed an in vivo injection of rMeMIH-B into females to further confirm its gonad- stimulatory effect. To demonstrate ... vitellogenin-stimulatory factor of shrimp. Because of the existence of multiple forms of the CHH family neuropeptides, there may be a dis- crepancy in defining the function of...
Ngày tải lên: 16/03/2014, 05:20
Báo cáo khoa học: Structural studies of nucleoside analog and feedback inhibitor binding to Drosophila melanogaster multisubstrate deoxyribonucleoside kinase doc
... suicide gene into malignant cells in order to activate a prodrug that eventually may kill the cell. To be able to optimize the func- tion of dNK, it is vital to have structural information of dNK complexes. In ... on the top and bottom of hydro- phobic residues. Around this cavity, polar residues are positioned to form specific interactions to the sugar and the base of the...
Ngày tải lên: 16/03/2014, 06:20
Báo cáo khoa học: CpG methylation of the CENP-B box reduces human CENP-B binding pptx
... the C5 atom of cytosine by the action of methyltransferases. To evaluate the effect of CpG methylation on the CENP-B–DNA interaction, we modeled additional methyl groups at the C5 atoms of site ... Yokohama, Japan 2 Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan 3 Waseda University School of Sc...
Ngày tải lên: 16/03/2014, 18:20