... (CLDN1-NLS), there is increased expression of claudin-1 in the nucleus, but there are still large amounts of claudin-1 in the cytoplasm as well. B) All of the claudin-1 in the nucleus can be shuttled into ... expression of claudin-1 in the cytoplasm, with some nuclear expression of claudin-1. B) Treatment of these cells with PKA inhibitor results in nuclear translocation of claudin-1 in as little as 15 minutes, ... dysplasia–Clefting) also have compromised skin integrity, and this has been shown to correlate to the lack of claudin-1 and also to the loss of p63 (15). Further, we have previously shown that increasing...