Báo cáo hóa học: " Do quality of life, participation and environment of older adults differ according to level of activity?" pdf
Báo cáo khoa học: Hepatocyte growth factor activator (HGFA): a serine protease that links tissue injury to activation of hepatocyte growth factor pdf
... investigation of HGFA activation in vivo, as well as regulation of HGFA activity by endogenous protease inhibitors, including hepatocyte growth factor activator inhibitor-1 (HAI-1) and protein C inhibitor ... (2005) Hepsin activates pro-hepatocyte growth factor and is inhibited by hepatocyte growth factor activator inhibitor-1B (HAI-1B) and HAI-2. FEBS Lett 579, 1945–1950. 19 Itoh H...
Ngày tải lên: 15/03/2014, 11:20
Báo cáo khoa học: The Rab5 effector Rabaptin-5 and its isoform Rabaptin-5d differ in their ability to interact with the small GTPase Rab4 doc
... regulation of rapid recycling from early endosomes [16,17]. Second, Rabaptin-5 can participate in balancing and coordina- tion of endo- and exocytosis through interaction with Rabphilin, a regulator of ... effector but unlike Rabaptin-5, does not interact with the Rab4, presumably due to a disrupted Rab4 binding site, and is thus unlikely to provide a link to a Rab4-positive...
Ngày tải lên: 16/03/2014, 18:20
Báo cáo khoa học: Viral entry mechanisms: human papillomavirus and a long journey from extracellular matrix to the nucleus docx
... and colleagues, who used a large library of siRNA and inhibitors to interfere with known factors of endocyto- sis. Furthermore, they found that uptake of HPV16 does not occur via micropinocytosis ... the affinity of capsids to HSPG or results in the exposure of sites required for handover to a putative non-HSPG uptake receptor, which then triggers endocytosis. HPV entry M....
Ngày tải lên: 23/03/2014, 04:20
Báo cáo khoa học: Do N-terminal nucleophile hydrolases indeed have a single amino acid catalytic center? Supporting amino acid residues at the active site of penicillin G acylase pptx
... interaction of the aNH 3 + of SerB1 with the oxyanion and with the side chain of AB Fig. 2. Optimized structures of the TI of hydrolysis of acetanilide by QM calculations at the AM1 level (A) and of N,2-diphenyl- acetamide ... group nitrogen and the main chain carbonyl of GlnB23 leads to the formation of a TS similar to TS2b. The subsequent protonation of the n...
Ngày tải lên: 16/03/2014, 01:20
Báo cáo y học: "Do we need a critical care ultrasound certification program? Implications from an Australian medical-legal perspective"
... meaning to include anybody that the person may have a professional relationship with. In the case of a doctor-patient relation- ship, the patient is the doctor’s ‘neighbour’ and the doctor must ... patients. Similar to contractual duty, there is a duty on the doctor’s part to exercise reasonable care and skill in the provision of advice and treatment, and a duty to w...
Ngày tải lên: 25/10/2012, 10:02
Báo cáo y học: "Comparison between single antiplatelet therapy and combination of antiplatelet and anticoagulation therapy for secondary prevention in ischemic stroke patients with antiphospholipid syndrome"
... Tokuoka 2 , Shigeharu Takagi 3 1. Department of Neurology, Tokai University Tokyo Hospital; 2. Department of Neurology, Tokai University Hachioji Hospital; 3. Department of Neurology, Tokai ... combination of antiplatelet and an- ticoagulation therapy (target INR: 2.0-3.0; mean 2.4±0.3) for the secondary prevention of stroke according to a double-blind protocol. There w...
Ngày tải lên: 26/10/2012, 09:48
Tài liệu Báo cáo khoa học: TEC family kinases in health and disease – loss-of-function of BTK and ITK and the gain-of-function fusions ITK–SYK and BTK–SYK pptx
... phenotype of XLA and the potential of BTK and ITK inhibitors The outcome of defective BTK signaling in humans has been described previously in detail [26,27], and therefore we will only review this topic ... binding and mutation to tryptophan most probably causes instability of the SH2 domain. Thus, these patients had undetectable levels of ITK protein despite normal level...
Ngày tải lên: 14/02/2014, 18:20
Tài liệu Báo cáo khoa học: Competition between innate multidrug resistance and intracellular binding of rhodamine dyes pdf
... active pumping of the agents out of the cells and their pas- sive uptake [10,31] and (b) competition between the active pumping of the agents out of the cells and their intracellular binding to receptors and ... accumulation of dyes, and probably certain drugs, in the cytoplasm. On the other hand, high-affinity binding of these agents to intracellular receptors over-...
Ngày tải lên: 18/02/2014, 13:20
Tài liệu Báo cáo khoa học: A facile method for expression and purification of the Alzheimer’s disease-associated amyloid b-peptide pdf
... a scaleable and inexpensive purification procedure. Ab(1–40) and Ab(1–42) coding sequences together with added ATG codons were cloned directly into a Pet vector to facilitate production of Met-Ab(1–40) and ... E22K, E22Q and D23N), and the availability of a rapid and simple expression and purification protocol will facilitate large-scale investigations of the molecular det...
Ngày tải lên: 18/02/2014, 13:20
Tài liệu Báo cáo khoa học: Aldehydes release zinc from proteins. A pathway from oxidative stress⁄lipid peroxidation to cellular functions of zinc pptx
... for many of the biological effects of aldehydes. The zinc-releasing activity of aldehydes establishes relationships among cellular zinc, the functions of endogenous and xenobiotic aldehydes, and redox ... functions of zinc and MT against ethanol toxicity Both zinc and MT protect the liver and the heart against the toxic effects of ethanol [45–47]. The above results sugge...
Ngày tải lên: 19/02/2014, 06:20