... cofilin and Pi binding to F-actin is pertinent to the regulation of actin dynamics in the cell. Results Fluorescence measurements of the effect of Pi on the rate of cofilin binding to TRC–F-actin A convenient ... by closing the ‘main door’ of the nuc- leotide binding cleft. Taken together, cofilin binding transforms the nucleotide binding cleft of F-actin prot...
Ngày tải lên: 19/02/2014, 07:20
... binary classifiers, each of which has been trained to match a specific type 1 Other binnings did not significantly alter the performance of the models we trained, and so we used the above binning strategy ... is the {0,1}-valued word-feature vector for the event (resp: sentence). This value is simply the fraction of distinct words in e that are present in s. We then quant...
Ngày tải lên: 20/02/2014, 09:20
Báo cáo y học: "Clinical Strategy for the Management of Solid Pseudopapillary Tumor of the Pancreas: Aggressive or Less"
... 4-20). Nine patients had their tumors within the head, 2 in the body and 7 in the tail of the pancreas. Notably one patient was demonstrated to have liver metastasis. The predominant presenting ... Neoplasm of the pancreas (SPN) is the correct description regarding the terminology. 4,5,6 Despite the increases in recognition of characteristics of this tumo...
Ngày tải lên: 25/10/2012, 11:40
Báo cáo y học: "Human toxoplasmosis and the role of veterinary clinicians"
... role in the education of the human population regarding the risk of infection. Knowledge of the parasite’s biological charateristics, life cycle and trasmission routes is nec- essary to correctly ... “rules”, liv- ing with their pets need not represent any risk for infection with Toxoplasma gondii. Cats are the definitive host of T. gondii; they are the only animal...
Ngày tải lên: 03/11/2012, 11:06
Tài liệu Báo cáo khoa học: MicroRNA-23a promotes the growth of gastric adenocarcinoma cell line MGC803 and downregulates interleukin-6 receptor pdf
... vectors containing the mutations of the miR-23a binding site (Fig. 4A). It was shown that miR-23a ASO or pcDNA3 ⁄ pri-23a did not affect the intensity of EGFP fluorescence in the vector bearing the ... interacts with the first potential binding site of the IL6R mRNA 3¢ UTR. (A) The three EGFP reporter vectors bear- ing mutations of the miR-23a seed region binding sit...
Ngày tải lên: 18/02/2014, 04:20
Tài liệu Báo cáo khóa học: Further insights into the assembly of the yeast cytochrome bc1 complex based on analysis of single and double deletion mutants lacking supernumerary subunits and cytochrome b pdf
... cytochrome b protein was detectable in the CKL57 strain. We do not know whether the lack of immunoreactivity in the latter strain was due to the inability of the truncated protein to insert into and be ... 1211 Interestingly, the absence of subunit 6 also resulted in an increase in the ratio of intermediate to mature cyto- chrome c 1 and a disappearance of...
Ngày tải lên: 19/02/2014, 12:20
Tài liệu Báo cáo khoa học: cN-crystallin and the evolution of the bc-crystallin superfamily in vertebrates pdf
... lost the intron dividing the exons encoding the first domain. The next step in the evolu- tion of the c-crystallins was cS-crystallin, in which a second, symmetrical intron loss occurred to give the ‘modern’ ... pro- tein (XAP-1) expressed in the retina and associated with photoreceptor disc shedding [48]. In evolution, functional retinas preceded the evolution o...
Ngày tải lên: 19/02/2014, 17:20
Tài liệu Báo cáo khoa học: Oxygen tension regulates the expression of a group of procollagen hydroxylases docx
... by investi- gating the in uence of the UPR for the expression of the procollagen hydroxylases. With the exception of PDI, which is known to be induced by the UPR [41], however, none of the other ... the question arises concerning the mechanisms underlying the orchestrated expression of these enzymes by the oxygen tension. The findings that the effect of...
Ngày tải lên: 20/02/2014, 02:21
Tài liệu Báo cáo khoa học: Multidentate pyridinones inhibit the metabolism of nontransferrin-bound iron by hepatocytes and hepatoma cells docx
... sixfold increase in hepatocyte nonheme Fe. This strongly suggests a role for the liver in binding, storing and detoxifying excess body Fe in the form of plasma NTBI. While these hepatoma cells took ... proportion of Fe in the ferritin-free cytosolic compartment. This suggests that the chelators may also be acting intracellularly, inhibiting Fe incorporation into ferritin....
Ngày tải lên: 20/02/2014, 11:20
Tài liệu Báo cáo khoa học: Fra-1 targets the AP-1 site/2G single nucleotide polymorphism (ETS site) in the MMP-1 promoter docx
... appear unchanged in the presence of the inhibitor (–). Thus, a decrease in the expression of MMP-1 in the presence of PD098059 may be due, at least in part, to a decrease in the binding of transcription factors ... lgof 1G/2GMMP-1promoterconstructsdrivingaluciferasereporterand the pCl empty vector, or with increasing quantities of pCl fra-1 anti- sense (AS) v...
Ngày tải lên: 21/02/2014, 00:20