... important role in controlling viral load in the CNS and in preventing the development of TMEV-induced demyelinating disease following infection with a less virulent BeAn strain in mice of the susceptible ... the NLM. We further examined the viral loads in the CNS (brains and spinal cords) of both mouse groups at 7, 21 and 50 dpi using plaque assays (Fig. 2B). The levels of infectious virus in the ... MDA5 and PKR [16, 24] . Therefore, the relative role of TLR3-mediated signaling in the development of TMEV-induced demyelinating disease remains to be determined. In particular, the induction...