... tissue and gastrointestinal tract, as well as other sites, are known to reach the CNS to effect changes in feeding behavior and energy expenditure Thus, insulin, leptin and ghrelin, as well as other ... closely and rapidly with reciprocal changes in the levels of the orexigenic and anorectic Signaling mediators in the treatment of obesity neuropeptide expression in the hypothalamus [22] Thus an increase ... explored further Other areas of the brain have also been shown to regulate feeding via AMPK [35,36] Of interest is the extensive use of fructose as a sweetener in the human diet [37] Glucose and fructose...
Ngày tải lên: 14/02/2014, 22:20
... at each phase of the cell cycle by various complexes of cell-cycle-related molecules, including cyclins, cyclin-dependent kinases, their inhibitors and the retinoblastoma protein (RB), as well ... calorie intake induces expression of RMI1 and E2Fs in adipocytes, and these changes in expression are expected to increase a positive interaction between the molecules The increased expression of ... recruitment of preadipocytes [12], suggesting that these cyclin-dependent kinase inhibitors are important in the regulation of adipocyte number The S-phase kinase-associated protein (Skp)1–CullinF-box...
Ngày tải lên: 06/03/2014, 01:20
Báo cáo y học: "The opposite effects of fluvoxamine and sertraline in the treatment of psychotic major depression: a case report" potx
... fluvoxamine binds to sigma-1 receptors in the intact human brain at therapeutic doses [25], suggesting that sigma-1 receptors are involved in the active mechanisms of fluvoxamine [19] Interestingly, ... that activation of the dopaminergic system by the inhibition of dopamine transporter may be involved in the mechanism of unwanted effects (deterioration of psychosis) of sertarline in this case, ... effective in the treatment of psychotic major depression, and the switch to sertraline worsened the psychotic symptoms in the patient The mechanisms underlying the opposite effects of these two...
Ngày tải lên: 08/08/2014, 23:21
Báo cáo y học: " Comparison of the efficacy of lamivudine and telbivudine in the treatment of chronic hepatitis B: a systematic review" pdf
... approved the final manuscript Competing interests The funding source had no influence on study design, in the collection, analysis, and interpretation of the data, in the writing of the manuscript, ... of the healthcare system is not satisfactory There are limitations in the reimbursement of anti-HBV therapy, either in the selection of agent or the duration of dosing Therefore, lamivudine and ... telbivudine are more widely used in treatment of CHB In this systematic review, we focus on the comparison of the efficay of lamivudine and telbivudine in the Figure Effect of telbivudine vs lamivudine...
Ngày tải lên: 12/08/2014, 01:21
Báo cáo khoa học: " Science review: Carnitine in the treatment of valproic acid-induced toxicity – what is the evidence" pot
... pathophysiology and significance of VPA-induced carnitine deficiency and evaluated the literature pertaining to carnitine supplementation during VPA therapy in children Despite the lack of prospective, randomized ... further investigations in controlled, randomized and probably multicentre trials to evaluate the clinical value and the appropriate dosage of L-carnitine in each of these conditions Competing interests ... [38] Administration of exogenous carnitine is thought to decrease ammonia levels by binding to VPA, thereby enhancing the β-oxidation process and production of acetyl-CoA, and relieving the inhibition...
Ngày tải lên: 12/08/2014, 22:22
Báo cáo y học: "Formulas Vasopressin and epinephrine in the treatment of cardiac arrest: an experimental study" docx
... pressures and short-term survival, in comparison to the single use of epinephrine This study adds some evidence to the existing literature of the epinephrine-vasopressin combination benefits and further ... vasoconstrictive Page of (page number not for citation purposes) effect of the combination of the two drugs in comparison to epinephrine alone in the first minute of CPR with an increase of CPP This increase ... interpretation of the clinical outcome in vasopressin studies The authors recognize several limitations in the interpretation of the present findings The study was conducted on apparently healthy pigs and...
Ngày tải lên: 13/08/2014, 08:21
Báo cáo y học: " Vacuum-assisted closure in the treatment of early hip joint infection"
... [16] and the possibility of costs minimization [8, 14] The disadvantage of lacking inspections of the sponges can be compensated by daily controlling of the canister fluid and monitoring of the inflammation ... of an endoprosthesis involving the local tissue and causing an immune reaction [15] The most common problem hereby is the draining sinus, prolongating and preventing wound healing The pathophysiological ... haemodynamics, the surrounding tissue is decompressed and local microcirculation is re-established The increase of the oxygen gradient facilitates the transportation of toxins and inhibitors inducing thereby...
Ngày tải lên: 26/10/2012, 09:53
Báo cáo khoa học: "Intraoperative radiation therapy in the treatment of early-stage breast cancer utilizing xoft axxent electronic brachytherapy" ppt
... approximately 15 minutes, the physicist then loaded the corresponding radiation plan onto the controller unit contaminating the field The catheter end was passed through a hole in the drape and a FlexiShield™ ... Results The radiation oncologist then broke scrub, attached the XB controller to the catheter, and inserted the radiation source into the balloon The radiation therapy was then Figure and no evidence ... cavity through a small incision in the lateral breast and inflated with exactly 40 cc of saline (Figure 1) The conformity of the CED to the surrounding breast tissue was then evaluated under direct...
Ngày tải lên: 09/08/2014, 04:21
Báo cáo y học: "A randomized, double-blind, placebo-controlled trial to assess the efficacy of topiramate in the treatment of post-traumatic stress disorder" pot
... for PTSD is challenging due to the complexity of the symptoms and psychiatric comorbidities Psychotherapy and pharmacotherapy are the two main classes of PTSD treatment In the Cochrane systematic ... three symptom clusters of PTSD, as well as alleviating the symptoms of depression, and in improving the quality of life measures The current evidence base of randomized clinical trials is unable ... arousal [15,16] The implication of the limbic kindling-like phenomenon in the pathophysiology of PTSD has stimulated clinical research in antiepileptic drugs in the treatment of PTSD Topiramate...
Ngày tải lên: 11/08/2014, 17:20
Báo cáo y học: "Special considerations in the treatment of patients with bipolar disorder and medical co-morbidities"
... 2004, of portacaval shunting, thereby decreasing first pass metabolism; decrease in quantities and affinity of plasma proteins, thereby increasing free-drug levels; increase in volume of distribution ... syndrome), including carbamazepine, phenytoin, phenobarbital, and lamotrigine The triad of hypersensitivity includes fever, rash and internal organ involvement with onset of symptoms within to weeks of ... pre-dialysis and 2–3 hrs following the post-dialysis dose There is a case report in which lithium levels were maintained in the therapeutic range by intraperitoneal administration of lithium during continuous...
Ngày tải lên: 25/10/2012, 10:51
Báo cáo y học: " Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: a clinical trial"
... provide written informed consent Use of other natural health products, including glucosamine and chondroitin, one month prior to study and during the study, other than multivitamin and mineral supplements ... capsule contains 375 mg of glucosamine HCl (USP Grade) and 300 mg of chondroitin sulfate (USP Grade) The subjects were instructed to take two G+C capsules in the morning and two in the evening for ... acetaminophen or ibuprofen within days of randomization Subject is unwilling to stop taking pain medication other than the study medication (for arthritis or other types of pain) or is unwilling...
Ngày tải lên: 26/10/2012, 09:48
WORMS: IDENTIFYING IMPACTS ON EDUCATION AND HEALTH IN THE PRESENCE OF TREATMENT EXTERNALITIES ppt
... These results are largely robust to including the proportion of Group pupils in the surrounding area as the explanatory variable, rather than the total number of Group pupils in the surrounding ... treatment in 1998 This was partly because of confusion in the field about pupil age, and partly because in the early stages of the program several of the Kenya Ministry of Health nurses administered ... To the extent that children in Busia also self-treat helminth symptoms with herbs, in this study we measure the net benefit of deworming drugs above and beyond the impact of herbs and of any individually...
Ngày tải lên: 22/03/2014, 15:20
From certainty to uncertainty the story of science and ideas in the 20th century
... the quantum theory The only uncertainty, according to Einstein, lay in our inability or lack of ingenuity in measuring the objective properties of such systems When Bohr and Einstein met at the ... totally independent of the state of the observer This is the deeper meaning of Einstein’s great discovery Behind all phenomena are laws of nature, and the form of these laws, their most elegant mathematical ... On Incompleteness 29 Mathematics: The Ultimate Certainty? And so we turn to mathematics for a final certainty and begin with one of the simplest and purest operations the act of counting Of all...
Ngày tải lên: 09/04/2014, 16:38
networks of innovation change and meaning in the age of the internet
... world of objects, but in society and in minds More particularly, it happens in the minds of the users, which are intrinsically integrated with the activities of the users Those cultural and material ... outlining the history of the World Wide Web It asks who invented the Web, what were the resources used in its invention, and what actually was invented in the process Many of the details of this ... that there is a normal way of using the phone, and a corresponding standard interpretation of the meaning of the thing In some circumstances a telephone may be a perfect hammer; most of the time,...
Ngày tải lên: 01/06/2014, 10:08
báo cáo hóa học:" Granuloma debridement and the use of an injectable calcium phosphate bone cement in the treatment of osteolysis in an uncemented total knee replacement" doc
... screening including erythrocyte sedimenta- Page of tion rate and C-reactive protein was normal Plain radiographs revealed areas of periprosthetic osteolysis in the femur and the tibia, and a ... image of the left knee showing the introducing cannula and simultaneous venting of the medial tibial condylar cyst Discussion When dealing with massive periprosthetic osteolysis the aims of surgery ... years later In January 2005 the patient began to develop similar medial pain and swelling in the left knee A bone scan showed increased activity in the medial femoral condyle indicating possible...
Ngày tải lên: 20/06/2014, 04:20
báo cáo hóa học:" Effects of GnRH agonist treatment on steroidogenesis and folliculogenesis in the ovary of cyclic mice" pot
... caspase-3 and cleaved PARP proteins in mice Increase in the expression of caspase-3 and cleaved PARP proteins noticed in the mice treated in vivo with GnRH-Ag also showed increase in the number of atretic ... receptors, and steroidogenic and apoptotic factors in the ovary was investigated following in vivo and in vitro administration of GnRH agonist in the intact cyclic mice Methods Animals All the experiments ... planned and executed the experiments, responsible for data interpretation and writing of the manuscript, AK helped in planning and supervised the work, participated in data analysis and interpretation...
Ngày tải lên: 20/06/2014, 07:20
báo cáo hóa học:" eJIAS: The Journal of HIV/AIDS Science and Medicine in the Developing World" docx
... Journal of the International AIDS Society 2004, 6:56 http://www.jiasociety.org/content/6/3/56 sharing, and education that must attend expanding global HIV/AIDS care initiatives Authors and Disclosures ... Bio Med Central and every scientist can read your work free of charge "BioMed Central will be the most significant development for disseminating the results of biomedical researc h in our lifetime." ... grants for clinical research and/ or honoraria for educational and/ or advisory activities from Bristol-Myers Squibb, Boehringer Ingelheim, Gilead Sciences, GlaxoSmithKline, Idenix, Merck, and Roche...
Ngày tải lên: 20/06/2014, 08:20
Báo cáo y học: "Efficacy and safety of aripiprazole in the treatment of bipolar disorder: a systematic review" pdf
... Annals of General Psychiatry 2009, 8:16 the treatment of acute mania, the approval of quetiapine and the olanzapine-fluoxetine combination against acute bipolar depression and the approval of olanzapine, ... dose at the end of the study was 15.5 mg daily The results suggest that in weeks to and then again at week there is a significant reduction in the MADRS scores in the aripiprazole group in comparison ... aripiprazole at the end of the 74-week period was 23.6 mg daily It is reported that 29 out of the 66 patients relapsed (16 out of the 39 in the aripiprazole group (41%) and 13 out of the 27 in the placebo...
Ngày tải lên: 08/08/2014, 23:21
Báo cáo khoa học: "Factors of influence upon overall survival in the treatment of intracranial MPNSTs. Review of the literature and report of a case" doc
... contributions All of the authors have been involved in drafting this paper and have read and approved the final manuscript KG conceived the idea of the paper, reported the case, performed the literature ... concerning radiotherapy and followed up the patient at his out-patient clinic AK was the radiologist performing the preoperative and postoperative CT and MRI scans and wrote the part of the paper ... radiotherapy and conventional fractionation while minimising the risks of RT-inducing brain injury like radiation necrosis and cognitive decline The optimal radiation dose has not yet been defined We...
Ngày tải lên: 09/08/2014, 09:20