Báo cáo sinh học: "Research downsizing, mergers and increased outsourcing have reduced the depth of in-house translational medicine expertise and institutional memory at many pharmaceutical and biotech co" pdf

... Access Create a translational medicine knowledge repository - Research downsizing, mergers and increased outsourcing have reduced the depth of in-house translational medicine expertise and institutional ... Marincola: Create a translational medicine knowledge repository - Research downsizing, mergers and increased outsourcing have reduced...

Ngày tải lên: 18/06/2014, 19:20

... clinical, laboratory and pharmacy information for all patients, including the dates of enroll- ment into the HIV clinic, the dates of all clinical appoint- ments and CD4 tests and the dates of starting ... evaluated the bivariate association between the number of patients starting HAART and the study month and site. We then used multivariate linear regression t...

Ngày tải lên: 18/06/2014, 17:20

... through compilation of data at the facility level for returns to district health offices, during compilation at the district level for reporting to national l evel, and in analysis at the national ... shown). The value of staff-population density calculations is more limited in areas where there is a mixture of gov- ernment and non-government (for-profit and non- pro...

Ngày tải lên: 18/06/2014, 17:20

... levels of blood urea nitrogen (BUN) and creatinine, urine amount, and the ratio of urine protein to creatinine. Serum levels of blood urea nitrogen (BUN) and creatinine and the ratio of urine ... translo- cation of HO-1. Chen et al. Journal of Translational Medicine 2011, 9:51 http://www .translational- medicine. com/content/9/1/51 Page 14 of 17 dysfunction [7,1...

Ngày tải lên: 18/06/2014, 19:20

... presents the values of the KS criteria between simulated results and the four theoretical distributions and the values of the estimated parameters of the distributions, for the three zones. The ... point of the considered path, as illustrated in Figure 2. The parameters vector contains the coordinates of the interaction points of the path. The it...

Ngày tải lên: 18/06/2014, 22:20

... influencing the abnormal proliferation and movement of gastric epithelial cells related to gastric atrophy via the activation of ERK. This study also showed that the gastric atrophy risk ... activation [13-17]. The activated SHP-2 is associated with Gab1 to mediate EGF-stimulated ERK2 activation, and Gab1 is the SHP-2 activator for the ERK MAP kinase pathway in EGF-s...

Ngày tải lên: 31/10/2012, 15:37

... implicated in regulating the cell division of M. tuberculosis [19,20]. One of the major gaps in our knowledge concerns identification of the key substrates of protein kinases and phosphatases and ... to the inactive ⁄ resting state would require either the synthesis of new proteins or the de- phosphorylation of the existing phosphorylated species. The only repor...

Ngày tải lên: 16/03/2014, 14:20

... the O 6 and N 7 atoms of G 13 (complementary to the conserved C 8 base on the sense strand) and the N 7 atom of A 12 (complementary to the conserved T 9 base on the sense strand [17]). The M. ... cessa- tion of active bacterial growth and the transition into a non-replicative persistent state. An understanding of the molecular basis of dormancy is a prerequis...

Ngày tải lên: 22/03/2014, 16:20

... trafficking of NCT. Effect of Synoviolin on the production of Ab NCT is one of the essential cofactors of the c-secretase complex. We therefore investigated the effect of the Synoviolin-mediated degradation ... ubiquitination also regulates the traffick- ing of NCT within the Golgi compartment, because the maturation of the sugar modification of the pro- tei...

Ngày tải lên: 23/03/2014, 04:20

... (data not shown). These results indicate that the mutations had no effect on the secondary and tertiary structure arrangements of the protein and suggest that, in the native state, the effect of ... importance of each vector in U and V. The signal-to-noise ratio is very high in the earliest columns of U and V and the random noise is mainly accumulated in the...

Ngày tải lên: 30/03/2014, 04:20