Báo cáo sinh học: "Differentiation associated regulation of microRNA expression in vivo in human CD8+ T cell subsets" doc

... quantitative PCR in several human CD8 + T cell subsets defining the major steps of the T cell differentiation pathway. Results: We found expression of a limited set of microRNAs, including the ... not all members are regulated concomi- tantly, indicating a differential intra-cluster regulation in agreement with the TLDA results (Table 1). Altogether, the data presented...

Ngày tải lên: 18/06/2014, 19:20

... quantitative PCR in several human CD8 + T cell subsets defining the major steps of the T cell differentiation pathway. Results: We found expression of a limited set of microRNAs, including the ... differentiation and functional properties. In that respect, it might therefore be helpful to elaborate better vaccination strategies for induction of CD8 + T cells with app...

Ngày tải lên: 20/06/2014, 03:20

... results suggested that in- vivo stimulation of ECM protein deposition would most likely be inhibited, due to the increased expression of Smad-7, which inhibits TGFb1- activity. In contrast to skin ... related to oral mucosa soft tissue repair in BRONJ. Our findings indicated that BRONJ was associated with an impair- ment in TGFb1 signaling that was dif ferent than that assoc...

Ngày tải lên: 18/06/2014, 19:20

... example of ultrastructural changes to a hepatocyte from one of the fatally infected rabbits. Note the margination of chromatin (Ch) in the nucleus (Nu), and disruption of cristae in mitochondria ... phylogenetic link between individual U.S. outbreaks and Chinese isolates indicated that each of the U.S. outbreaks were the result of a separate introduction of virus. Once aga...

Ngày tải lên: 18/06/2014, 18:20

... different substitution rate [24]. The DR model is used as suitable general model against which to test the assumption of constant rates of the fit of the single rate (SR) and the single rate dated ... very stable. Another report suggested that two distinct genotypes of HPIV were detected during the Detailed genetic analysis of hemagglutinin- neuraminidase glycoprotein gene in...

Ngày tải lên: 18/06/2014, 18:20

... filter-based tracking algorithm. In addition, Badali et al. [15]investigated the accuracy of different time delay of arrival estimation audio localization implementations in the context of artificial audition ... cluster is defined as a set of sound source direction data points. For a cluster, the data within this cluster should be similar to one another and it means that the data wit...

Ngày tải lên: 21/06/2014, 16:20

... (AP-1) triggers the expression of miR-21 through binding to several AP-1 binding sites that are found in the promoter of the gene for miR-21. Taken together, these studies suggest that miR-21 acts ... regu- lators of ERK signaling, indicates that miR-34a is involved in negative-feedback regulation of the ERK signal cascade. These studies indicate that a compli- cated regulator...

Ngày tải lên: 14/02/2014, 19:20

... inhibitory proteins at the CDE ⁄ CHR. It was shown that E2F4 binds to the CDE and that Lin-54 binds to the CHR in the Cdc2 promoter in G 0 . It is probable that these proteins constitute part of the DREAM ... transcriptional start sites Protein binding to the elements in G 0 and G 1 cells as monitored by in vivo footprinting Mutation of either CDE or CHR leads to a substantial d...

Ngày tải lên: 16/02/2014, 09:20

... postulated that splitomicin acted by preventing the binding of acetyl- ated lysine substrates to ySir2. However, it is import- ant to point out that the in vitro assays were performed on whole cell ... SIRT4, 6 and 7 exhibit specificity toward substrates other than those tested or that these proteins catalyse a distinct reaction. Keywords Sir2; deacetylation; sirtuin; NAD; sirtinol; spli...

Ngày tải lên: 20/02/2014, 01:20

... hypoxia treatment. Since the NAD overlaps with the ODD its increase in transcriptional activity at hypoxia was largely attributed to increased protein stability [75]. However, the increase in transcrip- tional ... transcrip- tional activity of the CAD was not attributed to changes in protein level [75]. Instead, hypoxia was suggested to promote the recruitment of transcriptional coa...

Ngày tải lên: 20/02/2014, 23:20