Báo cáo sinh học: "Histone modification enhances the effectiveness of IL-13 receptor targeted immunotoxin in murine models of human pancreatic cancer" doc

... Fujisawa et al.: Histone modification enhances the effectiveness of IL-13 receptor targeted immunotoxin in murine models of human pancreatic cancer. Journal of Translational Medicine 2011 9:37. Submit ... RESEARC H Open Access Histone modification enhances the effectiveness of IL-13 receptor targeted immunotoxin in murine models of hu...

Ngày tải lên: 18/06/2014, 19:20

... and the flanking chromatin [9]. These findings indicate that the action of DSB-interactive proteins within the nuclear micro- environment must be coupled with the mobile state of those proteins. Keywords coacervate; ... (ii) the concentration of factors diluted in solution; (iii) the acceleration of reactions; and (iv) the involvement of DNA aggrega- tion-promoting fac...

Ngày tải lên: 19/02/2014, 06:20

... that the nicking of the 123- residue chain polypeptide chain causes an untighting of the structural domains of LA (see Fig. 1), determin- ing exposure of hydrophobic patches. Furthermore, the ... at the level of the b-subdomain of the 123- residue chain of the protein (Fig. 1). We have also characterized the early stages of protein aggregation in order to g...

Ngày tải lên: 30/03/2014, 16:20

... gives a clear indication of the inade- quacy of adopting a strategy of training and employing mid-level cadres in the absence of strategies to strengthen and improve other aspects of the health ... each of the three geographical regions in Malawi. A total of 34 health facilities from the three districts were included in the study. All staff in each of the...

Ngày tải lên: 18/06/2014, 17:20

... process enables the UNMC to fulfil its social contract of main- taining a minimum standard of nursing care, thereby instilling public confidence in the health care system. At the time of this writing, the ... was used during meetings with the MOH, the Ministry of Public Service, and the Ministry of Finance, as an evi- dence-based advocacy tool to encourage increasing...

Ngày tải lên: 18/06/2014, 17:20

... regained neurovirulence indicated that mutations mapping to the 5'NTR specified the att phenotype of the three Sabin strains. Attenuating point mutations within the 5'NTR of the Sabin ... between the Sabin OPV strains and closely related viruses has come into the limelight. Indeed the propensity of OPV strains to recom- bine in recipients of the vaccine h...

Ngày tải lên: 18/06/2014, 18:20

... prognostic factor. Otherwise,themastcellcountintheinvasivemargin was associated with neither the clinicopathlogic para- meters nor overall survival, since the mast cell in the cancer stroma was ... it. In addition to infiltrating primary tumors, mast cells also infiltrate metastases. The role of mast cells in metas- tasisisstillnotknown.Therefore,thisstudyexamined the infilt...

Ngày tải lên: 18/06/2014, 19:20

... tuberculin syringe was inserted through the second intercostal space to the left of the sternum, into the left ventricle. When blood ente red the tip of the needle, 5 × 10 4 viable cancer cells in ... CF-AM-labeled and after washing, they were added (5 × 10 4 cells/well) to quadruplicate wells. Then, plates were incubated for 30 min, in the case of B16M cells, or for 6...

Ngày tải lên: 18/06/2014, 22:20

... q + k  i=1  k i  (−1) i i q i − 1  . Here, the term with i = 0 is understood to be 1/log q (the limiting value of the summand in the limit i → 0). Specifically, by making use of the following well- known binomial identity k  k ... Z p , Q p , and C p denote the ring of p-adic integers, the field of p-adic numbers, and the completion of the algebraic closure of...

Ngày tải lên: 18/06/2014, 22:20

... protein with a distinctively shorter N- terminus than the wild-type form [6]. Protein 3a is one of the SARS-CoV accessory proteins and the expression of the 3a protein has been demonstrated during ... during both in vitro and in vivo infection [5]. To determine if the mutation arises from repeated passages of the virus or if the mutation exists in the virus that is...

Ngày tải lên: 19/06/2014, 08:20