Báo cáo sinh học: "Alpha-1 antitrypsin protein and gene ther

Báo cáo sinh học: "Alpha-1 antitrypsin protein and gene therapies decrease autoimmunity and delay arthritis development in mouse model" potx

... drug for arthritis therapy. Human AAT protein and gene therapies are able to ameliorate and delay arthritis development and reduce autoimmunity, indicating promising potential of these therapies ... as a serine proteinase inhi- bitor (serpin). It inhibits proteinase 3, neutrophil elas- tase, and cathepsin G. These serine proteases are released by joint invading neutro...

Ngày tải lên : 18/06/2014, 19:20

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Báo cáo sinh học: " Relationship between the loss of neutralizing antibody binding and fusion activity of the F protein of human respiratory syncytial virus" doc

... function of the F protein, and help in the selection and development of clinical candidates, such as ch101F, for next generation antibody-based prophylaxis and therapy for HRSV infections. Abbreviations HRSV ... only a sin- gle change in lysine residue 433 to threonine suggesting that there are additional constraints on this region of the protein that limit which amino acids ch...

Ngày tải lên : 18/06/2014, 18:20

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Báo cáo khoa học: b-Amyloid protein oligomers induced by metal ions and acid pH are distinct from those generated by slow spontaneous ageing at neutral pH docx

... aggregation measured in a CR binding assay and that obtained with a sedimentation assay. In a CR binding assay, Fe 2+ , Zn 2+ and Cu 2+ were approximately equipotent in stimulating Ab aggregation, whereas in a ... at the N-terminus of Ab, in the region of the histidines (residues 6, 13 and 14). Furthermore, several studies have shown that histidine 13 and 14 are involved in...

Ngày tải lên : 31/03/2014, 07:20

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Báo cáo sinh học: " The E5 protein of the human papillomavirus type 16 down-regulates HLA-I surface expression in calnexin-expressing but not in calnexin-deficient c" pptx

... E5 decreases HLA-I surface expression in calnexin-containing but not in calnexin-deficient cellsFigure 2 HPV16 E5 decreases HLA-I surface expression in calnexin-containing but not in calnexin-deficient ... and proteins in the immune complexes were probed using anti-AU1 and anti-calnexin antibodies. C) Immunoprecipitations were performed using monoclonal anti-calnexin antibodie...

Ngày tải lên : 18/06/2014, 18:20

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Báo cáo sinh học: " Rotavirus nonstructural protein 1 antagonizes innate immune response by interacting with retinoic acid inducible gene I" pdf

... β-TrCP: β-transducin repeat containing protein, RIG-I: retinoic acid inducible gene I, MAVS: mitochondrial antiviral- signaling protein, JAK: Janus Kinase, STAT: Signal Transducer and Activator ... signaling pathway. This activity is unrelated to its IRF3 binding ability. Our findings provide insight into the pathogenesis of rotavirus infection and new knowledge in the path to fi...

Ngày tải lên : 18/06/2014, 18:20

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Báo cáo sinh học: "A case study of the College English Test and ethnic minority university students in China: negotiating the final hurdle" pptx

... Shun Ling. 2007. Bilingual or multilingual education in China: policy and learner experience. In Bilingual education in China, ed. Anwei Feng. 13–33. Clevedon, UK: Multilingual Matters. Ministry ... education, and there are booming mar kets in private tuition and eveni ng schools for children and adults, and in books, magazines, on-line learning and educational resources...

Ngày tải lên : 18/06/2014, 18:20

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Báo cáo sinh học: "High ERCC1 expression predicts cisplatin-based chemotherapy resistance and poor outcome in unresectable squamous cell carcinoma of head and neck in a betel-chewing area" pdf

... assess ERCC1 expression in pretreatment biopsy specimens from paraffin blocks. Clinical parameters, including smoking, alcohol consumption and betel nuts chewing, were obtained from the medical ... adducts, which cause inter- and intras- trand cross-linking. These DNA cross-links are recognized and removed by the nucleotide excision repair pathway which arms to guard the integrity of...

Ngày tải lên : 18/06/2014, 19:20

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Báo cáo sinh học: "A predicted protein, KIAA0247, is a cell cycle modulator in colorectal cancer cells under 5-FU treatment" ppt

... CRC carcinogenesis [37]. There- fore, early during CRC carcinogenesis, an effect ive cyto- toxic effect induced by 5-FU in the KIAA0247- expressing cells could be crucial in controlling the G2/ M ... therapies and earlier diagnosis [3-5]. Genes involved in cell growth, cell cycle, apoptosis, angiogenesis, or invasion could have a crucial role in CRC tumorigenesis [6,7]. In parti...

Ngày tải lên : 18/06/2014, 19:20

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Báo cáo sinh học: " No relationship between the distribution of mast cells and the survival of stage IIIB colon cancer patients" pdf

... the immunohistochemical staining. ZJ and ZQ analyzed the results. ZXS conceived the study, participated in the study design, and coordinated the writing and helped draft the manuscript. All authors read and approved ... substrate-chromogen solution [3,3’-diaminobenzi- dine dihydrochloride (DAB)] for 3-5 minutes. Sections were then counterstained with hematoxylin and mounted in n...

Ngày tải lên : 18/06/2014, 19:20

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