báo cáo hóa học: " Development and psychometric assessment of the COPD and Asthma Sleep Impact Scale (CASIS)" pdf
báo cáo hóa học: " Development and psychometric assessment of the COPD and Asthma Sleep Impact Scale (CASIS)" pdf
... measures and extend our understanding of the impact of respiratorydisease symptoms on sleep impact and quality.Given the prevalence of sleep problems in patients with asthma or COPD and the absence ... Development and validation of the Asthma Life Impact Scale [ALIS],submitted) during the baseline visit or survey. COPD and Asthma Sleep Impact Scale The 15-item CASIS incorporated items on sleep impair-ment ... assess the impact on sleep due torespiratory disease, the COPD and Asthma Sleep Impact Scale (CASIS).Methods: Identification of the items forming the CASIS was guided by patient interviews and...
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Báo cáo hóa học: " Functional polymorphisms in genes of the Angiotensin and Serotonin systems and risk of hypertrophic " ppt
... modifier of the extent of the hypertrophy in our pop-ulation, in patients with and without sarcomeric muta-tions. The role of the AT 1R SNP as a modifier of the phenotype was also supported by the ... polymorphisms at thesegenes. We also determined the effect of these gene poly-morphisms on onset age and the extent of the hypertro-phy.MethodsPatients and controlsThis study was part of a research ... measured, and the left ventricular wall thickness (LVWT) calculatedas the sum of IVS and PWT.Table 1 summarizes the main characteristics of patients. All them fulfilled the next inclusion criteria:they...
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Báo cáo hóa học: " Phase I clinical trial of the vaccination for the patients with metastatic melanoma using gp100derived epitope peptide " pot
... wrote the draft of the manuscript. HT participated in the design of the study, and carried out the clinical research. AK, AI, NO, YI participated in the conduct and datamanagement of the clinical ... ELISPOT and MHC-Dextramerassay ELISPOT and the MHC-Dextramer assay are shown in the left (a, e, i, c, g and k) and right (b, f, j, d, h and l) side of each panel. The arrowindicates the timing of ... by the non-cancerous mel-anocytes. The Fig. 1A shows vitiligo at the posteriorportion of the neck i n P2, and Fig. 1B showed vitiligo at the anterior tibial portion of the left leg in P3. The...
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báo cáo hóa học: " Cultural adaptation into Spanish of the generalized anxiety disorder-7 (GAD-7) scale as a screening tool" pot
... complete the scale. Conclusion: After the cultural adaptation process, a Spanish version of the GAD-7 scale was obtained. The validity of its content and the relevance and adequacy of items in the ... administeredto the sample of patients and controls together withthree other instruments: the Hamilton Anxiety Scale (HAM-A) [14], the Hospit al Anxiety and Depression Scale (HADS) [15], and the WHO-DAS ... uses of the GAD-7 scale similar to those of HAM-A and HADSshould not be dismissed. Indeed, the good performance of the new scale and its short administration timeshould be advantageous and provide...
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Báo cáo khoa học: Functionally active fusion protein of the novel composite cytokine CLC/soluble CNTF receptor pdf
... feature of the a receptor componentsbelonging to the IL-6 family is their ability t o promote the action of their ligands. These have been described indetail for IL-6/IL-6R, CNTF/CNTFR and IL-11/IL-11R[23,36,37]. ... esidues1–286 of CNTFR were modeled by homology with gp130(PDB accession numbers: 1BQU for the cytokine-bindingdomain of gp130 and 1I1R for the Ig-like and the CBDdomains of gp130 i n the complex ... expressed by their receptor c omplex. Analysis of the downstream signaling events revealed the recruitmentby CC–FP of the signal transducer and activator of tran-scription (STAT)-3, Akt and mitoge...
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báo cáo hóa học: " Development and psychometric validation of a self-administered questionnaire assessing the acceptance of influenza vaccination: the Vaccinees'''' Perception of Injection (VAPI©) questionnaire" docx
... constituted of two-thirds of the UK clinical trial subjects. The scale structure was then validated in the remaining one-third of the "UK validation population", to assess the robustness of the ... between the severity of each reaction reported for 8 days after the injection using the verbal rating scale, and the respective items of the "bother from ISR" dimension of the questionnaire ... instrumentsthat assess the importance and the acceptability of ISR tosubjects and the impact of these on subjects' daily life, aswell as the overall acceptance of the administration route.Investigations...
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báo cáo hóa học: " Development and validation of the Brazilian version of the Attitudes to Aging Questionnaire (AAQ): An example of merging classical psychometric theory and the Rasch measurement model" pptx
... suggested by the EFA. The Brazilian dataset showed coefficients of .863 for the Subscale I (and .845 for the International dataset),.804 for the Subscale II (.822 for the International sam-ple) and ... studiesreliably.Another relevant issue regarding the findings of the AAQvalidation is the construct similarity between the interna-tional sample and the Brazilian one. The three factors pro-posed by the ... indicate that the per-ception of aging did not differ significantly between the two samples and raises the question of whether these sim-ilarities remain or not in other different cultures. The demonstration...
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Báo cáo hóa học: " Development and application of a biomarker assay for determining the pharmacodynamic activity of an antagonist candidate biotherapeutic antibody to IL21R in whole blood" pptx
... cells[16-18]. The activities of IL21 have been shown to behighly dependent on the lineage of the target cell, the activation state of the target cell and the presence of otherco-stimulators and immune ... here, analyzed the data and co-wrote the manuscript. SJ and AAW performed all the pilot studiesin humans and monkeys that identified the candidate biomarkers, and theyparticipated in the data analyses. ... drafting of the manuscript. DY co-led the Ab-01 team and was responsible for studies relatedto the characterization of the biological properties of the antibody. LB co-led the Ab-01 team and was...
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Báo cáo hóa học: " Development of targeted therapy for bladder cancer mediated by a double promoter plasmid expressing diphtheria toxin under the control of H19 and IGF2-P4 regulatory sequences" potx
... ISH and the expression levels of IGF2-P4 and H19 transcripts were determined by the intensity of the hybridization signal and by the quantity of the stainedcells. Table 3 shows that out of 28 ... early studies of our group and others, the transcriptional regulatory sequences of the H19 and IGF2genes emerged as candidates for cancer targe ted therapy.H19 and IGF2 (the human P3 and P4 promoters) ... cycles of 94°C for 30 sec, 59°C for45 sec and 72°C for 60 sec, and finally 72°C for 5 min. The PCR reactions were carried out in 25 μlvolumesinthepresenceof6ng/μl of each of the forward and the reverse...
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báo cáo hóa học: " Development and preliminary evaluation of a quality of life measure targeted at dementia caregivers" doc
... and the development of caregiverstress and burden [5]. Families often report that behavio-ral disturbances are the primary source of stress and the primary cause for institutionalization of their ... of caregiving (p 0.05)). In con-trast, there were few associations of duration of being acaregiver and caregiver quality -of- life scores. Non-whiteethnicity of both the caregiver and of the ... standard error or 0.076 of each other), and items thathad no item -scale correlation greater than 0.35 wereexcluded from the final measure. Scale scores were calculated by taking the mean of the final...
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