... vGPCR induces COX-2 expression in primary vascular endothelial cells and may be responsible for the COX-2 and PGE 2 increases observed following infection in microvascular endothelial cells and in ... protein kinase (p38), nuclear factor of activated T cells (NFAT), c-Jun N-terminal kinase/stress- activated protein kinase (JNK/SAPK), and protein kinase C/activator protein-1 (PK...
Ngày tải lên: 18/06/2014, 18:20
... of 9 (page number not for citation purposes) Virology Journal Open Access Research Kaposi's sarcoma associated herpesvirus G-protein coupled receptor activation of cyclooxygenase-2 in vascular ... vGPCR induces COX-2 expression in primary vascular endothelial cells and may be responsible for the COX-2 and PGE 2 increases observed following infection in mi...
Ngày tải lên: 20/06/2014, 01:20
báo cáo sinh học:" A model for integrating strategic planning and competence-based curriculum design in establishing a public health programme: the UNC Charlotte experience" doc
... formation of a School of Nursing, transfer of the Department of Social Work from the College of Arts & Sciences, and a restructuring of the former Department of Health Promotion and Kinesiology into ... guidance in the specification of the curriculum 8. Establish processes for defining, assessing & revising curriculum • Provide structure for the continuing definitio...
Ngày tải lên: 18/06/2014, 17:20
Báo cáo sinh học: " HIV-1 Vpr activates the G2 checkpoint through manipulation of the ubiquitin proteasome system" doc
... character. In contrast, the mutation Q65R, in the leucine-rich domain of Vpr that mediates DCAF1 binding, results in an inactive Vpr devoid of dominant negative behavior. Thus, the interaction of Vpr ... DCAF1 subunit of a cullin 4a/DDB1 E3 ubiquitin ligase. The carboxy- terminal domain Vpr(R80A) mutant, which is able to bind DCAF1, is inactive in checkpoint activation and h...
Ngày tải lên: 18/06/2014, 18:20
Báo cáo sinh học: " Porcine adenovirus type 3 E1Blarge protein downregulates the induction of IL-8" doc
... E1B large protein inhibit the expression of inflamma- tory cytokine IL-8. Luciferase reporter assay Since increased expression of proinflammatory chemok- ines including IL-8, in response to various ... or E1B small + E3 (PAV212). Interestingly, IL-8 transcript was the dom- inant chemokine gene induced in the cells infected with recombinant PAdV-3 containing deletion of E1A + E1B sm...
Ngày tải lên: 18/06/2014, 18:20
Báo cáo sinh học: " Overcoming viral escape with vaccines that generate and display antigen diversity in vivo Albert García-Quintanilla" pot
... the inclusion of multiple strain variants of the same antigen [9]. Here I propose a new kind of vaccines that generate diversity in vivo. Presentation of the hypothesis I hypothesize that priming ... 2005, 23:4647-4657. 8. Locher CP, Heinrichs V, Apt D, Whalen RG: Overcoming anti- genic diversity and improving vaccines using DNA shuffling and screening technologies. Expert Opin Biol...
Ngày tải lên: 18/06/2014, 18:20
Báo cáo sinh học: "High ERCC1 expression predicts cisplatin-based chemotherapy resistance and poor outcome in unresectable squamous cell carcinoma of head and neck in a betel-chewing area" pdf
... were thus defined as having a high expression of ERCC1. As can be seen in Table 1 a summary of result of the ERCC1 immunostaining of the cancer cells and its correlation with the clinicopathologic ... was multiplied by the staining intensity to obtain a final semi-quantitat ive H score. The median value of the H score was chosen as the cutoff point for separating low and high leve...
Ngày tải lên: 18/06/2014, 19:20
Báo cáo sinh học: " Prostate transglutaminase (TGase-4) antagonizes the anti-tumour action of MDA-7/IL-24 in prostate cancer" potx
... staining using Hoescht 33258. Comp.: Double immunofluorescent staining reaction obtained with each of the respective antibodies in B, C and D. Magnification was ×100. Ablin et al. Journal of ... proteins interacting with TGase-4 using immunoprecipitation of proteins from the prostate gland, we i dentified a small panel of proteins that interacted with TGase- 4, including RON (the HG...
Ngày tải lên: 18/06/2014, 19:20
Báo cáo sinh học: "Biobanking after robotic-assisted radical prostatectomy: a quality assessment of providing prostate tissue for RNA studies" doc
... location within a specimen, may influence the quality of RNA obtained [11]. In this paper, we report the methodology of tissue col- lection in our RALP prosta te cancer bioba nk involving 1709 radical ... accumulation of high quality tissue within established biobanks becomes increasingly important. High-throughput cDNA micro- arrays are being used to map gene expression profiles i...
Ngày tải lên: 18/06/2014, 22:20
Báo cáo sinh học: " Science that “knows” and science that “asks” Pierre R Smeesters1*, Marie Deghorain1 and Andrew C Steer2" pdf
... KS: The physician scientist training program in internal medicine at Washington University School of Medicine. Acad Med 2009, 84:468-471. 11. Archer SL: The making of a physician-scientist–the ... do research in the modern health care environment where cost minimisation often drives administrative decision making. After having eaten dry bread during initial years of practice, the cl...
Ngày tải lên: 18/06/2014, 22:20