... character. In contrast, the mutation Q65R, in the leucine-richdomain of Vpr that mediates DCAF1 binding, results in an inactive Vpr devoid of dominant negativebehavior. Thus, the interaction of Vpr ... participation in distinct molecular complexes.The DNA damage recognition of DDB1 involves bindingto certain types of DNA damage, and then recruitment of the NER machinery [26]. This function of DDB1 ... of the ubiquitin/proteasome system (UPS) in the above activity of Vpr.We report that the general function of the UPS is required for Vpr to induce G2 checkpointactivation, as incubation of...