... detected at the dimer interface of the models or in the surroundings of the mutated residues. The models of RNase A covalent dimers in the exchanging conformation were prepared using the 7RSA structure ... at the dimer interface of the models or in the surroundings of the hinge loop residues. Likewise, the models of nonex- changing and exchanging HHP-...
Ngày tải lên: 19/02/2014, 06:20
... undergoes fusion with the membrane of intra-endosomal vesicles contained within MVBs, thereby releasing the nucleocapsid into the lumen of these vesi- cles. Then, the capsid uses these intra-endosomal ... mild developmental delay. The protein defective in this disorder is also a NHEJ protein. The distinct clinical features of the patients will be discussed in the con...
Ngày tải lên: 19/02/2014, 07:20
Tài liệu Báo cáo khoa học: The role of the ESSS protein in the assembly of a functional and stable mammalian mitochondrial complex I (NADH-ubiquinone oxidoreductase) pptx
... proposed X-linkage. Sequence analyses of the ESSS cDNA in these mutants revealed chain termination mutations. In two of these mutants the protein i s truncated at the C-terminus of the targeting sequence; ... likely that the N-terminal domain is involved in protein–protein interactions with other hydrophilic domains of neighboring integral membrane subunits, and inters...
Ngày tải lên: 19/02/2014, 16:20
Tài liệu Báo cáo khoa học: The role of N-glycosylation in the stability, trafficking and GABA-uptake of GABA-transporter 1 Terminal N-glycans facilitate efficient GABA-uptake activity of the GABA transporter pptx
... N-linked oligosaccharide side-chains are important for the GABA transport activity. 1-Deoxymannojirimycin inhibits the GABA-uptake of GAT1 In order to gain further insight into the role of the terminal ... results in reduction of the stability of GAT1 In order to study the in uence of the N-glycosylation and N-linked oligosaccharides on protein stability, the...
Ngày tải lên: 19/02/2014, 17:20
Tài liệu Báo cáo khoa học: The role of the SEA (sea urchin sperm protein, enterokinase and agrin) module in cleavage of membrane-tethered mucins pdf
... frag- ments were then cloned into the SpeI ⁄ XhoI sites of the polylinker in MUC1FDTR. The remaining portions of the polylinker introduced leucine and valine residues N-ter- minal to the MUC3 and ... according to the intensity of M2-reactive species in the corresponding whole cell lysate. Molecular modeling of SEA domain of MUC1 The composer and biopolymer module...
Ngày tải lên: 19/02/2014, 18:20
Tài liệu Báo cáo khoa học: "The Role Of Focussing in Interpretation of Pronouns " pdf
... Processing. Dept. of Computer Science TR-70, Rutgers University, New Brunswick, N.J. Reinhart, T;mya [1976] The Syntactic Domain of Anaphora. unpublished Ph.D. dissertation, Department of Foreign ... and LinBuistics, M.I.T. Rieger, Charles J. [1974] Conceptual Memory: A Theory and Compufer Program for Processing Ihe Meaning Content of Natural Language Utterances. Stanford Arti...
Ngày tải lên: 21/02/2014, 20:20
Tài liệu Báo cáo khoa học: "The Role of Initiative in Tutorial Dialogue" pdf
... using changes in initiative as a starting point; these changes were taken as marking either a segment endpoint or the beginning of a nested segment. tion following a question takes initiative. ... ignoring students' signs of confu- sion. In future work, we will investigate the factors influencing the tutor's decision about whether to entertain a student initiative, a...
Ngày tải lên: 22/02/2014, 02:20
Báo cáo khoa học: The role of evolutionarily conserved hydrophobic contacts in the quaternary structure stability of Escherichia coli serine hydroxymethyltransferase pptx
... at the value determined from the amino acid sequence (45 320 Da). Measurement of the K d of PLP binding equilibrium PLP binding equilibria were analyzed taking advantage of the protein intrinsic ... to explain the increase of the dissociation constant of the monomer–dimer equilibrium determined by the muta- tions. The results obtained in the present study also...
Ngày tải lên: 07/03/2014, 03:20
Báo cáo khoa học: The role of interface framework residues in determining antibody VH ⁄ VL interaction strength and antigen-binding affinity pptx
... antigen in itself [7,20]. At least for these antibodies, the role of the V L domain might be to increase the affinity by supporting the V H domain. The phenomenon may also be observed in the chain ... Although the Fv was designed based on HyHEL-10, it is not clear whether or not H39 is dominantly tuning the V H ⁄ V L interaction of other Fvs, including HyHEL-10. In...
Ngày tải lên: 07/03/2014, 12:20
Báo cáo khoa học: The role of histones in chromatin remodelling during mammalian spermiogenesis pot
... characterized in the mouse [10] as well as in the rat [12]. In situ hybridization detects the RNA in mid-pachytene s permatocytes, a nd immunodetection indi- cates the presence of the p rotein from the ... that in the absence of H1t, H1.1 is o ver-expressed to m aintain the normal ratio of H1 to core histone [22]. Interestingly, the elimination of both H1.1...
Ngày tải lên: 07/03/2014, 16:20