Báo cáo hóa học: " Multiplexed methylation profiles of tumor suppressor genes and clinical outcome in lung cancer" potx

... al.: Multiplexed methylation profiles of tumor suppressor genes and clinical outcome in lung cancer. Journal of Translational Medicine 2010 8:86. Submit your next manuscript to BioMed Central and ... panel of candidate gen es selected could be of clinical relevance for the clinicopathologic staging of human lung tumors. MS-MLPA profiles for clinical...

Ngày tải lên: 18/06/2014, 16:20

... KOOS subscale Pain and the VAS-pain were between r = -0.28 and -0.79. Floor and ceiling effects Neither floor effects (indicating worst possible score) nor ceiling effects (indicating best possible ... subscales Pain, Symptoms and ADL of the KOOS questionnaire. It is plausible that these patients have few complaints of their knee and have no or minor clinical signs of OA, wh...

Ngày tải lên: 18/06/2014, 22:20

... shown that selected sigma-2 ligands are capable of inducing apoptosis in a multitude of human and murine cancer cells lines and in animal models of cancer including pancreas cancer [12,13,15]. The ... representing standard error of the mean. The sigma-2 ligand, SV119, combined with gemcitabine sup-presses tumor growth and increases survival in model pan-creatic adenocarc...

Ngày tải lên: 18/06/2014, 15:20

... carried out and coordinated the study, immunohisto- chemical examinations of tumor specimens and data analysis, and drafted the manuscript. ZYZ and JF partici- pated in the interpretation of data, ... Corresponding author Abstract Background: Tumor Protein p53 (p53), cyclin-dependent kinase inhibitor 1A (p21/WAF1), and murine double minute 2 (MDM2) participate in the re...

Ngày tải lên: 18/06/2014, 15:20

... acquisition of the data, was involved in drafting and revising the manuscript critically for important intellectual content; NB contributed to the analysis and interpretation of data, and was involved in ... statistical analysis and interpretation of data, and drafted the manuscript; ML participated in the design of the study and the statistical analysis and was in...

Ngày tải lên: 18/06/2014, 19:20

... Counting backward (CB) is an attention-demanding task frequently used in dual task paradigm involving gait [4]. Compared with other attention-demanding tasks used in dual-task paradigms involving ... reliability of STV under single and dual-task conditi ons. The objective of this study was to examine immediate test-retest reliability of STV while single and dual tasking in CHI...

Ngày tải lên: 19/06/2014, 08:20

... presence of a dominating five-coordinate high-spin heme coexisting with some six-coordinate high- spin heme. The A 406 /A 280 ratio (i.e. Reinheitszahl) of Asn153fiAla varies between 0.46 and 0.48 ... the cyanide complex and the ferric protein) and the corres- ponding fit are shown in Fig. 4B. The observed rate of cyanide binding to the ferric enzyme linearly increased with the con...

Ngày tải lên: 23/03/2014, 21:20

... treatment for pancreatic cancer patients. The preclinical finding of inhibition of CHK1 as a sensitizing target for gemcitabine is currently being tested in clinical trials. Collectively, the data presented ... targeting checkpoint kinase 1 (CHK1). Validation of the screening results was performed in MIA PaCa-2 and BxPC3 pancreatic cancer cells by examining the dose response of...

Ngày tải lên: 18/06/2014, 15:20

... detection, cells were incubated in PBS with 10 mM glucose containing 5 μM DAF-FM-DA for 30 min at 37°C. After the incubation, cells were washed and incubated in the presence of either: inhibitors, stimu- lators, ... (post intravenous administration of 15 g, 30 g, and 60 g) and time of expo- sure were established. The infusion of 15 g of ascorbic acid in 45 min raised the...

Ngày tải lên: 18/06/2014, 15:20

... cytokines and chemokines and anti HBsAg serum titers in vaccinated healthy donorsFigure 3 Correlation between expression of genes encoding cytokines and chemokines and anti HBsAg serum titers in ... reverse transcribed and amplified in the presence of primers and probes specific for β-actin house keeping gene and genes encoding different cytokines. Expression of...

Ngày tải lên: 18/06/2014, 15:20