cancer—the role of tumor suppressor genes

... Journal of Translational Medicine 2010, 8:86 http://www.translational-medicine.com/content/8/1/86 Page of 11 Table Summary of the frequency of methylation of the genes in lung tumors based of their ... reflect tumor heterogeneity and the polyclonality of the tumors regarding hypermethylation Despite of not containing a lung cancer specific panel of tumor suppressors, we observed correlation of hypermethylation ... panel of candidate genes selected could be appropriate to detect aberrant methylation profiles in human lung tumors MS-MLPA profiles for clinico-histopathologic stratification of lung tumors...

Ngày tải lên: 18/06/2014, 16:20

... down-regulation of UHRF1 by natural compounds is a key event in their mechanism of action, considering that re-expression of tumor suppressor genes in cancer cells is dependent upon demethylation of their ... al.: Down-regulation of UHRF1, associated with re-expression of tumor suppressor genes, is a common feature of natural compounds exhibiting anti-cancer properties Journal of Experimental & Clinical ... decrease the risk of breast Alhosin et al Journal of Experimental & Clinical Cancer Research 2011, 30:41 http://www.jeccr.com/content/30/1/41 Page of 10 Figure Schematic model of the role of UHRF1/DNMT1...

Ngày tải lên: 10/08/2014, 10:21

... Faculty of Medicine I am equally thankful to Prof Hooi Chuan, HOD, Department of Physiology and Prof Barry Halliwell, HOD, Department of Biochemistry In addition, I am also thankful to Prof Soo ... localization of p73 1.3.2 Gene architecture of p73 IV 1.3.3 Structural organization of p73 promoter 1.3.4 Structure organization of p73 1.3.5 Expression of p73 1.3.5.1 Expression of p73 in normal ... pattern of loss of hetrozygocity in the remaining allele of p73 gene (Melino et al., 2002) 1.3.2 Gene architecture of p73 The structure of the p73 gene is highly complex when compared to that of p53...

Ngày tải lên: 16/09/2015, 15:55

... a variety of other pulmonary lesions especially metastatic lesions to the lung In women, the appearance of metasta- http://www.wjso.com/content/6/1/7 sis is a frequent complication of breast ... strong indicator of malignant lung nodules, is a reliable diagnostic test that can avert needle biopsy of lesions that not show significant metabolic activity During the evaluation of the malignancies ... characterizing indetermi- Page of (page number not for citation purposes) World Journal of Surgical Oncology 2008, 6:7 http://www.wjso.com/content/6/1/7 FDG PET scans, First Column of the Figure showed...

Ngày tải lên: 09/08/2014, 07:21

... inflammation [15] The induction of lupus-like disease by TNF blockers appears to be quite uncommon, with an incidence of 0.5% to 1% [20,25,35], and independent of the type of TNF-blocking drug [32,36] ... disease of moth-eaten mice [18] and nephritis and leukopenia in the C3H.SW mouse [19], two additional lupus models Of particular interest, administration of low-dose TNF later in the course of NZB/W ... dual role beneficial and detrimental Page of (page number not for citation purposes) Nevertheless, seven cases of nephritis occurring under antiTNF therapy have been reported [37-39] Four of these...

Ngày tải lên: 09/08/2014, 10:22

... Inactivation of Tumor Suppression Genes Cancer may also be caused by the inactivation of tumor suppressor genes Tumor suppressor genes refer to genes whose loss of function results in the promotion of ... understanding of the mechanisms underlying DNA methylation of tumor suppressor genes is extremely important for unraveling the possible roles of tumor suppressor genes in the progression from normal to tumor ... allele of a tumor suppressor gene in solid tumors, LOH in a particular chromosomal region in a tumor may indicate the presence of a tumor suppressor gene that contributes to the tumor In HCC, tumor...

Ngày tải lên: 11/09/2015, 16:07

... silencing of tumor suppressor genes is achieved by different mechanisms, such as DNA methylation and histone modification These observations suggest that Page of 14 additional tumor suppressor genes ... discovered for specific tumor types Many genes identified in our study are either known tumor suppressor genes (for example, BRCA1) or previously identified putative tumor suppressor genes (for example, ... between LOH and tumor susceptibility is significant only when several tumor suppressor genes are involved in the LOH events [10,33] Second, in addition to common tumor suppressor genes shared by...

Ngày tải lên: 09/08/2014, 22:23

... abnormalities found in cancer typically affect two general classes of genes: oncogenes and tumor suppressor genes (TSG) Alteration of these genes are responsible for self-sufficiency in growth signals ... deletion of multiple chromosomal regions including chromosomes 5q, 17p, and 18q Such chromosome loss is often suggestive of the deletion or loss of function of TSGs The candidate tumor suppressor genes ... epigenetic activation of oncogenes) and localized aberrant hypermethylation of CpG islands, resulting in transcriptional repression of many important genes, including tumor suppressor genes (Ting et...

Ngày tải lên: 16/10/2015, 15:37

... GH, Piao WH, He Y, Zhang HH, Wang GQ, Piao Z Hyper-methylation of RIZ1 tumor suppressor gene is involved in the early tumorigenesis of hepatocellular carcinoma Histol Histopathol 2008; 23: 1171-5 ... cancers of the RIZ1 tumor suppressor gene, a member of a histone/protein methyltransferase superfamily Cancer Res 2001; 61: 8094-9 Jiang GL, Huang S Adenovirus expressing RIZ1 in tumor suppressor ... IV of eight types of cancer (stage III in prostate cancer), indicating that RIZ1 might play an important role in tumor metastasis in late disease stages in addition to the previously reported tumor...

Ngày tải lên: 25/10/2012, 11:15

... 17.6 The role of cancer registries in cancer control The cancer registry is an essential part of any rational programme of cancer control Its data can be used in a wide variety of areas of cancer ... be of reduced benefit in the control of these cancers in Thailand compared with the potential benefits of primary and secondary prevention (e.g., control 400 The role of cancer registries of ... representativeness of the case series 394 The role of cancer registries The registry may, however, carry out its own case–control studies using its database, comparing one type of cancer with a selection of...

Ngày tải lên: 15/02/2014, 04:20

... models [19] To obtain more insight into the role of the fat breast tissue, we investigated the independent effects of the size of dense tissue and the size of non-dense tissue in the breast and their ... Currently, two studies have investigated the role of the breast fat tissue with different results Stone et al investigated the role of the non-dense area in a group of women in the United Kingdom comparable ... estimate of dense and non-dense tissue volume in the coming years Conclusions We observed that besides the size of dense tissue, the size of non-dense tissue also plays a role in the development of...

Ngày tải lên: 22/03/2014, 17:20

... the downstream genes of NF-κB CIAP-2 and survivin are members of the anti-apoptotic IAP (Inhibitors of Apoptosis) family of proteins suppressing apoptosis and their expression in tumors has been ... inactivation of NF-κB signaling, resulting in the inhibition of cell proliferation and induction of apoptosis (Figure 5) Our hypothesis is also supported by the evidence of down-regulation of the important ... however the role of genistein in chemo-resistant ovarian cancer cells has not been investigated Therefore, the intent of this study was to evaluate the effect of genistein for sensitization of ovarian...

Ngày tải lên: 20/06/2014, 07:20

... linkage analysis of 14 candidate genes in OA kindreds resulted in the exclusion of 10 important cartilage genes, including COL2A1 [40] Analysis of 47 families with the phenotype of earlyonset primary ... fibrils The presence of thick fibrils, providing direct evidence of a role of type XI collagen in regulating fibril diameters, leads to the formation of a large-pore network of fewer fibrils in ... a better understanding of the pathogenesis of OA as well as a basis for developing earlier preventive strategies and providing targets for the development of new forms of treatment Acknowledgements...

Ngày tải lên: 09/08/2014, 06:22

... regardless of the status of their liver metastasis However, the number of patients who received resection of the primary tumor despite stage III liver metastasis is small and the role of postoperative ... resection of the primary and metastatic liver tumors, the reported rate of pelvic failure was approximately 30-35% and the rate of extra-hepatic metastases was up to 67% [9,10] The cause of death ... patient whose metastatic hepatic tumor was determined to be resectable based on location of tumor, extent of disease, and adequate hepatic function For metastatic tumors smaller than cm in diameter,...

Ngày tải lên: 09/08/2014, 09:20

... 1,25-(OH) 2D3 plays a role in B cell homeostasis by the inhibition of proliferation and induction of apoptosis of activated B cells [48] 1,25-(OH)2D3 inhibits the differentiation of B lymphocytes ... for a protective role of VitD in the development of RTI but high quality randomized clinical trials within a sufficiently high number of patients and for a sufficient period of time are missing ... 2Department of Internal Medicine, Division of Endocrinology & Diabetology, Department of Internal Medicine, University Hospital Marburg, 35043 Marburg, Germany Department of Pulmonology, University of...

Ngày tải lên: 12/08/2014, 13:22

... polymerase genes (PB2, PB1, PA) of the 1918 A/ H1N1 virus were of avian origin, since they are outside of the spectrum of the A/H1N1 folding energies and in the lower spectrum of folding energies of ... that the polymerase genes of the 1918 virus were of avian origin [6] In agreement with this hypothesis, we found that the folding energies of the polymerase genes (segments 1-3) of the 1918 strain ... RNA folding free energies in the lowest part of the human spectrum (Figure 1) is indicative of the importance of the NA and HA genes in the success of replication and host adaptation [29] Volume...

Ngày tải lên: 14/08/2014, 21:20

... apoptosis Many of these processes are hallmarks of cancer and NF-κB has been hypothesised to have a role in tumorigenesis The aim of the current study was to investigate the role of both NF-κB ... The role of IKKalpha, IKKbeta and NF-kappaB in the progression of breast cancer Lindsay Bennett BSc(Hons), MSc Submitted in fulfillment of the requirements for the degree of PhD Institute of Cancer ... expression of proliferation- and/or HER2-related genes and lower expression of ER-related genes The HER2-enriched group accounts for 15-20% of breast cancers These tumours exhibit high expression of...

Ngày tải lên: 22/12/2014, 21:49

... postulated that the resulting defects in the biogenesis of lysosomal related organelles, of which Rab38 is believed to play a role, gives rise to some of the symptoms observed in HPS, including albinism ... Tumourigenesis of neuroendocrine tumours [66] There are a number of other Rabs for which changed expression levels are associated with various types of cancers, although their mechanism of action ... view of the oncogenic potency of MUC1, it does appear that if Rab31 could effectively elevate and sustain functional levels of MUC1-C, it could help drive oncogenesis Rab31’s modulation of EGFR...

Ngày tải lên: 22/09/2015, 15:17

... proliferation A frequent mechanism of evading growth suppressors is the mutation of suppressor genes Retinoblastoma (RB) and tumor protein 53 (p53) are two key suppressor proteins that act as central ... sensitivity of MCF-7 in soft agar 73 X     Figure 3.8 Forced expression of TFF3 reduced docetaxel sensitivity of MCF-7 cells in a BCL-2-dependent manner in soft agar 75 Figure 3.9 Forced expression of ... lines 84 IX     LIST OF FIGURES Figure 1.1 Therapeutic targeting of the hallmarkers of cancer Figure 1.1 Therapeutic targeting of the hallmarks of cancer Figure 1.2 Anatomy of the normal female...

Ngày tải lên: 02/10/2015, 17:15

... Table of contents Table of contents Acknowledgements i Table of Contents ii-iv Summary v-vi List of Tables vii List of Figures viii-x List of Common Abbreviations xi-xii Introduction The use of ... the study of gene function can also be extended to the study of oncogenes and tumour suppressors Through the use of tissue-specific promoters, one can control the expression of oncogenes or mutant ... ELUCIDATING THE ROLE OF AUTOPHAGY IN ZEBRAFISH MODELS OF LIVER CANCER SIM HUEY FEN, TINA (B.Sc.(Hons.)), NUS A THESIS SUBMITTED FOR THE DEGREE OF MASTER OF SCIENCE DEPARTMENT OF BIOLOGICAL SCIENCES...

Ngày tải lên: 12/10/2015, 17:35