Báo cáo hóa học: " Phase I clinical trial of the vaccination for the patients with metastatic melanoma using gp100derived epitope peptide " pot

... as described above. Percent inhibition was determined using the following formula: [(% specific lysis of inhibi- tion by isot ype control) - (% specific lysis of inhibition by MAb)]/(% specific lysis ... clinical trial of the vaccination for the patients with metastatic melanoma using gp100- derived epitope peptide restricted to HLA-A*2402 Toshiyuki Baba 1†...

Ngày tải lên: 18/06/2014, 16:20

... chosen for further clinical eval- uation because the toxicity increased with higher doses in the prior phase I/ II clinical trials, whereas there was evi- dence of reproducible immune activation ... the administration of equivalent mixtures of antibody and IL2 [6]. EMD 273063 was tested in a phase I clinical trial aimed at evaluating its safety, toxicity and in...

Ngày tải lên: 18/06/2014, 15:20

... mutations in RCC patients provided the potential for developing a novel targeted vaccine for RCC. In this pilot study, we tested the feasibility of vaccinating advanced RCC patients with the corresponding ... prognosis [21,22]. In addition, we and others have demonstrated in previous clinical trials that vaccination with peptides from different cancers pro- duces speci...

Ngày tải lên: 18/06/2014, 16:20

... recruited from a local fitness center. Inclusion criteria for the patients were: i) a stroke with a Motricity Index score of the paretic leg <100; i i) time since stroke: ≥ 1 month; iii) ability ... metric for assessing the bilat- eral coordination of gait (PCI) have the potential to enhance the quantitative monitoring of symptoms and the setting of rehabilit...

Ngày tải lên: 19/06/2014, 08:20

... time assistive (it f acilitates the acquisition of the target) and in formative (it lets the subject know, in real-time, where the target is also in the absence of vision). For slightly impaired ... possibility, for the studied population of patients, because they immediately adapted to the experimental setup in the initial familiarization phase and answered in a...

Ngày tải lên: 19/06/2014, 08:20

... progressive disease (Fig. 4B, p = 0.0206). Discussion This study established the safety and feasibility of com- bining vaccination with MVA expressing 5T4 and high- dose IL-2 in patients with metastatic ... regulatory ratio in future clinical trials. In summary, this study provides safety and feasibility data supporting the combination of MVA-5T4 vaccine and IL- 2 for p...

Ngày tải lên: 18/06/2014, 15:20

... could be clinically useful; however, the utility of the evaluation of HMGB1 over-expression in tissue is somewhat limited because of the relatively higher-risk, invasiveness and high cost of the procedures ... 0.05). The HMGB1 level was significantly cor- related with stage by UICC-TNM classification except for stage IV. Evaluation of the sensitivity and specificity...

Ngày tải lên: 18/06/2014, 15:20

... to Paclitaxel in Type I EOC cells. This suggests the impor- tance of identifying the molecular phenotype of the tumor prior to the initiation of therapy. Conclusion Administration of Paclitaxel to patients ... patients. ARRY-520 is an inhibitor of the mitotic kinesin, KSP. KSP inhibition prevents bipolar spindle formation leading to mitotic arrest and cell death [6]....

Ngày tải lên: 18/06/2014, 15:20

... L2-neutralizing epitope was inserted on the surfaces of VLPs increasing the titers of neutralizing antibodies approximately 10-fold [60]. A synthetic L2 lipopeptide, in which the cross-neu- tralizing ... capable of mimicking the natural virus and eliciting high-titers of virus neutra- lizing antibodies. The L1 gene from the viral genome was sub-cloned in microorganisms,...

Ngày tải lên: 18/06/2014, 16:20

... activin receptor type I. In the absence of the carbohydrate moiety, activin receptor type I- mediated signaling of BMP-6 is totally diminished. Thus, flexibility within the binding epitope of BMP-6 and ... inactive in these cells, probably due to its lack of binding to ActR -I. (B) Signaling of BMP-6 and BMP-7 via ActR -I is shown in the inhibition of proliferation in...

Ngày tải lên: 23/03/2014, 07:20