... membrane proteins are seg- regated into separate transport vesicles within the TGN by virtue of sorting signals within the protein [13]. Spe- cifically, the apical targeting of proteins within MDCK cells ... to be enriched mainly in neutral glycos- phingolipids and sphingomyelin, whereas phosphati- dylcholine is concentrated in the basolateral domain (for a discussion, see [24–26]). In...
Ngày tải lên: 16/03/2014, 04:20
... Donghui Feng, Erin Shaw, and Eduard Hovya. 2006a. Mining and assessing discussions on the web through speech act analysis. In Proceedings of the Workshop on Web Content Mining with Human Language ... 5th International Semantic Web Conference. Jihie Kim, Erin Shaw, Donghui Feng, Carole Beal, and Eduard Hovy. 2006b. Modeling and assessing student activities in on-line discussions. In Pr...
Ngày tải lên: 08/03/2014, 03:20
Báo cáo Y học: Rapid caspase-dependent cell death in cultured human breast cancer cells induced by the polyamine analogue N1,N11-diethylnorspermine pdf
... polyamine a nalogues are presently undergoing Phase I and Phase II clinical evaluations in the US. In L56Br-C1 cells, DENSPM treatment induced an increase in SSAT activity, which resulted in a ... DENSPM-induced increase in SSAT activity was not as extensive as in any of those t wo cell lines. The depletion of the polyamine pools was however, similar in all three cell lines. T...
Ngày tải lên: 17/03/2014, 23:20
Báo cáo khoa học: The specific delivery of proteins to human liver cells by engineered bio-nanocapsules doc
... proteins for the C-terminal moiety of the L fusion proteins, depending on the character of the proteins to be fused. This possibility will include cytoplasmic proteins, as well as cytokines or ... proteinase K was extre- mely useful in studying the C-terminal topology of L fusion protein. Proteinase K treatment of the L(D32)-FLAG–EGFP particles showed results similar to those obtained ... p...
Ngày tải lên: 23/03/2014, 15:20
Báo cáo khoa học: Truncated P-cadherin is produced in oral squamous cell carcinoma docx
... identified. Cadherin subfamilies can be divided into type I cadherins (classical cadherins containing an HAV amino acid sequence in EC1) and type II cadherins. Type I and type II cadherins are characterized ... extracellular cadherin repeats, EC1–EC5; intracellularly, they are linked to the actin cytoskeleton [4]. During embryonic development, cadherins control diverse morphogenetic proc...
Ngày tải lên: 30/03/2014, 04:20
Tài liệu Báo cáo khoa học: Type I antifreeze proteins expressed in snailfish skin are identical to their plasma counterparts doc
... the protein contains kinks or bends in the backbone around the helix-breaking proline residues. Based on protein primary structure, most type I AFPs cluster into three distinct groups, depending on ... solution freezing point noncolligatively by binding to certain surfaces of ice crystals, modifying their structure and inhibiting further growth. The difference between the lowered freezing p...
Ngày tải lên: 20/02/2014, 02:22
Tài liệu Báo cáo khoa học: "Which words are hard to recognize? Prosodic, lexical, and disfluency factors that increase ASR error rates" ppt
... al- ready incorporates speaker adaptation models. 5 Conclusion In this paper, we introduced the individual word er- ror rate (IWER) for measuring ASR performance on individual words, including insertions ... the intercept). Full model contains all predictors; Reduced contains only predictors contributing significantly to fit; Baseline contains only intercept. Other models are ob- tained by...
Ngày tải lên: 20/02/2014, 09:20
Tài liệu Báo cáo Y học: Short peptides are not reliable models of thermodynamic and kinetic properties of the N-terminal metal binding site in serum albumin doc
... 2002 Short peptides are not reliable models of thermodynamic and kinetic properties of the N-terminal metal binding site in serum albumin Magdalena Sokolowska 1 , Artur Krezel 1 , Marcin Dyba 1 , Zbigniew ... modelling of Cu(II) and Ni(II) transport by albumins. Keywords: serum albumin; copper(II); nickel(II); binding constants; rate constants. Human s erum albumin (HSA) is t he most ab...
Ngày tải lên: 22/02/2014, 04:20
Tài liệu Báo cáo Y học: Transactivation domains are not functionally conserved between vertebrate and invertebrate serum response factors potx
... as those of the human cardiac a-actin gene or an A. franciscana actin 403 promoter where the SRF-binding site has been mutated. Mapping of A. franciscana SRF domains involved in transcriptional activation ... [10,11]. SRF binding sites found in the promoter of serum-induced and muscle-specific genes are very similar and contain consensus CArG boxes: CC(A/T) 6 GG [12]. Despite the simil...
Ngày tải lên: 22/02/2014, 07:20
Báo cáo khoa học: Many fructosamine 3-kinase homologues in bacteria are ribulosamine⁄erythrulosamine 3-kinases potentially involved in protein deglycation docx
... & Van Schaftingen E (2003) A mammalian protein homo- logous to fructosamine-3-kinase is a ketosamine-3- kinase acting on psicosamines and ribulosamines but not on fructosamines. Diabetes 12, ... compounds, including ribulose- lysine and erythruloselysine. It was also inactive on more than 50 other potential phosphate acceptors, including d-ribulose, d-xylulose, choline, ethanol- amine, l-...
Ngày tải lên: 07/03/2014, 05:20