báo cáo hóa học:" Let-7 microRNAs are developmentally regulated in circulating human erythroid cells" docx

Báo cáo khoa học: Complex gangliosides are apically sorted in polarized MDCK cells and internalized by clathrin-independent endocytosis doc

... membrane proteins are seg-regated into separate transport vesicles within the TGNby virtue of sorting signals within the protein [13]. Spe-ciﬁcally, the apical targeting of proteins within MDCKcells ... to be enriched mainly in neutral glycos-phingolipids and sphingomyelin, whereas phosphati-dylcholine is concentrated in the basolateral domain(for a discussion, see [24–26]). In this study, ... Consequently, the internal-ization of these domains may well play an importantrole in signalling events.GD3 and GM1 internalization and trafﬁcking in MDCK cell lines were monitored using a speciﬁc...

Báo cáo khoa học: "Automatically Assessing the Post Quality in Online Discussions on Software" docx

... Donghui Feng, Erin Shaw, and EduardHovya. 2006a. Mining and assessing discussions on the webthrough speech act analysis. In Proceedings of the Workshopon Web Content Mining with Human Language ... 5th International Semantic Web Conference.Jihie Kim, Erin Shaw, Donghui Feng, Carole Beal, and EduardHovy. 2006b. Modeling and assessing student activities in on-line discussions. In Proceedings ... moderation in a large online conversation space. In Proceedings of ACM CHI 2004 Conference on Human Factors in Computing Systems, Vienna Austria, pages 543–550.Mitchell P. Marcus, Beatrice Santorini,...

Báo cáo Y học: Rapid caspase-dependent cell death in cultured human breast cancer cells induced by the polyamine analogue N1,N11-diethylnorspermine pdf

... polyamine a nalogues are presently undergoing Phase I and Phase II clinicalevaluations in the US. In L56Br-C1 cells, DENSPM treatment induced anincrease in SSAT activity, which resulted in a ... DENSPM-induced increase in SSAT activity wasnot as extensive as in any of those t wo cell lines. Thedepletion of the polyamine pools was however, similar in allthree cell lines. The differences in ... nonfunctional [18].The cell line was maintained in serial passages in RPMI1640 medium supplemented with 10% heat-inactivated fetalbovine serum, 1 0 lgÆmL)1insulin, 2 0 ngÆmL)1epidermalgrowth...

Báo cáo khoa học: The speciﬁc delivery of proteins to human liver cells by engineered bio-nanocapsules doc

... proteinsfor the C-terminal moiety of the L fusion proteins,depending on the character of the proteins to be fused.This possibility will include cytoplasmic proteins, aswell as cytokines or ... proteinase K was extre-mely useful in studying the C-terminal topology ofL fusion protein. Proteinase K treatment of theL(D32)-FLAG–EGFP particles showed results similarto those obtained ... particles. The greatest problem in using theparticle is that people who have antibodies to HBV are increasing in number due to the widespread hepati-tis B vaccination program. Stealth mutations...

Báo cáo khoa học: Truncated P-cadherin is produced in oral squamous cell carcinoma docx

... identiﬁed. Cadherin subfamiliescan be divided into type I cadherins (classical cadherinscontaining an HAV amino acid sequence in EC1) andtype II cadherins. Type I and type II cadherins are characterized ... extracellularcadherin repeats, EC1–EC5; intracellularly, they are linked to the actin cytoskeleton [4]. During embryonicdevelopment, cadherins control diverse morphogeneticprocesses determining tissue ... of theirinvasive capability in vitro [14,15], and activation ofE-cadherin expression results in growth inhibition oftumor cell lines [16]. Also, T-cadherin (cadherin-13 ⁄ H-cadherin), a special...

Tài liệu Báo cáo khoa học: Type I antifreeze proteins expressed in snailﬁsh skin are identical to their plasma counterparts doc

... theprotein contains kinks or bends in the backbonearound the helix-breaking proline residues.Based on protein primary structure, most type IAFPs cluster into three distinct groups, dependingon ... solutionfreezing point noncolligatively by binding to certainsurfaces of ice crystals, modifying their structure andinhibiting further growth. The difference between thelowered freezing point and ... antifreeze proteins (AFPs) are usually small, Ala-rich a-helical poly-peptides found in right-eyed ﬂounders and certain species of sculpin. Theseproteins are divided into two distinct subclasses,...

Tài liệu Báo cáo khoa học: "Which words are hard to recognize? Prosodic, lexical, and disﬂuency factors that increase ASR error rates" ppt

... al-ready incorporates speaker adaptation models.5 Conclusion In this paper, we introduced the individual word er-ror rate (IWER) for measuring ASR performanceon individual words, including insertions ... theintercept). Full model contains all predictors; Reducedcontains only predictors contributing signiﬁcantly to ﬁt;Baseline contains only intercept. Other models are ob-tained by removing features from ... to otherASR systems in order to determine the generalityof our ﬁndings, we have already gained importantinsights into a number of factors that increase ASRerror rates. In addition, our results...

Tài liệu Báo cáo Y học: Short peptides are not reliable models of thermodynamic and kinetic properties of the N-terminal metal binding site in serum albumin doc

... 2002Short peptides are not reliable models of thermodynamicand kinetic properties of the N-terminal metal binding site in serum albuminMagdalena Sokolowska1, Artur Krezel1, Marcin Dyba1, Zbigniew ... modelling ofCu(II) and Ni(II) transport by albumins.Keywords: serum albumin; copper(II); nickel(II); bindingconstants; rate constants. Human s erum albumin (HSA) is t he most abundant proteinof ... The kinetics of metal bindingto peptides and their exchange was studied in 100 mMTris/HCl and in 100 mMphosphate buffers, both atpH 7.4.UV–Vis spectroscopyThe kinetics of Ni(II) binding...

Tài liệu Báo cáo Y học: Transactivation domains are not functionally conserved between vertebrate and invertebrate serum response factors potx

... as those of the human cardiaca-actin gene or an A. franciscana actin 403 promoter wherethe SRF-binding site has been mutated. Mapping ofA. franciscana SRF domains involved in transcriptionalactivation ... [10,11].SRF binding sites found in the promoter of serum-inducedand muscle-speciﬁc genes are very similar and containconsensus CArG boxes: CC(A/T)6GG [12]. Despite thesimilarity in their SRF-binding ... deleted proteins (N1 to N7 and C1) with reporter vectors containing human cardiac a-actin (CA) or Actin 403 mutated (Act403 mut) promoters in Bsc1 cells. Samples C show the activity obtained without...

Báo cáo khoa học: Many fructosamine 3-kinase homologues in bacteria are ribulosamine⁄erythrulosamine 3-kinases potentially involved in protein deglycation docx

... &Van Schaftingen E (2003) A mammalian protein homo-logous to fructosamine-3-kinase is a ketosamine-3-kinase acting on psicosamines and ribulosamines butnot on fructosamines. Diabetes 12, ... compounds, including ribulose-lysine and erythruloselysine. It was also inactive onmore than 50 other potential phosphate acceptors,including d-ribulose, d-xylulose, choline, ethanol-amine, l-serine, ... theEscherichiacoliFN3KPFKbOuterMembraneProteinHypotheticalproteinHydrolaseYniCYniBThermusthermophilusFN3KLMW-PTPHistidinekinaseIndAproteinHypotheticalproteinGTPbindingproteinCytophagahutchinsoniiFN3KLMW-PTPFe uptakeregulatorAlkylhydroperoxidereductaseHypotheticalproteinsFig....

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