báo cáo hóa học:"Interdependency of CEACAM-1, -3, -6, and -8 induced human neutrophil adhesion to endothelial cells" pdf

... purposes) Journal of Translational Medicine Open Access Research Interdependency of CEACAM-1, -3, -6, and -8 induced human neutrophil adhesion to endothelial cells Keith M Skubitz* 1 and Amy PN Skubitz 2 Address: ... on neutrophil adhesion to endothelial cells Because CEACAM-1, -3, -6, and -8 are highly homologous structurally, and...

Ngày tải lên: 18/06/2014, 15:20

... of Ab-01 and Ab- 02 to cynomolgus monkey IL-21R are similar to the respective values for human IL-21R. To support preclini- cal development of Ab-01 and Ab-02, pharmacokinetic (PK) profiles of ... the treatment of a variety of autoimmune diseases. Ab-01 and Ab-02 are human neutralizing anti-IL-21R antibodies generated by phage display technology. Ab-01 and Ab-02 bi...

Ngày tải lên: 18/06/2014, 16:20

... expansion of these cells, which lacking CCR7 expression have the capacity to migrate to inflam- mation sites and to produce large amounts of proin- flammatory cytokines, may be one of the r easons of ... EA: Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoprolifera...

Ngày tải lên: 18/06/2014, 16:20

... Abstract Background: The mode of questionnaire administration may affect the estimates and applicability of oral health-related quality of life indicators. The aim of this study was to compare psychometrically ... Medical Ethics Committee, the Research and Development Panel of the Bedfordshire Heartlands Primary Care Trust and the Research and Development Directorate of...

Ngày tải lên: 18/06/2014, 22:20

... 5177 store-operated channels and IP3 receptors with 2-APB (Fig. 6A). In the absence of extracellular calcium or in the presence of both calcium and 2-APB, the weak responses of copines-3 and -6 to ... 238–248. 15 Cowland JB, Carter D, Bjerregaard MD, Johnsen AH, Borregaard N & Lollike K (2003) Tissue expression of copines and isolation of copines I and III from the c...

Ngày tải lên: 29/03/2014, 21:20

... [18]. Both GSK3b and p53 have been shown to localize to mitochondria. GSK3b was localized to the mito- chondria of cerebellar cells [19] and enrichment of act- ive GSK3b in mitochondria and nuclei ... increase expression of the mitochondrial biogenesis markers. However, mRNA levels of the nuclear genes ATP syn- thase-b, cytochrome oxidase VIc and TFAM, and of the mit...

Ngày tải lên: 23/03/2014, 09:20

... Prm3b ()975 to +1), Prm3a ()404 to +1), Prm3ab ()320 to +1), Prm3aa ()154 to +1), Prm3aab ()106 to +1) and 3aaa ()50 to +1) were subcloned into pGL3Basic (A and C) or pGL3Enhancer (B and D). Resulting ... between )154 to )106 and )50 to +1, were identified within the core Prm3. Deletion and site-directed mutagenesis of consensus Oct-1 ⁄ 2 and AP-1 elements within...

Ngày tải lên: 19/02/2014, 16:20

... in normal and cataractous human lenses. Exp. Eye Res. 25, 139–148. 59. Garner, M.H. & Spector, A. (1980) Selective oxidation of cysteine and methionine in normal and senile cataractous lenses. ... inactivation of GAPDH and GR occurs via oxidation of nonactive site residues, that bring about loss of functional integrity, the stoichiometry of inactivation ( i.e. the loss...

Ngày tải lên: 21/02/2014, 03:20

... facilitate the docking of the precursor proteins of the mitochondrial P i and the ADP/ATP carriers on the Tom70–Tom37 complex, an import receptor localized on the outer mitochondrial membrane. ... yeast mitochondria, the protein was found to be fully functional and to be regulated by FFAs and nucleotides, s imilarly to when expressed i n i ts native location, the mitochondria...

Ngày tải lên: 21/02/2014, 15:20

... of apoptosis in B cells. Scan.J.Immunol. 43, 406–412. 28. Tortorella, C., Piazzolla, G., Spaccavento, F. & Antonaci, S. (1998) Effects of granulocyte-macrophage colony-stimulating factor and ... Biology, Institute of Biological and Life Sciences, University of Glasgow, Scotland; 5 Department of Molecular Biology, Institute of Biotechnology, Flanders Interuniversity, Univers...

Ngày tải lên: 17/03/2014, 09:20