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báo cáo hóa học:" More insights into the immunosuppressive potential of tumor exosomes" pptx

báo cáo hóa học:

báo cáo hóa học:" More insights into the immunosuppressive potential of tumor exosomes" pptx

... 2004:9683-9688.BioMed CentralPage 1 of 4(page number not for citation purposes)Journal of Translational MedicineOpen AccessEditorial More insights into the immunosuppressive potential of tumor exosomesVeronica ... through the expression of HLA/peptidecomplexes [6]. Based on these and following observationsabout the role of exosomes in antigen presentation, the exacerbated production of these vesicles by tumor ... scientistresponsible for the studies on the immunosuppressive functions of tumor exosomes. PF was responsible foreditorial reviewing, scientist responsible for the studies on the induction of myeloid-derived...
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Tài liệu Báo cáo khoa học: Structural insights into the substrate specificity and activity of ervatamins, the papain-like cysteine proteases from a tropical plant, Ervatamia coronaria ppt

Tài liệu Báo cáo khoa học: Structural insights into the substrate specificity and activity of ervatamins, the papain-like cysteine proteases from a tropical plant, Ervatamia coronaria ppt

... proton from the catalytic Cys pres-ent at the N-terminus of the helix to the His of the dyad [19,50,51]. The first stage of catalysis is mediatedby the highly active thiolate ion of the Cys. Biochemi-cal ... at the bottom of the subsite is conservedin ervatamins. Compared to a Ser in the equivalentposition of papain, the role of Leu here is to restrict the size and depth of the S2 subsite. The ... erva-tamin-A, the P3 moiety of both the molecules of the asymmetric unit runs along the extended backbone of residues 65–64 and is partly exposed to the solvent(Fig. 2B). On the other hand, the P3...
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Tài liệu Báo cáo khóa học: Further insights into the assembly of the yeast cytochrome bc1 complex based on analysis of single and double deletion mutants lacking supernumerary subunits and cytochrome b pdf

Tài liệu Báo cáo khóa học: Further insights into the assembly of the yeast cytochrome bc1 complex based on analysis of single and double deletion mutants lacking supernumerary subunits and cytochrome b pdf

... antibodies to the subunits of the yeast bc1complex indicated on the left side of the blots.1212 V. Zara et al. (Eur. J. Biochem. 271) Ó FEBS 2004Further insights into the assembly of the yeast ... encoded in the nucleus, synthesized by cytosolicpolysomes, and then imported into mitochondria, therebyreaching their final location in the inner membrane [17]. The similarities of the yeast ... relatively unaffected. Therefore, the absence of subunit 6 appeared to alter the rates of processing of two of the redox subunits and caused minor changes in amounts of the small supernumerary...
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Báo cáo khoa học: New insights into the functions and N-glycan structures of factor X activator from Russell’s viper venom pot

Báo cáo khoa học: New insights into the functions and N-glycan structures of factor X activator from Russell’s viper venom pot

... sequenced. Of these, 10clones were found to encode the LC2 and LC1 sub-units. Others were found to encode other variants of the C-lectin-like venom proteins. The amino acidsequences of both subunits ... endothelial cells. The important role of theseglycans in pharmacokinetics has been demonstrated by the slower and smaller increment of FDP in vivo after the injection of desialylated RVV-X rather ... systemic haemorrhage in mice.These results emphasize the importance of the rapidhoming of RVV-X into microvessels to exert its effect. The glycan structures of a number of venom glycopro-teins...
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Báo cáo khoa học: New insights into the P-glycoprotein-mediated effluxes of rhodamines doc

Báo cáo khoa học: New insights into the P-glycoprotein-mediated effluxes of rhodamines doc

... the cytosol. This observation allows the further determination of the concentration of drug free in the cytosol of resistantcells. The determination of karequires also the measurement of the ... the rate of passive diffusion of the dye through the plasma membrane. This cannot be done by the simplemeasurement of the increase of the fluorescence signal(Fcyto) of the cells when they are ... concentration, the rate of their passive diffusionthrough the plasma membrane and then the kineticparameters characteristic of their P-gp-mediated efflux.Our data show that the efficiencies of the P-gp-mediatedefflux...
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Báo cáo khoa học: New insights into structure–function relationships of oxalyl CoA decarboxylase fromEscherichia coli pptx

Báo cáo khoa học: New insights into structure–function relationships of oxalyl CoA decarboxylase fromEscherichia coli pptx

... molecules of the cofactor ThDP are bound in the canonical V conformation at the interface between the PYR domain and the PP domain of two subunits of the functional dimer. The main chain oxygen of G421 ... The mainchain nitrogens of residues I322 and I303 interact withnitrogen atoms of the adenine ring and the c-carboxylgroup of the side chain of residue D302, the d and xnitrogen atoms of the ... wasfound for the S-acetyl pantetheine part of acetyl CoA,and consequently the model for the inhibitor remainsincomplete. The nitrogen atom of the amino group of the adenosine ring of PADP interacts...
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Báo cáo khoa học: Recent insights into cerebral cavernous malformations: the molecular genetics of CCM pot

Báo cáo khoa học: Recent insights into cerebral cavernous malformations: the molecular genetics of CCM pot

... com-plete loss of any of the three CCM proteins within endothelial cells lining the cavernous capillary cavities. These data were an important step towards the elucidation of the mechanisms of this ... PDCD10. The expression of the mRNAin lymphoblastoid cell lines of the patient was shownto be significantly decreased suggesting that the inter-ruption of this gene may be causal. However, the sameauthors ... and future The recent identification of the three CCM genes is animportant step towards the elucidation of the mecha-nisms of this condition. It helped to clarify several fea-tures of this condition...
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Báo cáo khoa học: Recent insights into cerebral cavernous malformations: animal models of CCM and the human phenotype pptx

Báo cáo khoa học: Recent insights into cerebral cavernous malformations: animal models of CCM and the human phenotype pptx

... exhibit the same pheno-type as the heg mutant fish – that of the dilated heartcovered by a single layer of myocardium. The similar-ity of the phenotype in these nonsense alleles suggestedthat these ... to the endothelium, with a primary defect in the neuronalcell. Alternatively, the defect may lie primarily in endo-thelial cells, and the CNS selectivity of the diseasecould be a result of ... dilatedheart phenotype. The myocardium proliferates to anormal number of cells, but instead of building into concentric layers to form the walls of the heart, the myocardial cells form into a single layer,...
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Báo cáo khoa học: New insights into Fragile X syndrome Relating genotype to phenotype at the molecular level docx

Báo cáo khoa học: New insights into Fragile X syndrome Relating genotype to phenotype at the molecular level docx

... lack of FMRP function as the primary cause of the syndrome.In spite of its key importance, the effect of the I304N mutation on the structure and function of FMRP is still unclear, and there ... investigations of the I304N mutation play a key role in Fragile X research,there is no consensus in the Fragile X field on either the structural or functional consequences of the muta-tion.Because of the ... name from the physical‘fragility’ of the chromosome. Chromosome breakageoccurs at the tip of the X chromosome at the FRAXAlocus, Xq27.3. The fragility is associated with anexpansion of CGG repeats...
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báo cáo hóa học:

báo cáo hóa học: " Cultural adaptation into Spanish of the generalized anxiety disorder-7 (GAD-7) scale as a screening tool" pot

... complete the scale.Conclusion: After the cultural adaptation process, a Spanish version of the GAD-7 scale was obtained. The validity of its content and the relevance and adequacy of items in the ... validitySince the area under the receiver operating characteris-tic curve (ROC curve) reached a value of 0.957 (SE =0.014, p < 0.001), the null hypothesis of the area havinga value of 0.5 in the ... prevalence of 12% in the European adult population [5], 12-month prevalencein the adult population of 2% to 3%, a nd a lifetime pre-valence of 5% [5]. According to data from the EuropeanStudy of the...
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