báo cáo hóa học:" More insights into the immunosuppressive potential of tumor exosomes" pptx

... 2004:9683-9688. BioMed Central Page 1 of 4 (page number not for citation purposes) Journal of Translational Medicine Open Access Editorial More insights into the immunosuppressive potential of tumor exosomes Veronica ... through the expression of HLA/peptide complexes [6]. Based on these and following observations about the role of exosomes in antigen presentation...

Ngày tải lên: 18/06/2014, 15:20

... proton from the catalytic Cys pres- ent at the N-terminus of the helix to the His of the dyad [19,50,51]. The first stage of catalysis is mediated by the highly active thiolate ion of the Cys. Biochemi- cal ... at the bottom of the subsite is conserved in ervatamins. Compared to a Ser in the equivalent position of papain, the role of Leu here is to restric...

Ngày tải lên: 18/02/2014, 16:20

... antibodies to the subunits of the yeast bc 1 complex indicated on the left side of the blots. 1212 V. Zara et al. (Eur. J. Biochem. 271) Ó FEBS 2004 Further insights into the assembly of the yeast ... encoded in the nucleus, synthesized by cytosolic polysomes, and then imported into mitochondria, thereby reaching their final location in the inner membrane [17]. The...

Ngày tải lên: 19/02/2014, 12:20

... sequenced. Of these, 10 clones were found to encode the LC2 and LC1 sub- units. Others were found to encode other variants of the C-lectin-like venom proteins. The amino acid sequences of both subunits ... endothelial cells. The important role of these glycans in pharmacokinetics has been demonstrated by the slower and smaller increment of FDP in vivo after the injection...

Ngày tải lên: 07/03/2014, 06:20

... the cytosol. This observation allows the further determination of the concentration of drug free in the cytosol of resistant cells. The determination of k a requires also the measurement of the ... the rate of passive diffusion of the dye through the plasma membrane. This cannot be done by the simple measurement of the increase of the fluorescence si...

Ngày tải lên: 08/03/2014, 08:20

... molecules of the cofactor ThDP are bound in the canonical V conformation at the interface between the PYR domain and the PP domain of two subunits of the functional dimer. The main chain oxygen of G421 ... The main chain nitrogens of residues I322 and I303 interact with nitrogen atoms of the adenine ring and the c-carboxyl group of the side chain of resid...

Ngày tải lên: 06/03/2014, 11:20

... com- plete loss of any of the three CCM proteins within endothelial cells lining the cavernous capillary cavities. These data were an important step towards the elucidation of the mechanisms of this ... PDCD10. The expression of the mRNA in lymphoblastoid cell lines of the patient was shown to be significantly decreased suggesting that the inter- ruption of this g...

Ngày tải lên: 15/03/2014, 10:20

... exhibit the same pheno- type as the heg mutant fish – that of the dilated heart covered by a single layer of myocardium. The similar- ity of the phenotype in these nonsense alleles suggested that these ... to the endothelium, with a primary defect in the neuronal cell. Alternatively, the defect may lie primarily in endo- thelial cells, and the CNS selectivity of the...

Ngày tải lên: 15/03/2014, 10:20

... lack of FMRP function as the primary cause of the syndrome. In spite of its key importance, the effect of the I304N mutation on the structure and function of FMRP is still unclear, and there ... investigations of the I304N mutation play a key role in Fragile X research, there is no consensus in the Fragile X field on either the structural or functional consequences...

Ngày tải lên: 30/03/2014, 15:20

... complete the scale. Conclusion: After the cultural adaptation process, a Spanish version of the GAD-7 scale was obtained. The validity of its content and the relevance and adequacy of items in the ... validity Since the area under the receiver operating characteris- tic curve (ROC curve) reached a value of 0.957 (SE = 0.014, p < 0.001), the null hypothesis of t...

Ngày tải lên: 18/06/2014, 19:20