báo cáo hóa học:" The cancer secretome: a reservoir of biomarkers" doc
Báo cáo khoa học: "The Formal and Processing Models of CLG" docx
... conference of the European Chapter of the ACL, ACL. 14] Pollard, Carl J. and Ivan A. Sag, 1987. "Information-Based Syntax and Semantics 1: Fundamentals", Center for the Study of Language ... a grammar formalism based on an equational theory, to an algorithm for a formalism with complex constraints attached to rules. Assume a countable set V of variables...
Ngày tải lên: 18/03/2014, 02:20
Tài liệu Báo cáo khoa học: ˚ The 1.8 A crystal structure of a proteinase K-like enzyme from a psychrotroph Serratia species docx
... [18]. The biophysical characteri- zation of SPRK did not reveal the classical cold adap- ted features [19], but still initial comparative studies showed that the catalytic turnover was at least ... SPRK also has an aspar- tic acid residue at position at 200, and with the same conformation as in the two other structures, but Asp200 forms a salt bridge to Lys253 (Ala253 and Asn250...
Ngày tải lên: 19/02/2014, 07:20
Tài liệu Báo cáo khóa học: The PAS fold A redefinition of the PAS domain based upon structural prediction ppt
... thaliana proteins also contain a PAC motif, and conversely that all PAC- annotated A. thaliana proteins contain a PAS domain. Therefore, in the case of A. thaliana,thePASandPAC motifs are inseparable, ... that not all six structures contain a PAS as well as a PAC motif, according to the PFAM database (Fig. 1D and Table 1). Each of the 958 PAS domains was modelled against e...
Ngày tải lên: 19/02/2014, 12:20
Báo cáo khoa học: The natural mutation by deletion of Lys9 in the thrombin A-chain affects the pKa value of catalytic residues, the overall enzyme’s stability and conformational transitions linked to Na+ binding pdf
... experimentally. In analogy with the values calculated in enzymatic experiments, an increase of % 0.5 pK units of the His57 in DK9 mutant was also calculated analyzing the NAPAP data set (Table 1C). ... DK9 thrombins. The change in pK a value of the catalytic His residue in the mutant thrombin implies that the deletion of Lys9 allosterically affects the conformational...
Ngày tải lên: 07/03/2014, 12:20
Báo cáo khoa học: Missense mutations as a cause of metachromatic leukodystrophy Degradation of arylsulfatase A in the endoplasmic reticulum potx
... and 25 min after synthesis. The maturation of these late forming epitopes is accompanied by a further maturation of epitopes A2 and A5 . After 25 min of chase, precipitation with mAbs A2 and A5 is ... mechanisms cause ASA deficiency. In about half of the examined cases the mutant enzymes are retained in the ER [2,9,10], in the other half, enzymes can leave the ER and...
Ngày tải lên: 07/03/2014, 17:20
Báo cáo khoa học: The calpain 1–a-actinin interaction Resting complex between the calcium-dependant protease and its target in cytoskeleton doc
... in the absence and in the presence of calcium, with an important increase in the affinity in the presence of calcium. Furthermore, the cleavage of asm by calpain 1 generates a fragment of 95 kDa ... found within the 10 kDa C-terminal domain of the a- actinin molecule. The inability of the 95 kDa chain (issued from the cleavage of asm by Calp1) to interact w...
Ngày tải lên: 07/03/2014, 21:20
Báo cáo khoa học: The proximity between C-termini of dimeric vacuolar H+-pyrophosphatase determined using atomic force microscopy and a gold nanoparticle technique ppt
... electrotransblotting apparatus (Nova Blot, Amersham Pharmacia Biotech, Piscataway, NJ, USA). The blots were incubated with the rabbit polyclonal antibody raised against the MAP (Mito- gen-activated protein kinase)-conjugated ... height values of the cytosolic and luminal sides. In addition, the theoreti- cal ratio of the total amount of amino acids on the cytosolic and lum...
Ngày tải lên: 16/03/2014, 02:20
Báo cáo khoa học: The molecular chaperone a-crystallin incorporated into red cell ghosts protects membrane Na/K-ATPase against glycation and oxidative stress ppt
... provided against Na/K-ATPase inactivation was not due to the removal of fructose by binding to a- crystallin, BSA was resealed (in the same manner and concentration as that of a- crystallin) and incubated with ... several pathologic states, in particular heart disease, hypertension and cataract. Altered Na + and K + concentrations are observed in many forms of human cataract and c...
Ngày tải lên: 17/03/2014, 03:20
Báo cáo Y học: The mitochondrial-lysosomal axis theory of aging Accumulation of damaged mitochondria as a result of imperfect autophagocytosis ppt
... Georgetown, Texas. 25. Brunk, U.T. & Terman, A. (1999) The mitochondrial-lysosomal axis theory of cellular aging. Understanding the Basis of Aging: the Roles of Mitochondria, Free Radicals, and Antioxidants (Cadenas, ... 774–779. 48. Yoneda, M., Chomyn, A. , Martinuzzi, A. , Hurko, O. & Attardi, G. (1992) Marked replicative advantage of human mtDNA car- rying a poin...
Ngày tải lên: 17/03/2014, 23:20
Báo cáo khoa học: The )148 to )124 region of c-jun interacts with a positive regulatory factor in rat liver and enhances transcription Dipali Sharma*, Sujata Ohri and Aparna Dixit ppt
... fragment. The parameter for the degree of retardation of a linear DNA fragment bound in a complex with its specific factors reflects the molecular mass of the bound protein(s), as the molecular mass of DNA ... )124 of c-jun and stimulates transcription. Materials and methods Reagents and animals All chemicals were of reagent grade and were from Sigma Chemical Co. unles...
Ngày tải lên: 23/03/2014, 20:22