... sense of humour: the informationdemands in genomicsarestaggering. The genomecontainstwokinds of digitalinformation,onethatencodes the proteinandRNA‘molecularmachines of life’,and the otherbeing the regulatorynetworksthatspecifyhowthesegenesareexpressed in time,spaceandamplitude.DNAinformationislayeredandarranged in ahierarchy,startingwith the gene,then the RNA, then the protein, then the protein interactions, then the proteincomplexes,then the networks of proteincomplexes in a cell,then the tissues andorgans,then the individualorganism,followedbypopulationsand the ecosystems in whichtheylive. In thiskind of discoveryscience,masteringsuchvastquantities of information to answerimportantquestionsisaskillandanart.And the hardware? The firstautomatedsequencingmachinetookaday, in 1986, to sequence250 of the threebillionbasepairs.Ittook the humangenomeprojecttenyears to sequence the humangenome,twoyearsshorterthanpredicted;and the privatecompanyCelerawithitsso-calledshotgunapproachtooklessthan the public consortium’s ... of humanbeings,wenowknow,terriblywrong.Heclaimedthat the sex of apersonwasdeterminedby the heat of the malepartnerduringintercourse. The moreheated the passion, the greater the probability of maleoffspring.Hehadcounselledelderlymen to conceive in the summeriftheywished to havemaleheirs.ScottGilbert in histextDevelopmentalbiologysaysaboutAristotlethathe‘promulgatedaverystraightforwardhypothesis of sexdetermination.Womenweremenwhosedevelopmentwasarrestedtoo ... Or,perhaps,itrelated to tradingwithneighbours,or,moreonadeeplyexistentiallevel,observing the astronomical,with,asGeorgesIfrahputsitsobeautifully in the Universalhistory of numbers,afascinationwith the regularity of the phases of the moon, the eternalreturn of dayandnight, the cycle of the seasons’or,wemightadd,given the context, the ellipticalphases of the tides of greatandmarvellousoceans(Ifrah2000:xvi). In the history of counting, the SanandKhoiperhapsjoinedotherhumanbeingsand, in observingthatbirdshavetwowings,animalsfourlegs,andtheytenfingers to theirhandsandtentoes to theirfeet,developedanumberingsystemusingtheirfingersortoesas the baseten, the mostcommontype of countingfoundamongearlierpeoples.Orperhapstheyjoined the Mayans,Aztecs,CeltsandBasqueswholookeddownattheirfeetandrealisedthattheirtoescouldbecountedlikefingersandchose the muchmoreunusualarithmeticbase of 20.SCI...