... GPCR, G protein-coupled receptor; HR, hydrophobicregion; IMPAS, intramembrane proteases; NTF, N-terminal fragment; PS, presenilin; PSH, presenilin-homolog; PSL, presenilin-like; SPP,signal peptide ... aph-1 and pen-2 [3,4]. Thiscomplex is responsible for the intramembrane proteo-lysis of type I membrane proteins, such as amyloid-bprecursor protein (APP) and Notch. PS has 10Keywordspresenilin; ... Ashman K &Martoglio B (2002) Identification of signal peptide pep-tidase, a presenilin-type aspartic protease. Science 296,2215–2218.Transmembrane topology of presenilin A. Henricson et al.2732...