... 34%between dNK and dGK [29], and 47% between dGK and dCK [28], and the structures of dNK, dGK and dCKappeared to be very similar [27,28]. Despite the very lowsequence identity of the cellular ... V106I, V106K, V106L,V106M, V106Q and V106T. We then characterized theenzymatic properties of the mutant enzymes.Theapparentnativesizesofthe–ATPformsofV106WT and of the mutant recombinant enzymes ... region of HSV1-TK.Aminoacid106ispositionedinanareaofTK1that is (a) highly conserved among vertebrates and viruses of the pox family and may be important for the regulation and substrate affinity of...