scientific american - 1997 01 - parkinson''s disease

... Analysis42 Scientific American January 1997 CYBER VIEW No More 9 to 5 DAVID SUTER Copyright 1996 Scientific American, Inc.Copyright 1996 Scientific American, Inc. R oughly once a second, a subatom- ic ... SINIBALDI Tony Stone Images Copyright 1996 Scientific American, Inc.Copyright 1996 Scientific American, Inc. News and Analysis Scientific American January 1997 31 sur...

Ngày tải lên: 12/05/2014, 15:20

... KOYUKI SMITH MICHAEL CRAWFORD Copyright 1997 Scientific American, Inc. News and Analysis32 Scientific American November 1997 I ’ve got 10 kids out in the Gulf to- day diving,” says Lt. Commander Robert ... form a connection. OIL IN 4-D Time-lapse software boosts oil recovery APPLIED GEOLOGY COURTESY OF JEAN-CLAUDE BRADLEY Copyright 1997 Scientific American, Inc. VIRUS-KILLING...

Ngày tải lên: 12/05/2014, 15:31

... 3,5,7,3  ,4  -pentahydroxyflavonol-3-O-beta- D - glucopyranoside, 3,5,7,3  ,4  -pentahydroxyflavonol-3-O-beta- D -galactopyranosi-de, and 3,5,7,3  ,4  -pentahydroxyflavonol-3-O-alpha-l-arabinofuranoside ... flavonol acylglycosides quercetin-3-O-[4   -( 3-hydroxy-3-methylglutaroyl)]-alpha-rhamnose and kaempferol-3-O-[4  -( 3- hydroxy-3-methylglutaroyl)]-alpha-rhamnose. Compo...

Ngày tải lên: 25/10/2013, 05:20

... UbcH8, to ubiqui- tinate a variety of substrates. These include synphilin-1, CDCrel-1, parkin-associated endothelin receptor-like re- ceptor (Pael-R), an O-glycosylated isoform of a-synuclein (aSp22), ... effects of expressing PD-related mutant (and wild-type) a-synuclein in transgenic animals (Ferna- gut and Chesselet, 2004). Expression of mutant (A53T, A30P) or wild-type a-synuclein in tran...

Ngày tải lên: 14/02/2014, 17:20

... i.v. injected compounds related to L-dopa, such as: D-dopa, 3-O-methyldopa, DA, D, L-dops, and also 5-HTP. This should have convinced the doubters that the L-dopa effect could not have been a ... among primary motor cortex neurons in the 1-methyl- 4- phenyl-1,2,3,6-tetrahydropyridine primate model of Parkinson’s disease. J Neurosci 22: 4639 –4653 Heimer G, Bar-Gad I, Goldberg JA, Bergman...

Ngày tải lên: 14/02/2014, 17:20

... glyceraldehyde-3-phosphate dehydrogenase; GO, Gene Ontology; GSK-3b, glycogen synthase kinase 3b; GSTp, glutathione S-transferase p; LB, Lewy bodies; MTT, 3-( 4,5-dimethylthiazol-2-yl )-2 ,5-diphenyltetrazolium ... the 3-( 4,5-dimethylthiazol- 2-yl )-2 ,5-diphenyltetrazolium bromide (MTT) assay (Fig. S1). Because dopamine upregulates a-synuclein expression [13], we measured the level...

Ngày tải lên: 15/02/2014, 01:20

... neurodegenerative diseases, particularly PD [3]. Defects in mitochon- drial complex I have been closely linked to PD. Environmental toxins causing parkinsonism such as 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine ... with a slow disease progression and a good response to l-Dopa. DJ-1 is localized to both the nucleus and cytoplasm in differ- ent cell types [22,23], although a pool of wild-ty...

Ngày tải lên: 18/02/2014, 14:20

... 3BG, UK Fax: +4 4-0 20 7-8 3 3-1 016 Tel: +4 4-0 20 7-8 2 9-8 722 E-mail: j.hardy@ion.ucl.ac.uk (Received 7 July 2008, revised 2 September 2008, accepted 25 September 2008) doi:10.1111/j.174 2-4 658.2008.06709.x Heterozygous ... enzyme in sphingolipids biosynthesis, catalyzing the pyridoxal- 5- prime-phosphate-dependent condensation of l-serine and palmitoyl-CoA to 3-oxosph...

Ngày tải lên: 18/02/2014, 14:20

... Parkinson’s disease is a disease of the nervous sys- tem that gets worse over time. We also describe Parkinson’s disease as a chronic, pro- gressive neurologic disease. Chronic means “of long du- ration”; ... different dis- ease courses are separated into “benign” and “malig- nant” forms. In our experience, most so-called malig- nant cases of Parkinson’s disease have proved to be oth...

Ngày tải lên: 19/02/2014, 04:20

... basic neuroanatomical terms used in this chapter are found in Table 1-2 , with further illustration in Figs. 1-1 , 1-2 , and 1-3 . Characteristics of Gait Walking is a fundamental activity, and a ... Parkinson’s Disease 85 Demetrius M. (Jim) Maraganore, MD 6 Parkinson’s Disease: Etiologic Considerations 91 Peter A. LeWitt, MD 7 Medication Strategies for Slowing the Progression of...

Ngày tải lên: 05/03/2014, 23:20