cytotoxic drug resistance mechanisms
cytotoxic drug resistance mechanisms
... reduced Drug Resistance 1 1 1 From: Methods in Molecular Medicine, Vol. 28: Cytotoxic Drug Resistance Mechanisms Edited by: R. Brown and U. Böger-Brown © Humana Press Inc., Totowa, NJ Drug Resistance The ... exposed to a cytotoxic drug. The duration of exposure is usually determined as the time required for maximal From: Methods in Molecular Medicine, Vol. 28: Cytotoxic...
Ngày tải lên: 10/04/2014, 22:15
Báo cáo khoa học: Structural insights into mechanisms of non-nucleoside drug resistance for HIV-1 reverse transcriptases mutated at codons 101 or 138 pot
... for reducing drug resistance. J Mol Biol 284, 313–323. 34 Ren J, Nichols C, Bird L, Chamberlain P, Weaver K, Short S, Stuart DI & Stammers DK (2001) Structural mechanisms of drug resistance ... for the development of anti-HIV drugs used in multidrug combination therapy regimens [2]. HIV-1 RT contains two distinct inhibitor binding sites for Keywords drug resistance; HIV-1 reve...
Ngày tải lên: 16/03/2014, 13:20
Báo cáo y học: "Current Status of Methods to Assess Cancer Drug Resistance"
... targeted drugs goes on. Potential biomarkers for the prediction of drug response are several proteins which play a role in drug resistance mechanisms. Such cellular factors are resistance ... before drug treatment starts (intrinsic resistance) , and in a large proportion of the remaining half resistance develops during treatment (acquired resistance) [1]. All efforts to over...
Ngày tải lên: 25/10/2012, 11:10
Báo cáo y học: "Advances in Molecular Diagnosis of HBV Infection and Drug Resistance"
... sequences from data banks (i.e., genotypic resistance) [24]. 5. Monitoring HBV Drug Resistance Several options are currently available to monitor HBV drug resistance, and can generally be divided ... virus resistance in vitro and molecular mechanisms of nucleoside resistance. Semin Liver Dis 2002;22:23-31. 21. Doo E, Liang TJ. Molecular anatomy and pathophysiologic implication...
Ngày tải lên: 03/11/2012, 09:41
Tài liệu Báo cáo khoa học: Effect of sequence polymorphism and drug resistance on two HIV-1 Gag processing sites pdf
... sequence of HIV-1 IIIB , while residues appearing only in drug resistance are in bold [9–13]. Mutations underlinedintheFigurealsoappearedindrugresistanceonapar- ticular natural sequence background, ... polymorphism (P), mutation appearing only in drug resistance (R, see Fig. 1). If two mutations occurred and one of them was occurring only in drug resistance, the cleavage site was c...
Ngày tải lên: 21/02/2014, 03:20
Báo cáo khoa học: Identification of carbonic anhydrase 9 as a contributor to pingyangmycin-induced drug resistance in human tongue cancer cells ppt
... tag; HIF, hypoxia-inducible factor; MDR, multidrug resistance; MDR1, multidrug resistance transporter 1 (p170, p-gp); MMC, mitomycin; MRP1, multidrug resistance- associated protein 1; MT, metallothionein; ... the resistance was not associated with multidrug resistance transporter 1 (p170, p-gp), multi- drug resistance- associated protein 1 and breast cancer resistance protein ov...
Ngày tải lên: 06/03/2014, 22:21
Báo cáo khoa học: Inhibition of PI3K/Akt partially leads to the inhibition of PrPC-induced drug resistance in gastric cancer cells pdf
... 689 Multidrug resistance (MDR) is one of the major causes of failure of chemotherapy of human malignan- cies. Studies have shown that cellular drug resistance is mediated by various mechanisms ... a certain role in drug accumulation in gastric cancer cells, which could induce drug resistance in SGC7901 cells by decreasing accumulation and increasing release of these drugs (ADR a...
Ngày tải lên: 07/03/2014, 03:20
Low Occurrence of Tuberculosis Drug Resistance among Pulmonary Tuberculosis Patients froman Urban Setting, with a Long-Running DOTS Programin Zambia docx
... isoniazid and rifampicin was 3.3% for each drug, and one case of resistance to both isoniazid and rifampicin (multidrug resistance) was detected. No resistance to kanamycin or ofloxacin was detected. ... to drug susceptibility testing (DST) is limited and not performed routinely, the picture of drug resistance in Zambia may be imprecise. This study was set out to document the preva...
Ngày tải lên: 22/03/2014, 18:20
Understanding Tuberculosis – New Approaches to Fighting Against Drug Resistance Edited by Pere-Joan Cardona potx
... acting diagnostic tools, drugs and vaccines. 1.2 Drug- resistant TB Drug- resistant TB is a result of mycobacterial strains that do not respond to drug treatment. Drug resistance has in the recent ... difficult to obtain. Resistance to one drug within a class generally means resistance to all drugs within that class, but a notable exception is rifabutin for which rifampicin -r...
Ngày tải lên: 23/03/2014, 17:20
Patterns of drug resistance in pulmonary tuberculosis cases in the Izmir district, Turkey pdf
... accompanying other drug resistance. Polydrug resistance is resistance of M. tuberculo- sis strain to two or more of the first-line drugs. MDR is a special subgroup of polyresistance, in which there is resistance ... contact with the drugs (Mitchison, 1984). Monoresistance is defined as resistance to one of the first-line drugs. Any drug resistance is indicated as total resist-...
Ngày tải lên: 29/03/2014, 03:20