advances in clinical trial biostatistics - nancy l geller

... phase I trial design will be illustrated using examples based on two pha se I clinical trials conducted at the Fox Chase Cancer Center. 5-FU Trial In this trial a total of 12 patients with malignant ... potentially life threatening and the target probability of toxic response is correspondingly low, generally less than or equal to 1/3. As an example, in a phase I trial evaluatin...

Ngày tải lên: 08/04/2014, 13:10

... randomised, non-blinded, single- centre clinical trial in a medical/surgical ICU. Patients were randomly assigned to receive either intensive insulin therapy to maintain glucose levels between 80 ... Deerfield, IL, USA). The standard concentration of insulin (Humulin R, Eli Lilly and Company, Indianapolis, IN, USA) was 100 units in 100 ml of 0.9% saline solution. In the standard in...

Ngày tải lên: 25/10/2012, 10:35

... ma- nipulation. Studies have also shown that small doses of orally administered undenatured type II chicken collagen inhibit killer T-cell attack (15). The present clinical trial evaluated ... oral type II collagen. Results of a multicenter, double-blind, placebo-controlled trial. Arthritis Rheum 1998; 41(2):29 0-7 . 9. Barnett ML, Combitchi D, Trentham DE. A pilot trial of oral...

Ngày tải lên: 26/10/2012, 09:48

... Raangs, G., Wagendorp, A., Klijin, N., Bindels, J. & Welling, G. (2000). Analysis of intestinal flora development in breast-fed and formula-fed infants by using molecular identification and ... probiotic Lactobacillus casei DN-114 001 in prevention ofradiation- induced diarrhea: results from multicenter, randomized,placebo-controlled nutritional trialjordi giraltInt. International...

Ngày tải lên: 12/02/2014, 16:20

... Meta-analyses of double-blind, placebo-controlled clinical trials have concluded that probiotics, particularly Lactobacillus GG, are effective in treatment of acute infectious diarrhoea in infants ... units of lymphoid cells, single lymphocytes scattered in the lamina propria and intraepithelial lymphocytes spread in the intestinal epithelia. The immune system of infants is not...

Ngày tải lên: 07/03/2014, 20:20

... other H. in uenzae strains [15,17,32,33]. Recently, the presence of sialyl-lacto-N-neotetraose, a-Neu5Ac-(2fi3)-b- D -Galp- (1fi4)-b- D -GlcpNAc-(1fi3)-b- D -Galp-(1fi4)-b- D -Glcp was describedinstrainRM118,whereitwassituatedatHepI [19]. ... b- D - Glcp residue (labelled GlcI) linked to HepI, and in turn, is substituted by a b- D -Galp residue at O-6 [i.e. b- D -Galp- (1fi6 )- L -a- D...

Ngày tải lên: 08/03/2014, 08:20

... CLINICAL AND MOLECULAR ADVANCES IN ANKYLOSING SPONDYLITIS Edited by Jacome Bruges-Armas Clinical and Molecular Advances in Ankylosing Spondylitis 6 Fig 2. Bamboo stick. Clinical ... agents Clinical and Molecular Advances in Ankylosing Spondylitis 8 reduce pain, but also inflammation itself. Long-term intake of this medication is generally recommend...

Ngày tải lên: 17/03/2014, 02:20

... cell biotechnology to produce enhanced levels of medic- inally important, value-added secondary metabolites in intact plants, and plant cell cultures. These studies involve metabolic engineering ... vari- ability and productivity; (4) establishment of cell suspension cultures; (5) analysis of metabolite levels in cell suspension cultures; (6) selection of cell lines based on single cells;...

Ngày tải lên: 02/10/2012, 10:48

Ngày tải lên: 02/11/2012, 10:09

... interferon (once-weekly subcutaneous injection). Clinical trials of pegylated interferons have provided encouraging results. In an early, phase II, proof-of-concept trial, peginterferon alfa-2a (40KD) ... effect of IL-2 on chronic HBV infection. Interleukin-12 (IL-12) IL-12 is a heterodimeric cytokine produced by antigen-presenting cells that have the ability to induce interferon-γ (I...

Ngày tải lên: 02/11/2012, 11:17