molecular biology in medicinal chemistry - d steinhilber

... Schneider (eds.) Protein-Ligand Interactions Vol. 19 2003, ISBN 3-5 2 7-3 052 1-1 R. E. Babine, S. S. Abdel-Meguid (eds.) Protein Crystallography in Drug Discovery Vol. 20 2003, ISBN 3-5 2 7-3 067 8-1 A B C D E F G H I J K L M N O P 1 ... trimeric GTP-binding proteins (G-proteins). The enzyme-linked receptors include the receptor guanylyl cyclases, receptor tyrosine kinases,...

Ngày tải lên: 08/04/2014, 12:51

... wax-embedded type. Thus, Dr Young describes the value of the polymerase chain reaction in histopathology; indeed, this is already being adapted for use as an in situ method. Dr Camplejohn then describes ... method of choice for techniques such as in situ hybridization. Double-stranded DNA Labelling of a double-stranded DNA probe can be performed using nick-transla- tion (Rigby et al., 1...

Ngày tải lên: 08/04/2014, 12:51

Ngày tải lên: 11/04/2014, 09:51

... oligonucleotide was derived from b - D -2 ′,3′-dideoxyglucose and composed of (6′ Æ 4′)-hexopyranosyl re- peating units, while the latter was derived from b - D -ribose and consisted of (4′ Æ 2′)-pentopyranosyl ... grub- bing all the finest details and subtleties of the chemistry of low -molecular- mass compounds out of the depths. The deer grazing in the untamed wilder-...

Ngày tải lên: 03/04/2014, 12:14

... described in Subheading 3.1. or obtained from the DSMZ. 10. Deoxy-nucleotide triphosphate mixture (dNTP mix): mixture contains 5 mM each of deoxyadenosine triphosphate (dATP), deoxycytidine triphosphate ... single-stranded long internal control DNA and the shorter single-stranded mycoplasma DNA form. • Contaminations of reagents with mycoplasma-specific DNA or PCR product are revealed by a...

Ngày tải lên: 08/04/2014, 12:50

... structures into two groups:  Purine; double ringed structure (Adenine and Guanine).  Pyrimidine; single ring structures (cytosine and thymine).  Sugar  Phosphate group Dr./Salwa Hassan Teama 2012 ... Introduction To Molecular Biology Salwa Hassan Teama M .D. Nucleotides  DNA: Four different types of nucleotides differ in nitrogenous base:  A is for adenine;  G...

Ngày tải lên: 13/03/2014, 19:13

Ngày tải lên: 17/03/2014, 15:00

... (bp) in the segment is regarded as independent of others and produced randomly by nature based on a roll of a four-sided die (maybe loaded). Although very simple and un- realistic, this model ... biomedical industry in recent years is due to the increased availability of huge amount of biomedical data and the imminent need to turn such data into useful information and knowled ge. The know...

Ngày tải lên: 08/04/2014, 12:45

... first identified in budding yeast, leading to the discov- ery of highly conserved MAD (mitotic arrest deficient) and BUB (budding uninhibited by benzamidazol) genes, encoding the spindle-assembly ... Catarin, B., Herskowitz, I., Deshaies, R. J., and Peter, M. (1997) Phosphorylation- and ubiquitin-dependent degradation of the cyclin-dependent kinase in- hibitor Far1p in budding yeast. Ge...

Ngày tải lên: 08/04/2014, 12:50

... already threatened or endangered marine species, neither should they drill deep underground to take up the already depleted petroleum reserves. What modern people should be doing is to design ... may find this book exactly what you have been looking for. Acknowledgement added in the second printing Perhaps nothing is more gratifying than preparing one’s first book for the second printing, ....

Ngày tải lên: 08/04/2014, 12:50