molecular and cellular biology of neuroprotection in the cns - christian alzheimer

... are ligand-gated ion channels, which are named after agonists that bind preferentially to these receptor subtypes. They include α-amino-3-hydroxy-5-methyl-isoxalole-4-propionate (AMPA), kainate and N-methyl-D-aspartate ... for the implication of apoptotic pathways in epilepsy-associated neuronal cell death. 6 1-6 6 In conclusion, the mode of cell death in SE-induced brain p...

Ngày tải lên: 08/04/2014, 12:51

... quaternary amino acid derivatives (Pro, GB, b -alaninebetaine and pro- linebetaine), tertiary amines (1,4,5,6-tetrahydro- 2-mehyl-4-carboxyl pyrimidine), and sulfonium compounds (choline- O -sulphate, ... Amino Acids, Proline, and Amides It has been reported that amino acids (such as ala- nine, arginine, glycine, serine, leucine, and valine, the nonprotein amino acids citrulline...

Ngày tải lên: 14/03/2014, 10:20

... usage of lighting defines characters and allows a differentiation of the sinfulness of 'David' and the 'Wife of Uriah' and the holiness of the Minister. The character of the Minister ... as the hands of the other characters are bare. This is highlighted in the shot showing bare white hands putting coins into the dish. Like the li...

Ngày tải lên: 21/03/2014, 22:02

... the antisera r-anti-l (made in rat) and gp-anti-dW4 (produced in guinea pig), two antisera discriminating CHH isomers (gp-anti-pQl made in guinea pig and rb-anti- pQd in rabbit) [38] and an antiserum ... the d-residue being found near the N-terminal end, between the sec- ond and the fourth position of the sequence. Conse- quently, we hypothesized that the d-res...

Ngày tải lên: 18/02/2014, 11:20

... to the actin cytoskeleton via the binding of beta- and gamma-cate- nin to alpha-catenin [8]. Gap junctions have been iden- tified as BBB components [7]; however, their role in the function of the ... VEGF expression and induced angiopoietin-1 (Ang-1), thereby promoting the expression of tight junction proteins and strengthening the bonds between brain endothelial cell...

Ngày tải lên: 18/02/2014, 11:20

... apoptosis. Results Identification of VBARP as HIV-1 Vpr-interacting protein The HIV-1 Vpr-interacting protein, VBARP, was iden- tified using the yeast two-hybrid system as previously described [9]. A 915-bp fragment was initially ... protein containing a single ankyrin repeat that interacts with HIV-1 viral protein R (Vpr) and we designated this protein as Vpr-binding ankyrin repeat pro...

Ngày tải lên: 07/03/2014, 21:20

... series of events beginning with the TNFa-mediated prevention of the effect of insulin on Foxa2 localization and lead- ing to the abrogation of insulin inhibition of gluconeo- genesis and glucose ... inhibition of insulin signalling in the liver is pri- marily reflected by the attenuation of the insulin-medi- ated inhibition of gluconeogenic gene expression. As...

Ngày tải lên: 16/03/2014, 02:20

... binding subsite. Substrate binding induces conformational changes involving the ArgA14 5- PheA146 fragment of the protein chain, acting as a flap, first opening and then closing the groove [45]. The ... of the side chain d-guanidino group of this residue are involved in H-bonding as follows: Ne with the O atom of the main chain CO group of the TrpB240; Ng 1 shar...

Ngày tải lên: 16/03/2014, 16:20

... germinal center kinase-3 (GCK-3) is a mem- ber of the GCK-VI subfamily of sterile-20 (Ste20) ser- ine-threonine protein kinases that includes vertebrate oxidative-responsive 1 (OSR1) and proline-alanine-rich Ste20-related ... suggesting that it may be involved in discriminating osmotic from other stimuli that activate OSM-9 and ⁄ or OCR-2. Although more work is needed to understan...

Ngày tải lên: 30/03/2014, 03:20