suzuki - drugs and poisons in humans - handbook of practical analysis (springer, 2005)

... post- mortem inspection, or by introducing a thin vinyl tube into the ventricles a er removal of some parts of the brain at autopsy. Cerebrospinal fl uid (CSF) Drugs and Poisons in Humans A Handbook ... for analysis of drugs and poisons for living subjects. A blood concentration of a toxin can be an indicator for estimation of intoxication degree. Urine sometim...

Ngày tải lên: 03/04/2014, 12:05

... cooled standard solution of isobutyl nitrite (10 µg/mL) is added to the mixture of 0.4 mL of blank blood and 0.4 mL of IS- containing pentane solution in a glass vial with a Te on-septum screw ... (from the sam- pling until injection to GC, and from the standard solution to a test specimen). In principle, the sampling, extraction and GC analysis should be made at low...

Ngày tải lên: 18/10/2013, 00:15

... the use of t-BDMS derivatization of EMPA, the  nal solution containing a large amount of the derivatization reagent has to be injected into GC/MS, resulting in the marked contamination of the ... DAEMO (IS solu- tion); a 1- L of it is injected into GC/MS for analysis f . 621VX and its decomposition products ii. Analysis of EMPA [2, 8] i.  e remaining aqueous layer...

Ngày tải lên: 18/10/2013, 00:15

... the analysis of ∆ 9 -THC-11-oic acid in urine is essential. In this chapter, a GC method for analysis of cannabis components in plant specimens and a GC/MS method for ∆ 9 -THC-11-oic acid in ... measure- ments, the ISs such as 5α-cholestane and 5’-nor-∆ 8 -THC-4′-oic acid become useful. i)  e solution of diazomethane in ethyl ether can be prepared from 1-methyl-3-ni...

Ngày tải lên: 24/10/2013, 19:15

... analysis of the conjugated forms of opiates, the authentic standards of mor- phine-3-glucuronide (M-3-G) and morphine-6-glucuronide (M-6-G) are necessary. In U.S.A. and Europe, it is easy to obtain ... at 220 nm) of the authentic morphine and its related compounds. A: morphine-6-sulfate; B: normorphine-3-glucuronide; C: morphine-3-glucuronide; D: morphine- 6-glucuronide; E:...

Ngày tải lên: 24/10/2013, 19:15

... of methemoglobin in blood of normal subjects is not higher than 1–2 % [1]; in case of higher concentrations of methemoglobin, it is called methemoglobinemia. Especially in newborn babies and ... methemoglobin is produced, its reduction into hemoglobin starts by the action of methemo- globin reductase (identical with cytochrome b 5 reductase requiring NADH as a cofactor)...

Ngày tải lên: 24/10/2013, 19:15

... 165 n-heptane 165 n-hexane 165 N-methyl- 1-( 3,4-methylene- dioxyphenyl )-2 -butan- amine 229 N-methyl- 1-( 3,4-methylene- dioxyphenyl )-3 -butan- amine 233 N-methyl-bis(tri uoro- acetamide) 371 N-methyl-N-(trimethylsilyl )- tri ... poisoning 104 hydroxyl aprenolol 373 14-hydroxy-LSD 228 4-hydroxy-3-methoxy- amphetamine 230 4-hydroxy-3-methoxy- ethylamphetamine 238 4-hydroxy-3-m...

Ngày tải lên: 24/10/2013, 19:15

... (1977) Cocaine and benzoylecgonine excretion in humans. J Forensic Sci 22:697–707 15) Amber J (1985) The urinary excretion of cocaine and metabolites in humans: a kinetic analysis of published ... Eluent-2: chlo- roform/isopropanol (9:1, v/v) 216 Cocaine and its metabolites tipyrine as ISs for cocaine; ketamine su ered from variation of its peak height and antipy- rin...

Ngày tải lên: 29/10/2013, 01:15

... and quantitation of both therapeutic and toxic levels of pen- tazocine in blood.  e recovery of pentazocine using the Sep-Pak C 18 cartridge was close to 100 % for both whole blood and urine ... (IS) and at m/z 285 plus 217 (pentazocine) were used at the retention times of 3–7 min and 7–8 min, respectively. The amount of pentazocine and IS spiked into 1 mL of blan...

Ngày tải lên: 29/10/2013, 02:15

... powerful hallucinogenic drugs of abuse. LSD was explosively abused in U.S.A. in the latter half of the 1960s. In Japan, the amount of seizure of LSD is much smaller than that of methamphetamine. However, ... pharmaco- logical activity can be obtained by oral administration of as small as 20–75 µg of LSD.  e ab- sorption of LSD from the digestive tract is rapid and...

Ngày tải lên: 08/11/2013, 01:15