Báo cáo Y học: Conformationally constrained human calcitonin (hCt) analogues reveal a critical role of sequence 17–21 for the oligomerization state and bioactivity of hCt ppt
Báo cáo Y học: Conformationally constrained human calcitonin (hCt) analogues reveal a critical role of sequence 17–21 for the oligomerization state and bioactivity of hCt ppt
... 791 Conformationally constrained human calcitonin (hCt) analogues reveal a critical role of sequence 17–21 for the oligomerization state and bioactivity of hCt Athanasios Kazantzis1, Michaela Waldner1, ... 3,respectively, and als o a linear control peptide for 1a ,analogue 1b.Conformational analyses by CD: studies of hCt and the analogues in aqueous buffer, pH 7.4CD spectra of hCt and analogues 1–6 ... tostabilize the a helical conformation in a flexible polypeptidechain that has an a helical propensity [51].Fig. 1. Far -UV CD spectroscopy of hCt and analogues 1–6 (A, C) and 1a, 1b, 2a, and 3a...
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Báo cáo y học: "Electronic patient record use during ward rounds: a qualitative study of interaction between medical staff"
... types of form (the observation chart, the drugchart, and the plan of the day) and a folder or binder for mis-cellaneous and patient-specific forms and papers. The obser-vation chart was A3 -size ... allowfocus on the conversation rather than the data, as describedabove, and the use of paper to provide relevant data – are notsurprising in that they address the issues of access to data and a need ... affectsinteraction and that the substantial amount of information in the EPR might distract rather than add to the interaction, and on encouraging medical staff to adjust as necessary (for exam-ple, bringing...
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Báo cáo y học: "Strict glycaemic control in patients hospitalised in a mixed medical and surgical intensive care unit: a randomised clinical trial"
... interpreta-tion, and drafting of the manuscript, NS, MB, JT, JV, JV, CA,PA, EV, JCH, AY, WP and CC participated in the study design,data acquisition and drafting of the manuscript. All authorsread and approved ... uri-nary infections, catheter-related infections and primary bacter-aemias); ICU length of stay; days of mechanical ventilation and incidence of severe hypoglycaemia defined as number of patients ... therapy is equally effica-cious in both medical and surgical patients [12]. Therefore, weconducted a randomised clinical trial to assess the efficacy and safety of intensive insulin therapy...
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Tài liệu Báo cáo khoa học: Trophoblast-like human choriocarcinoma cells serve as a suitable in vitro model for selective cholesteryl ester uptake from high density lipoproteins pdf
... Histology and Embryology,3Clinic of Obstetrics and Gynecology, Karl-Franzens University Graz, AustriaAs human choriocarcinoma cells display many of the biochemical and morphological characteristics ... represents the epithelial layerseparating the maternal and fetal circulation [18]. In the human placenta chorionic villi, a layer of syncytiotropho-blasts lies over the cytotrophoblasts, and surrounds ... contrast to primary cultures of term cytotrophoblasts which aggregate and form syncytia.In contrast to BeWo and Jeg3 cell lines, JAr cells share many of the characteristics of early placental...
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Báo cáo Y học: Double-stranded RNA-activated protein kinase interacts with apoptosis signal-regulating kinase 1 Implications for apoptosis signaling pathways docx
... in the figure legend. The phosphorylation reactionwas resolved by SDS/PAGE and visualized by autoradio-graphy. Autoradiogram was scanned and densitometricanalysis was performed with KodakDIGITAL ... not play only a structural role butrather modulates a signaling pathway of ASK1. Therefore the binding of PKR to ASK1 might cause a conforma-tional change in ASK1 for activation, of which isdependent ... a signal transducer by interacting with MAPKKKs, whichthen modifies the downstream MAPK cascade.MATERIALS AND METHODSPlasmids and DNA transfection Human PKR cDNA was kindly provided by A. Hovanes-sian...
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Báo cáo Y học: Disul®de bond formation through Cys186 facilitates functionally relevant dimerization of trimeric hyaluronan-binding protein 1 (HABP1)/p32/gC1qR docx
... BSA. Therefore, the dissociation constant for the hyaluronan±HABP1 i nteraction was calculated b y Scatchard plot analysis from the data in Fig. 5A, taking the average molecular mass of hyaluronan ... biotinylated hyaluronan,biotinylatedD-mannosylated BSA, and g C1q. The hexamergenerated by thiol-group oxidation o f native HABP1 hadgreater af®nity for its ligand than native a nd cysteine-modi®ed ... trimeric and hexameric forms of HABP1 for its various ligands, e.g. hyaluronan,D-mannosylatedBSA and gC1q, was analyzed by ELISA. HgCl2 and copper±phenanthroline treatment of HABP1 resulted...
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Báo cáo khoa học: Substrate recognition by three family 13 yeast a-glucosidases Evaluation of deoxygenated and conformationally biased isomaltosides pptx
... using the relevant deoxygenatedD-glucose as standard. The a- glucosidase catalyzed hydro-lysis was initiated by a ddition of 0.1±91 U enzyme. The limited amounts of deoxygenated analogs available ... smallest for t he6¢-deoxy ana log and largest for the 2¢-deoxy analog, whileintermediary losses in activity for 3¢ -and4 ¢-deoxy analogsdid show small variations among the enzymes (Table 1). For ... and methyl 6-S-ethyl -a- isomaltoside as the pair of conformationally biased substrate analogs(Table 3). While methyl 6-S-ethyl -a- isomaltoside washydrolyzed with twofold lower Vmax,butthesameKmasisomaltose...
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Báo cáo Y học: GNA33 from Neisseria meningitidis serogroup B encodes a membrane-bound lytic transglycosylase (MltA) pdf
... products[10]. By virtue of their ability to cleave the polysaccharidebackbone of the peptidoglycan layer, lytic transglycosylasesare thought to play a role in synthesis and degradation of the murein sacculus. ... witheach other.Lytic transglycosylases are a unique class of lysozyme-likeenzymes that catalyze cleavage of the b-1,4-glycosidic bondbetween N-acetylmuramic acid (MurNAc) and N-acetylglucosamine ... confirmingthat the protein is a lytic transglycosylase. Optimalmuramidase activity was observed at pH 5.5 and 37 °Candenhanced by Mg2+,Mn2+ and Ca2+. The addition of Ni2+ and EDTA had no significant...
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Báo cáo khoa học: Adeno-associated virus gene transfer in Morquio A disease – effect of promoters and sulfatase-modifying factor 1 pot
... keratan sulfate and chondroitin 6-sul-fate, mainly in bone and cornea [1]. Clinicalmanifestations vary from severe to attenuated formscharacterized by systemic skeletal dysplasia, laxity of joints, ... PH, Parthasarathy S, Isaacs J,Vijay S, Kieran J, Powell SK, McClelland A & WrightJF (2003) Quantification of adeno-associated virus par-ticles and empty capsids by optical density measure-ment. ... 2010)doi:10.1111/j.1742-4658.2010.07769.xMucopolysaccharidosis (MPS) IVA is an autosomal recessive disordercaused by deficiency of the lysosomal enzyme N-acetylgalatosamine-6-sul-fate sulfatase (GALNS), which leads to the accumulation of...
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Báo cáo y học: "Expression of Human Globular Adiponectin-Glucagon-Like Peptide-1 Analog Fusion Protein and Its Assay of Glucose-Lowering Effect In Vivo"
... sonicated and centrifuged to separate the supernatant and inclusion body. Part of the production was applied to 12% SDS–PAGE analysis and Western blot analysis. (A) SDS-PAGE analysis: Most of the ... circumvent the rapid inactivation and renal clearance of GLP-1 is therefore an important step toward applying them therapeutically [5, 6]. Type 2 diabetes is characterized by insulin re-sistance and ... were analyzed using one-way analysis of variance and secondary analysis for significance with the Turkey-Kramer post test. All analyses were per-formed using SPSS version 11.0 (SPSS Inc., USA)....
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Từ khóa: báo cáo y họcbáo cáo y học cổ truyềnbáo cáo khoa học y họcbáo cáo y tế học đườngmẫu báo cáo y tế học đườngbáo cáo y tế học đường cuối nămNghiên cứu tổ hợp chất chỉ điểm sinh học vWF, VCAM 1, MCP 1, d dimer trong chẩn đoán và tiên lượng nhồi máu não cấpNghiên cứu tổ chức chạy tàu hàng cố định theo thời gian trên đường sắt việt namGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANPhối hợp giữa phòng văn hóa và thông tin với phòng giáo dục và đào tạo trong việc tuyên truyền, giáo dục, vận động xây dựng nông thôn mới huyện thanh thủy, tỉnh phú thọPhát triển mạng lưới kinh doanh nước sạch tại công ty TNHH một thành viên kinh doanh nước sạch quảng ninhPhát triển du lịch bền vững trên cơ sở bảo vệ môi trường tự nhiên vịnh hạ longNghiên cứu về mô hình thống kê học sâu và ứng dụng trong nhận dạng chữ viết tay hạn chếThơ nôm tứ tuyệt trào phúng hồ xuân hươngChuong 2 nhận dạng rui roTổ chức và hoạt động của Phòng Tư pháp từ thực tiễn tỉnh Phú Thọ (Luận văn thạc sĩ)BT Tieng anh 6 UNIT 2Tranh tụng tại phiên tòa hình sự sơ thẩm theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn xét xử của các Tòa án quân sự Quân khu (Luận văn thạc sĩ)chuong 1 tong quan quan tri rui roNguyên tắc phân hóa trách nhiệm hình sự đối với người dưới 18 tuổi phạm tội trong pháp luật hình sự Việt Nam (Luận văn thạc sĩ)HIỆU QUẢ CỦA MÔ HÌNH XỬ LÝ BÙN HOẠT TÍNH BẰNG KIỀMMÔN TRUYỀN THÔNG MARKETING TÍCH HỢPTÁI CHẾ NHỰA VÀ QUẢN LÝ CHẤT THẢI Ở HOA KỲQUẢN LÝ VÀ TÁI CHẾ NHỰA Ở HOA KỲ