... placebo-controlled, randomized trials tested the efficacy of a variety of oral codeine-containing agents, including acetaminophen plus codeine and proprietary combinations of acetaminophen, codeine, ... three trials tested the efficacy of the combination of acetaminophen, aspirin, and caffeine (Excedrin®) in migraine patients (studies recently published and not included in the AHCPR Technical ... Other Medications Isometheptene and Isometheptene Combination Agents: In two placebo-controlled trials, isometheptene attained borderline significance in relieving headache pain. 13 9-1 41...