Báo cáo khoa học: The soluble form of the membrane-bound transferrin homologue, melanotransferrin, inefficiently donates iron to cells via nonspecific internalization and degradation of the protein pdf

... 4445 The soluble form of the membrane-bound transferrin homologue, melanotransferrin, inefficiently donates iron to cells via nonspecific internalization and degradation of the protein Michael R. ... (MTf2) and a novel protein isoform: Explanation for the membrane-bound and soluble forms of mel- anotransferrin? FEBS Lett. 512, 350–352. 2...

Ngày tải lên: 31/03/2014, 09:20

... many proteins impor- ted into mitochondria, the pI of the mitochondrial form of the protein is higher than that of the cytosolic protein form [65,66]. It will be surprising if the mitochondrial form ... the a-andb-isoforms are likely what makes this possible. Consequently, truncation of the C-terminal domain may be essential for the b isoform to be targeted...

Ngày tải lên: 31/03/2014, 07:20

... independently of Pbx, and does not possess the autoinhibitory function of the Hth domain. In summary, our data suggest that one function of the conserved Hth domain is to inhibit the activity of the transcriptional ... the alternative splice site in Meis3, such that both the Meis3.1 and Meis3.2 isoforms were amplified. The relative amount of each splice form a...

Ngày tải lên: 16/02/2014, 15:20

... side of the protein, indicating a possible additional binding site needed for the WAF1 promoter. Prediction of the severity of mutants in other proteins All parameters used for the predictions of ... promoter is measured. The top half shows mutants in which the activity for the p53R2 and NOXA promoters is similar to that of the wild-type, whereas the activity...

Ngày tải lên: 18/02/2014, 11:20

... obtained with the transition at posi- tions 1915 and 1917. These mutations had an effect on the formation of pseudouridine exclusively at the mutant position and did not affect either of the other two ... belongs to the RluA family [2]. Binding of RluA to one of its substrates, tRNA Phe anticodon stem-loop, induces reorganization of the RNA [21]. An ability of...

Ngày tải lên: 18/02/2014, 16:20

... ligand of ERs, does not bind to any members of the ERR fam- ily [14,19]. Likewise, BPA binds only weakly to ERs and does not bind at all to any other receptors of the ERR family. BPA has the ... the cells were trea- ted with a vehicle solution to measure the basal con- stitutive activity of each receptor, by using exactly the same of amount of expression pl...

Ngày tải lên: 18/02/2014, 16:20

... to the right and the addition of further residues at the N-terminus or beyond residue 34 of the inhibitory segment is superfluous. However, in the case of PpPr, the serendipitous positioning of ... polypeptide. The benefit of these alterations at each extremity of the polypeptide chain, must of necessity arise from contacts that are made outwith the active si...

Ngày tải lên: 19/02/2014, 00:20

... sensitive to the pres- ence of the anion. These residues also modulate the conformation of unfol- ded cytochrome c, influencing its spin state and the coordination to the prosthetic group. Abbreviation CT, ... is expected to be the best candidate for ligand X (the other likely candidates, i.e. the lysines, are fully proto- nated at pH 2.2) [18]. The heterogeneous c...

Ngày tải lên: 19/02/2014, 05:20

... the SP isoforms when the con- centrations of these isoforms was standardized to 1.0 mm. Significantly, the TH activity of the SP isoforms showed concentration dependence in the presence of 0.2 mm ... and lowers the energy barrier to allow adsorption of the ‘less active’ isoform; (b) the less active isoform (SP or QAE2) can then adsorb to the ‘open space’ betwe...

Ngày tải lên: 19/02/2014, 16:20

... in terms of the number of the enzymes involved, the kinetic mechanisms of the competing enzymes and the number as well as the nature of the allosteric controls. Whether such diversity in the organization ... distribution and to what extent changes in the concentration of the inhibitor P i alters the Phser flux partition. Due to the numerous interaction...

Ngày tải lên: 20/02/2014, 02:21