Báo cáo khoa học: Domains of ERRcthat mediate homodimerization and interaction with factors stimulating DNA binding potx

... (1994) Nuclear extracts enhance the interaction of fusion proteins containing the DNA- binding domain of the androgen and glucocorticoid receptor with andro- gen and glucocorticoid response elements. ... regulates androgen receptor transcriptional activity. J. Biol. Chem. 276, 46647–46654. Ó FEBS 2002 DNA binding of ERRc (Eur. J. Biochem. 269) 4097 Domains of ERRc tha...

Ngày tải lên: 31/03/2014, 09:20

... acidification of intracellular acidic organ- elles including endosomes, lysosomes, and phagosomes without perturbation of the formation of intracellular organelles and without alteration of the morphology of ... the morphology of vacuolar compartments, resulting in the profound inhibition of the endosomal ⁄ lysosomal degradation of macromolecules and targeting of lysoso...

Ngày tải lên: 16/03/2014, 14:20

... kinetic properties of NR1, and as we have shown for CPR and P450 BM3 (23,24,28) the properties of the flavin binding domains of NR1 are likely to mimic the redox properties of the domains in full-length ... transfer properties of the FAD- and FMN -binding domains of the human oxidoreductase NR1 Robert D. Finn 1 , Jaswir Basran 2 , Olivier Roitel 2 , C. Roland Wolf 1...

Ngày tải lên: 23/03/2014, 21:20

... membrane- and RNA- binding sites of Era overlap. To further understand the inhibition of liposome on the binding of Era to poly(U), we analyzed the effects of different component lipids of the liposome ... contains the RNA -binding domain (KH domain) and the region essential for the binding of Era to the cyto- plasmic membrane [20,24]. Ó FEBS 2003 16S rRNA- and membra...

Ngày tải lên: 31/03/2014, 07:20

... intermediates found here with the intermediates found during the refolding studies of HPI, a mixture of intermediates P3 and P4 captured during the refolding process were used as a marker. Intermediate ... native PAGE. Isolation and purification of the scrambled disulfide isomers of HPI In the presence of denaturant and thiol catalyst as indicated above, HPI was converted into...

Ngày tải lên: 19/02/2014, 12:20

... The relative abundance of ADH3 within many different tissue types is probably related to the need of scavenging formaldehyde for cytoprotection, but low activity of ADH3 with ethanol and retinol cannot ... Tomac, A.,Eriksson,U.,Perlmann,T.&Olson,L.(1999)Roleof retinoids in the CNS: differential expression of retinoid binding proteins and receptors and evidence for presenc...

Ngày tải lên: 21/02/2014, 00:20

... promote ornithine and SAH production, which in turn could be used for the formation of polyamines and methionine. An investigation of the level of different intermediate metabolites and the expression of different ... prominent up-regulation of the expression and enzymatic activity of both AGAT and GAMT. The specific activity of AGAT in sarcoma tissue reached almost 50%...

Ngày tải lên: 07/03/2014, 04:20

... levels observed with TNFa or fMLP alone (Fig. 2B,C) with > 90% of the [ 3 H]PtdBut accumulating within the first 5 min of stimulation. Effect of PI3-kinase and ARF inhibitors on O À 2 and PLD activation Selective ... 5B) with an approximate size of 120 kDa. Lysates of CHO cells transfected with human PLD1 were used as positive controls. The subcellular distribution o...

Ngày tải lên: 07/03/2014, 15:20

... namely C3 of Rha II ,C2ofRha III and Rha IV , and C2 and C3 of Rha I to d 78.5–79.1 (by 6–8 p.p.m.), and the similarity of the C2-C6 chemical shifts of the GlcNAc residue to those of nonsubstituted ... which consists of four residues of L -Rha and one residue of D -GlcNAc. A relatively large J 1,2 coupling constant value of 8 Hz for the H1 signal of the GlcNAc re...

Ngày tải lên: 08/03/2014, 08:20

... granules, and that it consists of a single component, the molecular mass of which is in the range of 43–45 kDa. Purification of the protein and subsequent clo- ning of its complementary DNA yielded ... a reamplification of an aliquot with 30 cycles and an annealing temperature of 55 °C. From the sequence of this PCR-fragment new primers were designed and used for the...

Ngày tải lên: 08/03/2014, 10:20