Báo cáo khoa học: Adaptability and flexibility of HIV-1 protease potx

... accurate Fig. 2. Basic structure of P2 analogues of cyclic urea inhibitors (A) and properties and structures of all inhibitors (B). Ó FEBS 2003 Adaptability and flexibility of HIV-1 protease (Eur. J. Biochem. ... flexi- bility and adaptability of proteins in general. Keywords: adaptability; flexibility; HIV-1 protease; inhibi- tors; structure. The significance...

Ngày tải lên: 31/03/2014, 07:20

... with binding of both MOF and Tip60 (equivalent to Esa1 in yeast NuA4) [124,130]. However, in human cells depletion of MOF, but not Tip60, results in reduced global levels of AcH4-K16 and defective ... acetylation and deacetyla- tion, and transient recruitment of remodellers and transcription factors. A cycle of transcription commences with the recruit- ment of transcript...

Ngày tải lên: 14/02/2014, 18:20

... Scientific Fund of the Ministry of Education, Science and Culture of Japan (G.T.); the Program for Promotion of Fundamental Studies in Health Sciences of the National Institute of Biomedical Innovation Table ... tumors and cell lines, miR-17- 5p and miR-20a are induced in a manner that depends on cyclin D1 and repress the expression of cyclin D1. Hence, miR-17-5p ⁄ 20a a...

Ngày tải lên: 14/02/2014, 19:20

... in order to secrete IL-1b and TNF-a. Hypoxia ⁄ SD induces the transcription and secretion of IL-10 Because of the lack of secretion of the inflammatory cytokines IL-1b and TNF-a from hypoxia ⁄ ... presence and absence of IL-10. *P < 0.05 and **P < 0.01 versus Cont group. (D) Representative western blots for collagen I and III in the presence and absence of 0.1 l...

Ngày tải lên: 18/02/2014, 04:20

... advantage of p53 mutation analysis, and a unique feature of this database, is the availabil- ity of the residual activity of the majority of p53 mis- sense mutants. The biological activity of mutant ... core domain of the protein and were used for training and evalua- tion of our prediction algorithm. Of the eight promoters, we studied the WAF1 promoter in greatest det...

Ngày tải lên: 18/02/2014, 11:20

... M r values of the standards in thousands. Lanes 2–9, 5 lg of peak P I, P II, P III ⁄ P IV and a mixture of other isoforms (*), respec- tively, in the presence (lanes 2–5) or absence (lanes 6–9) of 2-mercaptoethanol. ... similarity of the A- and B-chains of the four isoforms, a pairwise alignment was performed and the values of identity expressed in Fig. 3. (Continued). Cha...

Ngày tải lên: 18/02/2014, 16:20

... Functional Analyses from the Ministry of Education, Culture, Sports, Science and Technology of Japan, and CREST and BIRD projects of JST (Japan Science and Technology Agency). References 1 Segal ... extent of membrane localization of Noxo1b and Noxo1c. The intensities of immunoreactive bands for HA-Noxo1b and HA-Noxo1c in (B) were quantified using a LAS-1000plus (Fuji fi...

Ngày tải lên: 19/02/2014, 06:20

... Buchert 1 and Kristiina Kruus 1 1 VTT Technical Research Centre of Finland, Espoo, Finland 2 Protein Chemistry Research Group and Core Facility, Institute of Biotechnology, University of Helsinki, ... Foundation of Raisiogroup (Raisio, Fin- land), the Finnish Funding Agency for Technology and Innovation (TEKES) and the Commission of the Euro- pean Communities, specifically RT...

Ngày tải lên: 19/02/2014, 06:20

... 7A, D, I and L are diamidino-2phenylindole hydrochloride (DAPI) stained cells showing the nuc- leus, and Fig. 7C, F, K and N are the merged images of A and B, D and E, I and J, and L and M, respect- ively. Discussion Nature ... stresses used for treatment of pea seedlings were cold (A and B), salinity (C and D), wounding (E and F), drought (G and H), SA (I and J)...

Ngày tải lên: 19/02/2014, 07:20

... evidence for existence of two distinct HSF1 isoforms in rainbow trout and the formation of heterotrimers of these isoforms in vitro. Materials and methods Cell culture and animals Rainbow trout ... 10.0; GAPEXT ,0.05; GAPDIST ,8; MAXDIV , 40; ENDGAPS ,off; NOPGAPS ,off; NOHGAPS ,off.Graphical output of the bootstrap figure was produced by the program TREEVIEW . Isolation of RNA...

Ngày tải lên: 19/02/2014, 12:20