Báo cáo khoa học: Kininogen-derived peptides for investigating the putative vasoactive properties of human cathepsins K and L docx

... tissue (glandular) kallikrein forms kallidin from low- and high-molecular weight kininogens (LMWK/HMWK). Their amount is regulated by kininases, which rapidly breakdown kinins to give peptidyl fragments, some ... ratio, 1); lane 7, cathepsin L/ HMWK (molar ratio, 0.25); lane 8, cathepsin L. Fig. 2. Hydrolysis of kininogen-derived peptides and kinins by hK1 and cathepsins B,...

Ngày tải lên: 31/03/2014, 07:20

... layer of complexity to both the regulation of chlorophyll biosynthesis, and the availability of MgP for signalling to the nucleus. We suggest that the relative amounts of both Gun4 and CHLH are ... the methyltransferase and mag- nesium chelatase are likely to be crucial in determining the availability of MgP for both signalling [20] and biosynthetic roles in...

Ngày tải lên: 20/02/2014, 02:21

... than the yield of Lys33GP. The molecular mass of Lys3 3K ⁄ F was determined to be 3722.0 Da, which is identical to the theoretical value (Table 1). Chemical synthesis of the core peptide Lys16 To ... theoretical value (Table 1). Inhibition kinetic analysis of Lys33GP, Lys3 3K ⁄ F, and Lys16 peptide The inhibition kinetics of the native MBTI, Lys33GP, Lys3 3K ⁄F and...

Ngày tải lên: 15/03/2014, 09:20

... nugget precision and nugget recall, where re- call is heavily favored (controlled by the β parame- ter, usually set to three). Nugget recall is calculated solely on vital nuggets, while nugget precision ... or multiple nuggets. The final F-score for an answer is calculated in the manner described in Figure 1, and the final score of a run is the average across the F-scores o...

Ngày tải lên: 20/02/2014, 12:20

... computer and key- board in the English Wikipedia. provides multilingual support for the English, Ger- man, French and Italian Wikipedias and can be eas- ily extended to other languages 4 . 4 Software ... believe that the extensive usage of such measures derives also from the availability of robust and freely avail- able software that allows to compute them (Pedersen et a...

Ngày tải lên: 20/02/2014, 12:20

... [48]. The hydrophilicity, lack of structure and associated flexibil- ity are essential for the solubilizing role of the exten- sion in the sHsp and complexation of the sHsp with target proteins. The ... between the molecular weight markers thyro- globulin (mass of 669 kDa) and apoferritin (mass of 443 kDa) (Fig. 4), with an average molecular mass of 613 ± 185...

Ngày tải lên: 07/03/2014, 04:20

... continuously. It offers the public, the media, politicians and scholars a new and timely perspective on the dynamics of the electoral process and public opinion. 1 Introduction Social media platforms ... as well as some random neutral tweets. It also shows the total volume over time and a tag cloud of the most frequent words in the last five minutes across al...

Ngày tải lên: 16/03/2014, 20:20

... collec- tions of ASRs cover only a very limited fraction of the proteome and are unlikely to be available for most metabolites or drugs. Labeling query molecules for large scale studies can often ... [1–7]. Understanding the dynamic nature of these inter- actions will reveal the functional responsibilities of proteins and the circuits in which they operate [8]. The c...

Ngày tải lên: 23/03/2014, 15:21

... novel steroid hormone and the adrenal gland the major place of synthesis of ouabain. However, it is still much debated whether ouabain or OLF really exist in mammalian blood and tissues, and if they ... doi:10.1046/j.1432-1033.2003.03554.x hypothetical cascade of events initiated by ouabain occu- pancy of a small fraction of the sodium pumps. One of them had advocated...

Ngày tải lên: 23/03/2014, 17:21

... true of unions of elements of the semilattice). These predicates are not only true of the conventional kinds but also of conventional servings such as the bottle of wine on the table or the ... true of individual men and of kinds of men. The s-theory rather has a lexical. extension rule which will convert the lexical count noun man into one which is a m...

Ngày tải lên: 24/03/2014, 01:21