Báo cáo khoa học: Regulation of STAT signalling by proteolytic processing Lisa Hendry and Susan John doc

... MINIREVIEW Regulation of STAT signalling by proteolytic processing Lisa Hendry and Susan John Peter Gorer Department of Immunobiology, Programme in Infection and Immunity, King’s College ... cells. Proteolytic regulation of Stat5 and Stat3 in mature human neutrophils Stat3 and Stat5 isoforms have been identified in differen- tiated human peripheral bl...

Ngày tải lên: 30/03/2014, 15:20

... Canadian Institutes of Health Research and CANVAC, the Canadian Network for Vaccines and Immunotherapeutics. N.G. was supported by a post- doctoral FRSQ fellowship, J.Ha. and B.R.T. by an NSERC studentship, ... Activation of p38 mitogen-activated protein kinase and c-Jun NH(2)-terminal kinase by double- stranded RNA and encephalomyocarditis virus: involve- ment of RNase...

Ngày tải lên: 07/03/2014, 21:20

... expression of the INO1 gene (and low levels of PtdCho turnover). Thus, high steady-state levels of P A correlate with th e inability of the INO1 gene to repress in response to inositol availability, and ... steady-state levels o f phospholipids using 32 P-labelling, showed that deregulation of the INO1 gene correlates with higher s teady-state levels of PA (Fig. 6). The steady-...

Ngày tải lên: 30/03/2014, 15:20

... recruitment by DNA-bound SRF of an, as yet, unidentified accessory factor [54]. The regulation of c-jun is complex and may involve an increase in the levels of c-jun protein and/ or phosphorylation of specific ... between the CBP and AP-1 components, c-fos and c-jun, was previously reported [42,43]. Meanwhile, CREB’s serine 133 phosphorylation state is determined by the lev...

Ngày tải lên: 08/03/2014, 08:20

... to the nucleus and suppressed transcriptional activity of As-rel1, possibly because the level of activity of a heterodimer of As-rel1 and As-rel2 is lower than that of a homodimer of As-rel1. On ... repre- sentation of the structures of the As-rel genome and mRNAs of As-rel1 and As-rel2. (B) Genome sequence of splicing sites. Note that As-rel1 mRNA is generated by...

Ngày tải lên: 30/03/2014, 20:20

... Deletion of CLA4 results in higher amounts of SE. (A) Quan- tification of SE in cell polarity mutants. Cells of the indicated strains were grown to stationary phase and then lipids were extracted and separated ... 6A). Expression of either STE20 or CLA4 from multicopy plasmids did not alter the levels of SE (Fig. 6B). A higher concentration of SE in cla4D cells could be expla...

Ngày tải lên: 18/02/2014, 13:20

... instead of Azo (Fig. 1). Clear-cut on–off photoregulation of DNA transcription was obtained because of the efficient suppression of T7 RNA polymerase (RNAP) binding to the DM-azo in the trans form. By ... [ 32 P]ATP[aP]) and the photoregulatory efficiency of transcription (a) was Fig. 1. Sequences of photoresponsive T7 promoters and the structures of Azo and its derivative...

Ngày tải lên: 15/03/2014, 10:20

... of an isoform of PP1, PP1a [3]. Similarly, activation of caspase-8 and -3 is regulated through their phosphorylation and dephosphorylation. Phosphorylation of caspase-8 at Tyr397 and Tyr465 by Lyn, ... phosphorylation of 14-3-3 at Ser184; this reduces the affinity of 14-3-3 for Bax and Bad and translocation of Bax and Bad to mitochon- dria independently of caspase...

Ngày tải lên: 14/02/2014, 22:20

... involved in the regulation of life span and progression of cancer and they are also important for developmental processes such as gametogenesis, neurogenesis and mainte- nance of sensory organs. ... surfaces of unfolded proteins, thereby facilitating refolding of pep- tides and preventing protein aggregation [32]. The dis- covery of an interaction between HSF1 and HSPs...

Ngày tải lên: 18/02/2014, 04:20

... the binding of substrates and other inhibitors and to iden- tify the mechanism by which it regulates the activity of cathepsin B. Results Preparation and characterization of 2A2 mAb and its Fab ... concentration of 2A2 mAb at a fixed molar ratio of cathepsin B and cystatin C resulted in weaker bands of the cathepsin B ⁄ cystatin C complex and stronger bands correspond...

Ngày tải lên: 18/02/2014, 11:20