Báo cáo khoa học: Reformable intramolecular cross-linking of the N-terminal domain of heparin cofactor II pptx

Báo cáo khoa học: Reformable intramolecular cross-linking of the N-terminal domain of heparin cofactor II pptx

Báo cáo khoa học: Reformable intramolecular cross-linking of the N-terminal domain of heparin cofactor II pptx

... linkage of the N terminus to the serpin core of HCII re sulted in a maximal 2.1-fold reductio n of the Table 2. Cyanogen bromide (CNBr) cleavage fragments of heparin cofactor II (HCII). Formationofanintramoleculardisulfidebetween the ... Reformable intramolecular cross-linking of the N-terminal domain of heparin cofactor II Effects on enzyme inhibiti...

Ngày tải lên: 30/03/2014, 15:20

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Tài liệu Báo cáo khoa học: Stefin A displaces the occluding loop of cathepsin B only by as much as required to bind to the active site cleft doc

Tài liệu Báo cáo khoa học: Stefin A displaces the occluding loop of cathepsin B only by as much as required to bind to the active site cleft doc

... A comparison of the structure of the unli- ganded cathepsin B with the structure of the proenzyme, its complexes with chagasin and stefin A shows that the magnitude of the shift of the occlud- ing ... 1) between stefin A and the different enzymes is the average distance between the centre of mass of CA atoms of the stefin molecule and the centre of mass...

Ngày tải lên: 18/02/2014, 04:20

8 633 0
Tài liệu Báo cáo khoa học: Branched N-glycans regulate the biological functions of integrins and cadherins doc

Tài liệu Báo cáo khoa học: Branched N-glycans regulate the biological functions of integrins and cadherins doc

... regula- tion of the conformation of integrin, determine the extent of cell migration. The mutual regulation of GnT-III and E-cadherin To a certain degree, mutual regulation of GnT-III expression ... modified by either GnT-III or GnT-V (Fig. 2). This finding shows that GnT-III inhibits GnT-V-stimulated a 3 b 1 -mediated cell migration. The priority of GnT-III for modification...

Ngày tải lên: 18/02/2014, 17:20

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Tài liệu Báo cáo khoa học: Bone morphogenetic proteins in the early development of zebrafish pptx

Tài liệu Báo cáo khoa học: Bone morphogenetic proteins in the early development of zebrafish pptx

... transmembrane domain. Bind- ing of the ligand to the receptor complex induces the type II receptor to phosphorylate the type I receptor, which then leads to activation of the type I receptor. The signal ... change the preference of site utilization; and (c) promotion of the dissociation of Chordin cysteine-rich (CR)-containing fragments from the ligand. They sug...

Ngày tải lên: 19/02/2014, 00:20

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Tài liệu Báo cáo khoa học: Rotary F1-ATPase Is the C-terminus of subunit c fixed or mobile? docx

Tài liệu Báo cáo khoa học: Rotary F1-ATPase Is the C-terminus of subunit c fixed or mobile? docx

... torque of 112 pNÆnm, the arrows show the beginning (t ¼ 1ns)andtheend(t¼ 23 ns) of the forced rotation. With 56 pNÆnm torque, the relaxation of the system was calculated during the last 8 ns of the ... the C-terminal portion of c, thus allowing for unimpaired rotation of the remainder of c.Furthermore, the calculations suggested the very end of c to be cl...

Ngày tải lên: 19/02/2014, 16:20

9 547 0
Tài liệu Báo cáo khoa học: A point mutation in the ATP synthase of Rhodobacter capsulatus results in differential contributions of DpH and Du in driving the ATP synthesis reaction pptx

Tài liệu Báo cáo khoa học: A point mutation in the ATP synthase of Rhodobacter capsulatus results in differential contributions of DpH and Du in driving the ATP synthesis reaction pptx

... in the absence of a Du,as shown in Fig. 3 C. In the presence of a Du, the difference between the two strains was twofold over the entire DpH range tested. In the absence of a Du, the ATP synthesis ... including the f act that in the ATP synthases of mitochondria and of photosynthetic bacteria the position of these two amino acids in the primary sequence are i...

Ngày tải lên: 21/02/2014, 03:20

9 580 0
Tài liệu Báo cáo khoa học: Unfolding and aggregation during the thermal denaturation of streptokinase pptx

Tài liệu Báo cáo khoa học: Unfolding and aggregation during the thermal denaturation of streptokinase pptx

... over the unfolding transition of SK domain A. The enthalpy of the aggregate per mol of monomer unit (177 kJÆmol )1 ) lies between the enthalpies of the native state (the reference state) and the ... low unfolding enthalpy of the domain, is consistent with its lower degree of structure [5]. Under the same equilibrium conditions, the values of T m and DH m fo...

Ngày tải lên: 21/02/2014, 03:20

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Báo cáo khoa học: Human telomeric G-quadruplex: The current status of telomeric G-quadruplexes as therapeutic targets in human cancer pdf

Báo cáo khoa học: Human telomeric G-quadruplex: The current status of telomeric G-quadruplexes as therapeutic targets in human cancer pdf

... which indicate that the approach may be applicable to the treatment of a wide range of human cancers. This minireview summarizes the available data on these compounds and the challenges posed ... representative of the totality of the single-stranded overhang, and which may be important for these ligands being able to differentiate telomeric quadruplexes from others in the...

Ngày tải lên: 06/03/2014, 09:22

8 446 1
Báo cáo khoa học: Trigger factor interacts with the signal peptide of nascent Tat substrates but does not play a critical role in Tat-mediated export pptx

Báo cáo khoa học: Trigger factor interacts with the signal peptide of nascent Tat substrates but does not play a critical role in Tat-mediated export pptx

... accele rated in the absence of TF probably by the disclosure of a more direct cotranslational targeting pathway to the Sec translocon [3]. Perhaps, the proofreading activity of the Sec t ranslocase ... To investigate whether this interaction is functionally relevant for the export of Tat p roteins, we monitored the effect of the intracellular TF level on the efficie...

Ngày tải lên: 07/03/2014, 16:20

9 393 0
Báo cáo khoa học: "A Formula Finder for the Automatic Synthesis of Translation Algorithms" docx

Báo cáo khoa học: "A Formula Finder for the Automatic Synthesis of Translation Algorithms" docx

... encountered, the program specifies the truth values of the variables in D r for the given values of i and j. The program then evaluates the truth value of D r in terms of the truth values of the ... translated of the oscilla- tions of the voltage of the trigger . . . rather than by the smoother inverted construction . . . of the oscilla- tion...

Ngày tải lên: 16/03/2014, 19:20

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