Báo cáo khoa học: Fibroblast growth-stimulating activity of S100A9 (MRP-14) ppt

... Discussion Inhibition of proteases by MA It has been previously proposed that MA may inhibit the activity of proteases of T. gondii [14] and HIV [12,31]. To ascertain the inhibition range of MA on the ... the drug. Effect of MA on the activity of P. falciparum MSP As shown in Table 1, MA inhibits subtilisin with an IC 50 in the range of 50 lm. Subtilisin is a serine prote- a...

Ngày tải lên: 14/02/2014, 14:20

... of the two distinct functions of TorD with the folding of TorA and possible interactions of both proteins with the MGD biosynthetic apparatus [12]. The concentration of GTP in the cytoplasm of ... hydrolytic activity towards ATP (Fig. 1A). The binding of a magnesium cofactor has long been established as essential for the activity of canonical GTP-binding proteins [29,31]....

Ngày tải lên: 16/02/2014, 09:20

... recognition of p NPP by the pNPP site at t he rear su rface of the N -domain is due the formation of an hydrogen bond of the NO 2 -group of pNPP with the amino group of N398. The hydrophobicity of the ... optimized. Results Effects of truncation of the cytoplasmic H 4 -H 5 loop of the a subunit of Na + /K + ATPase on TNP-ATP binding and p -nitrophenylphosphatase activit...

Ngày tải lên: 19/02/2014, 16:20

... Antibacterial activity of LK peptides (Eur. J. Biochem. 270) 2217 The antibiotic activity of cationic linear amphipathic peptides: lessons from the action of leucine/lysine copolymers on bacteria of the ... action of these peptides comprises four main steps: step 1, interfacial partitioning and exofacial accumulation of Fig. 5. Graphical illustration of the effects on antibac...

Ngày tải lên: 23/03/2014, 17:21

... of Ionic Channels of Cell Membranes, Institute of Cytology of RAS, St Petersburg, Russia 2 Division of Molecular and Radiation Biophysics, Petersburg Nuclear Physics Institute of RAS, Gatchina, ... point of the I–V plot represents the mean ± SD of at least ten current readings. The line shows a linear regression fit of the data points. O. S. Ostroumova et al. Ion channel act...

Ngày tải lên: 28/03/2014, 23:20

... significance of enzyme–substrate contacts for catalysis. This study highlights the importance of the interaction of a phosphoserine of the RS domain of the substrate with the catalytic region of the ... enzymatic activity of the nuclear matrix- localized SRPK1 is repressed. These results suggest a new role for SAFB proteins as regulators of SRPK activity and underline the i...

Ngày tải lên: 30/03/2014, 01:20

... Photon Source, Argon- ne National Laboratory. Use of the Advanced Photon Source was supported by the U. S. Department of Energy, Of ce of Science, Of ce of Basic Energy Sci- ences, under Contract No. ... black. (C) Stereoview of the alignment of the active sites of AfRio1 (green) and AfRio2 (orange; PDB code 1ZAO). (D) Stereoview of the alignment of the active sites and bo...

Ngày tải lên: 30/03/2014, 20:20

... expression of miR-21 is increased selectively in fibroblasts of the failing heart, which augments ERK⁄ MAPK activity through the inhibition of sprouty homolog 1, a negative regulator of MAPK [15]. ... the fine-tuning of p53 activity [45,46]. miR-34a is also induced by a p53-independent pathway: ELK1, which is a member of the ETS family of transcription factors, mediates the in...

Ngày tải lên: 14/02/2014, 19:20

... Thompson (1988). One of the conjectures of VT is that the vein expression of a unit (terminal node), which includes a chain of discourse units that contain that unit itself, provides an “abstract” or summary of ... referential expressions in a corpus of texts C using DRAs of size k is computed as the sum of the efforts e(M,a,DRA k ) of all referential expressions a where VT...

Ngày tải lên: 20/02/2014, 18:20

... sequence of spectra, the relation between the meaning of a sentence and the sequence of words is not a simple linear sequential model. Language is inherently nested, with subgroups of concepts ... and (2) the sets of terminal and nonterminal nodes must remain disjoint. Both of these requirements can be satisfied by trees possessing most of the structural characteristics of...

Ngày tải lên: 08/03/2014, 07:20