Báo cáo khoa học: Sugar and alcohol molecules provide a therapeutic strategy for the serpinopathies that cause dementia and cirrhosis pot

... 2006 The Authors Journal compilation ª 2006 FEBS Sugar and alcohol molecules provide a therapeutic strategy for the serpinopathies that cause dementia and cirrhosis Lynda K. Sharp 1, *, Meera Mallya 1, *, ... Miranda E, Ro ¨ misch K & Lomas DA (2004) Mutants of neuroserpin that cause dementia accumulate as poly- A therapeutic strategy for t...

Ngày tải lên: 30/03/2014, 11:20

... of the type o f Graph 1 (these paths may contain parallel and antiparallel arrows). The sign of that element therefore depends on the both the sign and the magnitudes of these influen ce paths ... s ubstance on the right i s a substrate o f the reaction. Then the a rrow points b ackward, i.e. a way from t he substance and there is a right-hand factor – a equal...

Ngày tải lên: 19/02/2014, 16:20

... the enzymeÆreactivase complex was formed in small amounts from apoenzyme and the reactivase and not at all from the enzymeÆCN-Cbl complex and the reactivase (data not shown). Affinity of the reactivase for ... contrast, a peak of the free reactivase decreased and a new peak appeared in the presence of ADP. The latter peak was eluted with a Table 2. Nucleotide a...

Ngày tải lên: 15/02/2014, 01:20

... with salient properties Adj A 1 and Adj A 2 respec- tively, such that Adj A 1 and Adj A 2 are mutu- ally reinforcing. The combination is indexed on Adj A 1 +Adj A2 . Example: “as dark and sophisticated ... instances of the patterns “as ADJ and * as” and “as * and ADJ as” from Google, noting the combinations that are found and their frequencies. These freq...

Ngày tải lên: 20/02/2014, 05:20

... estimates and typicality values for the dative and benefactive alternation to produce a novel form (Briscoe and Copestake, 1996). 6 Typicality Estimating the productivity of an alternation for ... class for a given alter- nation. The underlying assumption is that a verb is typical for an alternation if it is equally frequent for both frames which are chara...

Ngày tải lên: 20/02/2014, 19:20

... mammalian cells. Both catalyse the exchange of mitochondrial ATP for cytosolic ADP, thereby playing key roles in maintaining the cytosolic phosphory- lation potential, adenylate charge, and the ... were separated on 4% nondenaturing polyacrylamide gel. The gels were dried and autoradiographed. Competitor DNAs used in EMSA analysis were: NF1 wt, 5¢-TTTTG GATTGAAGCCAATATGATA-3¢;NF...

Ngày tải lên: 07/03/2014, 15:20

... grammar lattice. All grammars generate , and only generates ( is a common lexicon for all the grammars) 3 A Grammar Lattice as a Search Space for Grammar Induction In this section we present a ... molecules . 3 The language of a grammar is the set of all syntagmas generated from the start symbol , i.e., . The set of all syntagmas generated by a grammar is . Given...

Ngày tải lên: 08/03/2014, 02:21

... handling uses the FUF formalism and the same ratification machinery as the grammar. formation like (potential) accent and syllable boundary positions. Input to the synthesizer is a SAMPA ... provided as well. Compared to text-to-speech the task is at the same time easier and more difficult. In- formation from pragmatic, semantic and syn- tactic layers are readily...

Ngày tải lên: 08/03/2014, 06:20

... including straight- and branched-chain FAs, as well as mono- and polyunsaturated FAs. There is one exception, however, and that is if the carbon-3 has a methyl- or any other functional group attached. ... blindness with anosmia, cerebellar ataxia and a range of other more variable abnormali- ties. The only therapy available to date is a life-long diet low in phytanic acid,...

Ngày tải lên: 22/03/2014, 16:21

... effect (for those that modify the gating mechanism) and Cn11 (a blocking toxin). We expect that, when more data become available, the concepts on the interaction of Na-ScTxs and Na + channels ... whereas small contaminants (5%) were eliminated on the ascending and descending sections of the chromatogram. (B) Direct Edman degrada- tion of native peptide and reduced and...

Ngày tải lên: 23/03/2014, 12:20