Báo cáo khoa học: Structure–activity relationships of fowlicidin-1, a cathelicidin antimicrobial peptide in chicken docx

Tài liệu Báo cáo khoa học: Structure-activity relationships of a-conotoxins targeting neuronal nicotinic acetylcholine receptors ppt

... Mutational analyses havealso been valuable in elucidating factors important foractivity. Table 2 lists the most informative mutations thathave been made in a range of a- conotoxins. In addition,an ... University of Queensland, Brisbane, QLD, Australia a- Conotoxins that target the neuronal nicotinic acetylcho-line receptor have a range of potential therapeutic applica-tions and are valuable probes ... uncommon feature of an arginine residue atposition 12 (Table 1) appears to contribute to a4 b2anda7subtype activity but not a3 b2 activity. A decrease in a4 b2and a7 subtype activity but not a3 b2 activity...

Báo cáo khoa học: Structure–activity relationships of fowlicidin-1, a cathelicidin antimicrobial peptide in chicken docx

... mature fowlicidin-1, a linear peptide of 26 amino acid residues, was found tobe broadly active against a range of Gram-negativeand Gram-positive bacteria with a potency similar tothat of SMAP-29 ... 2534–2539.40 Tossi A, Scocchi M, Skerlavaj B & Gennaro R (1994)Identiﬁcation and characterization of a primary antibac-terial domain in CAP18, a lipopolysaccharide bindingprotein from rabbit leukocytes. ... relationships of fowlicidin-1, a cathelicidin antimicrobial peptide in chicken Yanjing Xiao1,*, Huaien Dai2,*, Yugendar R. Bommineni1, Jose L. Soulages3, Yu-Xi Gong2,Om Prakash2and...

Báo cáo khoa học: Structure ⁄function analysis of spinalin, a spine protein of Hydra nematocysts doc

... Golgi apparatus.During this process, the external tubule is assembled atthe apical end of the capsule and in a later stage invag-inates into the capsule matrix and spines are assembled in the ... mm NaCl. SDS ⁄ PAGE in the absence of a reducing agent showed that the spinalin of the ﬁrstpeak migrates as a double band in the gel, with oneband running at a similar position to spinalin in ... is dramatically decreased during capsule matur-ation [3].Expression and oligomerization of spinalin A cDNA coding for full-length spinalin including thesignal peptide was produced by PCR ampliﬁcation,and...

Báo cáo khoa học: Structure and function of human a-lactalbumin made lethal to tumor cells (HAMLET)-type complexes pptx

... route of functional diversiﬁcation of proteins via varying their conformational states and associated ligands.AbbreviationsANS, 8-anilinonaphthalene-1-sulfonic acid; BAMLET, bovine a- lactalbumin ... that a- lactalbumin in the MAL fraction wasstructurally modiﬁed. As no post-translational modiﬁ-cations were detected, the folding state of a- lactalbu-min in MAL was examined with CD and binding ... dis-tinct conformational states. On the basis of these data, a putative binding site of the C18:1 fatty acid was pro-posed to involve the b-sheet domain of a- lactalbumin.Similar to human a- lactalbumins...

Báo cáo khoa học: " Improved Automatic Detection of Zero Subjects and Impersonal Constructions in Spanish" docx

... Evans. 2001. Applying machine learning: towardan automatic classiﬁcation of it. Literary and Lin-guistic Computing, 16(1):45–57. A. Ferr´andez and J. Peral. 2000. A computational ap-proach ... Computational Linguistics(COLING-02), pages 1–7.Real Academia Espa˜nola. 2001. Diccionario de lalengua espa˜nola. Espasa-Calpe, Madrid, 22 edi-tion.Real Academia Espa˜nola. 2009. Nueva ... presence or absence of a sub-ject in the clause, as identiﬁed by the parser.We are not aware of a formal evaluation of Connexor’s accuracy. It presents an accu-racy of 74.9% evaluated against our...

Tài liệu Báo cáo khoa học: Structure and function of active chromatin and DNase I hypersensitive sites pdf

... If a similar mechanism operates in mammalian cells, then KDM 2A may suppress thispathway and maintain histone acetylation at tran-scribed CG islands.It is becoming increasingly likely that ... bindingsites accessible [204].CG islands maintain active chromatin domainsfree of DNA methylationDNA methylation is one of the most prevalent mecha-nisms employed within the genome to maintain inac-tive ... Drosophila, speciﬁcacetylation of H4-K16 is an integral feature of dosagecompensation that results in a global two-fold increase in gene activity [126]. Interestingly, AcH4-K16 playsan additional...

Tài liệu Báo cáo khoa học: Salt-induced formation of the A-state of ferricytochrome c – effect of the anion charge on protein structure docx

... 5349by following the changes in the 695 nm absorbanceband. It appears clear that both anions favor proteincollapse into a compact form, and induce formation of a consistent population of macromolecules ... the K88E mutation introduces an acidic resi-due (E88, present in yeast [28]) in place of a lysine,whereas in site 2, the K13N mutation introduces anasparagine in place of a lysine. This provides ... encompassing residuesK86, K87, and K13, located at the interface betweenthe N-terminal and the C-terminal a- helices, indicatedFig. 5. Thermal stability of the A- state of cytochrome c as a func-tion...

Tài liệu Báo cáo khoa học: Structure and function of plant aspartic proteinases pptx

... protein family includessaposins, which are lysosomal sphingolipid-activator pro-teins [37], NK-lysin, granulysin, surfactant protein B,amoebapores and domains of acid sphingomyelinase andacyloxyacyl ... hydrophobicN-terminal signal sequence, responsible for translocationinto the ER, followed by a prosegment of about 40 aminoacids, and a N-terminal domain and a C-terminal domainseparated by an insertion ... Molecular and biochemical characterisation of two asparticproteinases TcAP1 and TcAP2 from Theobroma cacao seeds.Planta 215, 754–762.12. Park, H., Yamanaka, N., Mikkonen, A. , Kusakabe, I. &Kobayashi,...

Báo cáo khoa học: Structure and function of KH domains docx

... The tandem KH1–KH2 domains of NusA recognizeRNA ligand 5¢-GAACUCAAUAG. (A) The KH1–KH2 domains of NusA bound to cognate RNA ligand (Protein Data Bank entry 2ASB). TheRNA–protein contact surface ... UACUAAC in pre-mRNA transcripts[35], with KH domain binding augmented by addi-tional interactions with an N-terminal helix known asthe QUA2 domain (labeled in Fig. 7) [36]. The RNAadopts an ... complex.Nucleic acid base-to-protein aromatic side-chain stack-ing interactions, which are prevalent in other types of single-stranded nucleic acid binding motifs [19,20], arenotably absent in KH domain...

Báo cáo khoa học: Structure and mechanism of the ThDP-dependent benzaldehyde lyase from Pseudomonas ﬂuorescens potx

... lyase (BAL) catalyzes cleavage and formation of R-benzoin. BAL is known to accept several other substituted aro-matic or aliphatic acyl-acceptors as substrates for the formation of an acyloin ... ﬂanked by a varyingnumber of a- helices. Residues involved in binding of the cofactor ThDP are located at the C-terminal ends of the b-strands of Dom-c (diphosphates and Mg2+)and of Dom -a ... andcatalyse a broad range of reactions mainly involvingthe cleavage and the formation of C–C-bonds. Forinstance, they catalyse nonoxidative and oxidative de-carboxylations of 2-ketoacids, produce...

Xem thêm