Báo cáo khoa học: The subcellular localization of vaccinia-related kinase-2 (VRK2) isoforms determines their different effect on p53 stability in tumour cell lines pdf

... 2006 The Authors Journal compilation ª 2006 FEBS The subcellular localization of vaccinia-related kinase-2 (VRK2) isoforms determines their different effect on p53 stability in tumour cell lines Sandra ... isoforms have a different subcellular localization To identify and confirm the subcellular localization of both VRK2 isoforms the...

Ngày tải lên: 30/03/2014, 11:20

... enzyme. The protein subcellular localization is indicated next to the enzyme name using grey shading of the compartment within the symbolized cells. The presence of a question mark indicates contradictory ... interactions. (D) Test of b-galactosidase activity allowing the confirmation of protein interactions and the evaluation of the strength of protein interact...

Ngày tải lên: 15/03/2014, 00:20

... specificity of ADH4 for the oxidation direction, in the interconversion of 11-cis- retinoids. Localization of ADH4 in retina ADH4 has been immunolocalized in rat eye sections, using mouse-ADH4 polyclonal ... suggesting that the distinct location of the substrate in the binding pocket of ADH4 is the reason for the low activity observed with this retinal isomer....

Ngày tải lên: 23/03/2014, 12:20

... obtain CXRs after insertion of endotra- cheal tubes, intravenous lines and chest drains, but not after insertion of nasogastric tubes. In addition, CXRs were obtained in the case of worsening of ... infiltrates on the CXR; repositioning of tubes in case of malposition of orotracheal tubes (ignoring planned extuba- tions); ultrasound of the thorax in case of...

Ngày tải lên: 25/10/2012, 10:39

... In another report, depletion of Lin-9, Lin-37, Lin-52 or Lin-54 by RNAi also led to a repression of genes, such as cyclin A and cyclin B1, in dividing cells [92]. Furthermore, depletion of Lin-9 ... protected in G 0 cells. The Cdc25C gene is not expressed in resting cells or in cells in G 1 phase. Only in G 2 phase can strong transcription of the gene be detected. Mu...

Ngày tải lên: 16/02/2014, 09:20

... represented. The interfacial residues are color- coded according to the effect on CTD dimerization of removing the interactions of the side chain beyond the Cb (by mutation to ala- nine). The effect ... residues in the 3 10 -helix of one monomer and residues in helices 9 and 10 of the other monomer. No MHR residues are involved. The structural description...

Ngày tải lên: 18/02/2014, 06:20

... by peptides Protein assembly processes can be considered as good targets for antivirals because they depend only on recur- ring weak interprotein interactions, and the disruption of only a few of these interactions ... particle assembly in vitro and budding of immature-like capsids. The results obtained by Bartonova et al. [30] pinpoint an indirect (allosteric) effect of CAI...

Ngày tải lên: 18/02/2014, 06:20

... leads to induction of AP. Effects of BMP-2 (A) and proBMP-2 (B) on the induction of alkaline phos- phatase in C2C12 cells. AP activity was measured by determination of the change in extinction (DE) ... a displacement, induced by noggin. In addition to the potential physiological implica- tions of our findings, the interaction of proBMP-2 with BMPR-IA and noggin allo...

Ngày tải lên: 18/02/2014, 06:20

... upregulation in the liver of streptozotocin-induced diabetic rats and the suppres- sion of such elevation following insulin injection [21,22], we decided to investigate the effect of N H CH 2 CH COOH NH 2 L-kynurenine CHO COOH COOH NH 2 Tryptophan α-amino-β-carboxymuconate-ε-semialdehyde ... conformations of the Trp–Met couple can be observed; the arrows indicate the u...

Ngày tải lên: 18/02/2014, 06:20

... polymorph a-chitin (antiparallel packing of the chitin chains); b-chitin (parallel packing of the chitin chains); and the minor polymorph c-chitin (mixture of parallel and antiparallel chain packing) [1,2]. ... putatively encoding these proteins occur in many microorganisms. To obtain an impression of the functional conservation of these proteins, we studied the chitinol...

Ngày tải lên: 18/02/2014, 08:20