Báo cáo khoa học: Increased sensitivity of glycogen synthesis to phosphorylase-a and impaired expression of the glycogen-targeting protein R6 in hepatocytes from insulin-resistant Zucker fa ⁄ fa rats pptx
Tài liệu Báo cáo khoa học: "Japanese Dependency Parsing Using Co-occurrence Information and a Combination of Case Elements" pdf
... simply adding it as a feature does not improve the accuracy. 5.5.3 Changing the amount of training data Changing the size of the training data set, we investigated whether the degree of accuracy ... between bunsetsus. The weight of given features is learned from a training corpus by calculating the weights from the frequencies of the features in the trainin...
Ngày tải lên: 20/02/2014, 12:20
Báo cáo khoa học: Insulin like growth factor-1-induced phosphorylation and altered distribution of tuberous sclerosis complex (TSC)1⁄TSC2 in C2C12 myotubes pptx
... that the mammalian target of rapa- mycin (mTOR) plays a critical role in regulating the rate of protein synthesis and cell hypertrophy in skele- tal muscle [3–6]. mTOR is a serine ⁄ threonine kinase ... activity of the TSC1 ⁄ TSC2 complex and Rheb. Results and Discussion IGF-1-induced activation of mTOR signaling is prevented by PI3K inhibitor wortmannin a...
Ngày tải lên: 15/03/2014, 11:20
Báo cáo khoa học: Coiled–coil interactions modulate multimerization, mitochondrial binding and kinase activity of myotonic dystrophy protein kinase splice isoforms pptx
... 2006) doi:10.1111/j.1742-4658.2006.05138.x The myotonic dystrophy protein kinase polypeptide repertoire in mice and humans consists of six different splice isoforms that vary in the nature of their C-terminal tails and in the presence ... DMPK multimerization To investigate whether multimerization is involved in the formation of large complexes, and to identi...
Ngày tải lên: 16/03/2014, 13:20
Báo cáo khoa học: Ribonuclease H: molecular diversities, substrate binding domains, and catalytic mechanism of the prokaryotic enzymes ppt
... HI with the sub- strate and Mg 2+ , the RNA ⁄ DNA hybrid binds to the protein, such that the RNA backbone fits in one groove containing the active site and the DNA backbone fits in the other groove ... binding, but the former contributes to substrate binding more greatly than the latter [9]. TBP binds to the target DNA at the flat surface of the molec...
Ngày tải lên: 30/03/2014, 02:20
Tài liệu Báo cáo khoa học: A second independent resistance mechanism to Bacillus sphaericus binary toxin targets its a-glucosidase receptor in Culex quinquefasciatus docx
... binding site. These results therefore confirm the identity of the Bin toxin receptor as the Cqm1 a-glucosidase and map the Bin toxin binding site to the N-terminal region in the recombinant Rec-45. Expression ... 78% and 65%, respectively, to Cqm1. Investigation of the Bin toxin binding properties of a 45-kDa recombinant fragment of Cqm1 To further character...
Ngày tải lên: 19/02/2014, 07:20
Báo cáo khoa học: Thiaminylated adenine nucleotides Chemical synthesis, structural characterization and natural occurrence potx
... Because of the poor description of the methods used in the patent and the lack of any descrip- tion of the compound synthesized, it is difficult to draw a conclusion concerning the reasons for our failure ... The discovery of two natural thiamine adenine compounds further highlights the complexity and diversity of thiamine biochemistry, which is not restrict...
Ngày tải lên: 07/03/2014, 01:20
Báo cáo khoa học: Specific biomarkers for stochastic division patterns and starvation-induced quiescence under limited glucose levels in fission yeast docx
... con- ditions. They encode Ssp1 kinase (homolog of cal- cium–calmodulin-dependent protein kinase kinase) and Sds23 (an inhibitor of type 2A-related protein phos- phatases including Ppe1) [30]. Ssp1 and ... exhausted at the end of the experiment for the initial 4.4 mm glucose, and the dou- bling times from the cell number increase during the earlier period (4–8 h,...
Ngày tải lên: 14/03/2014, 23:20
Báo cáo khoa học: "Towards a Unified Approach to Memory- and Statistical-Based Machine Translation" pdf
... translations of higher probability by employing a set of simple operations, such as changing the translation of one or two words in the alignment under consideration, inserting into or deleting from the ... simple gloss. In 40% of the cases both seeds (the TMEM and the gloss) yield the same translation. Only in about 15-18% of the cases the translations ob...
Ngày tải lên: 17/03/2014, 07:20
Báo cáo khoa học: Increased expression of c-Fos by extracellular signal-regulated kinase activation under sustained oxidative stress elicits BimEL upregulation and hepatocyte apoptosis pot
... directly, leading to transactiva- tion of AP-1. On the basis of these findings, we next examined the expression and phosphorylation of c-Fos and c-Jun. The total amount of nuclear c-Fos increased ... an inhibitor of c-Jun N-terminal kinase, showed no effect on the DNA binding of c-Fos and c-Jun induced by treatment with ATZ + mercaptosuccinic acid, indicat- ing...
Ngày tải lên: 06/03/2014, 00:21
Báo cáo khoa học: Increased susceptibility of b-glucosidase from the hyperthermophile Pyrococcus furiosus to thermal inactivation at higher pressures pptx
... a-lactalbumin, apomyoglobin [12], tropomyosin [13] or synthetic proteins [14]. Hydrostatic pressure is increasingly being used in the study of protein folding, misfolding, aggregation and transitions. In ... b-glucosidase, the subunit interfaces involve fewer electrostatic interactions such as salt bridges and ion pairs than in the case of the enzymes from the hype...
Ngày tải lên: 07/03/2014, 03:20